Rare case of ameloblastoma with pulmonary metastases

Valkadinov, Ivan; Conev, Nikolay; Dzhenkov, Deyan; Donev, Ivan

doi:10.5582/irdr.2017.01032

Cited by 10 publications

(9 citation statements)

References 18 publications

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“…No standard treatment for MA exists, and most treatment decisions are based on case reports 6,7 . Curettage and radical resection are common treatments, radiotherapy and chemotherapy is recommended for inoperable metastatic lesions; however, its e cacy is unproven and it is considered a palliative treatment 8,9 . In our case, The patient is contraindication for operation due to poor physical condition and she could not tolerate systemic chemotherapy or radiotherapy due to extensive masses in both lungs.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Pulmonary Nodules after Surgery for Ameloblastoma: A Case of Misdiagnosis for 32 Years

Liu¹,

Yang²,

Yu³

et al. 2020

Preprint

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Background: We describe a rare case of metastatic ameloblastoma in a 68-year-old Chinese woman diagnosed with ameloblastoma of the right mandible in 1974. Case presentation: Despite radical resection, she experienced repeated local recurrences, including asymptomatic bilateral pulmonary nodules, cough, and hemoptysis diagnosed as non-malignant inflammatory cell infiltration. The patient developed an aggravated cough, palpitations, and dyspnea and was admitted to our respiratory department in September 2018. Chest computed tomography revealed multiple bilateral lung nodules, masses, and soft tissue opacities. She was diagnosed with advanced metastatic ameloblastoma in bilateral lungs via bronchoscopic biopsy, with a misdiagnosis time of 32 years. Because her systemic condition was poor, systemic chemotherapy and radiotherapy were not recommended. Dyspnea significantly improved after interventional bronchoscopic therapy and tumor electroexcision; she died of respiratory failure 1 year after diagnosis. Conclusions: Clinicians should carefully explore the medical histories of patients with surgical histories of ameloblastoma and subsequent unexplained pulmonary metastatic tumors to avoid misdiagnosis.

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Section: Discussionmentioning

confidence: 99%

Bilateral Pulmonary Nodules after Surgery for Ameloblastoma: A Case of Misdiagnosis for 32 Years

Liu¹,

Yang²,

Yu³

et al. 2020

Preprint

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“…On rare occasions the ameloblastoma can originate metastases even with a histologically benign appearance and is currently classified by WHO as metastatic or malignant ameloblastoma [2]. Most of metastases occur in the lungs and cervical lymph nodes but may also occur in the liver, spine, diaphragm, kidneys, brain, small intestine, spleen, scalp and myocardium [4]. The main metastatic dissemination theories are hematogenic, lymphatic and aspiration or implantation of cells at the time of surgery [5].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary metastasis of malignant ameloblastoma: case report and review

Nogueira

Catunda

Carneiro

et al. 2022

RGO, Rev. Gaúch. Odontol.

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Despite being a benign tumor of the maxillofacial region, some cases of ameloblastoma can be categorized as malignant ameloblastoma (or metastasizing) when metastases occur. The aim of this study is to report a rare case of lung metastasis from mandibular ameloblastoma, in order to review its risk and analyze the main anatomic sites that can occur with this disease. The case of a 48-year-old woman is described. She presented a metastatic pulmonary ameloblastoma 7 years after the removal of a mandibular ameloblastoma. During routine exams, a tumor in the left lung was observed. It was asymptomatic, near to the mediastinum, measured 7x5.5 cm. Transthoracic needle biopsy revealed ameloblastoma with the same histological characteristics of the primary tumor. After radiotherapy, the patient presented regression of the tumor. The patient has been under follow-up for 5 years and there is no presence of tumor. Ameloblastoma is an aggressive tumor not only in the region of origin, but also in distant regions, mainly in cases of recurrence. Metastases can cause high rates of morbidity, a fact that requires early treatment.

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“…Ameloblastomas are low-grade neoplasms of odontogenic epithelium that account for about 1% of all oral tumours and about 10% of odontogenic tumours [1]. They commonly occur in the mandible and involvement of the maxilla is reported to be about 20% [2,3]. Although they are considered to be benign tumours with a slow growth rate, they are locally aggressive with a high tendency for local recurrence if not removed completely [1,4].…”

Section: Introductionmentioning

confidence: 99%

“…Although they are considered to be benign tumours with a slow growth rate, they are locally aggressive with a high tendency for local recurrence if not removed completely [1,4]. Rarely, these tumours have the potential of distance metastasis [3], whereby this phenomenon is associated with a prolonged tumour duration and multiple recurrences following surgical interventions [2]. When histologically benign-appearing ameloblastoma does metastasize, it is referred to as metastatic ameloblastoma [5].…”

Section: Introductionmentioning

confidence: 99%

A rare case of maxillary ameloblastoma with lung metastasis: a case report

Sohal

Mlaga

Vuhahula

2020

Preprint

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Background Ameloblastomas are low-grade neoplasms of odontogenic epithelium that account for about 1% of all oral tumours and about 10% of odontogenic tumours. Rarely, these tumours have a potential of distance metastasis, and once they do metastasize, they are termed as metastatic ameloblastoma. Case presentation A 24-year-old African man presented with a massive swelling on the right side of the face for 2 years in 2018. He was previously operated for a swelling in the right side of the maxilla in 2012, which was histologically diagnosed as ameloblastoma. Clinical and radiological evaluation revealed a massive maxillary tumour that had a local extension to the brain. X-ray and CT scan of chest pointed out to metastatic mass in the lungs. Histology of the recurrent tumour mass revealed it to be follicular ameloblastoma and CT-guided fine-needle aspiration cytology of the lung mass showed microscopic features of ameloblastoma similar to primary jaw tumour. Conclusion A Close and long-term follow-up is mandatory in patients diagnosed with ameloblastoma even years after primary resection.

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Rare case of ameloblastoma with pulmonary metastases

Cited by 10 publications

References 18 publications

Bilateral Pulmonary Nodules after Surgery for Ameloblastoma: A Case of Misdiagnosis for 32 Years

Bilateral Pulmonary Nodules after Surgery for Ameloblastoma: A Case of Misdiagnosis for 32 Years

Pulmonary metastasis of malignant ameloblastoma: case report and review

A rare case of maxillary ameloblastoma with lung metastasis: a case report

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