Rare case of bilateral wrist and foot drop from SLE-related vasculitic polyneuropathy

Sodavarapu, Soujanya; Rudrangi, Rajani; Hoffman, Jeffrey

doi:10.1136/bcr-2019-232890

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Our patient's progress was very satisfactory under treatment with hydroxychloroquine combined with prednisone (which are first-line molecules and more accessible in our context), the literature describes good functional recovery under treatment [15,16].…”

Section: Discussionmentioning

confidence: 62%

Axonal Polyneuropathy as Initial Presentation of Lupus in a 15-year-old Male Teenager “Case Report”

Mbonda¹,

Nkoro²,

Gams³

et al. 2021

CNN

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Systemic lupus erythematosus (SLE) is a chronic autoimmune systemic disease, of the connectivitis group. This condition particularly affects young women between the ages of 20 and 40. Several systems are affected during the disease including the nervous system where central damage is more described than peripheral damage. We report here the case of a 15 year old male teenager with systemic lupus erythematosus whose initial clinical manifestation was acute inflammatory axonal polyneuropathy. This diagnosis was made on the basis of allodynia predominantly in gloves and socks with clinical examination of bilateral peripheral neurogenic syndrome predominant in both lower limbs all associated with fever. The electroneuromyogram showed signs of sensory and motor impairment (more marked in sensory) of the axonal type in both lower limbs, compatible with polyneuropathy. The patient developed several skin lesions such as erythematous and scaly patches on the extremities, and purpuric macules of the palms of hands. All the antibodies tested in the blood came back positive and the skin biopsy described a proliferation of vascular capillaries with a fibrous and myxoid wall, dissociated by inflammatory cells, suggesting inflammatory involvement. Under treatment with hydroxychloroquine and corticosteroids, the patient presented a marked improvement in the general condition as well as on the functional level with regression of sensory and motor disorders.

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Section: Discussionmentioning

confidence: 62%

Axonal Polyneuropathy as Initial Presentation of Lupus in a 15-year-old Male Teenager “Case Report”

Mbonda¹,

Nkoro²,

Gams³

et al. 2021

CNN

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“…For patients with fertility requirements, it has been reported that rituximab combined with adequate corticosteroid therapy can also achieve good results. 54 The present review of cases suggests that patients with SLE and CIDP respond well to corticosteroids and immunosuppressive therapy and that the early damage is reversible. The timely diagnosis and treatment of patients is therefore essential, and can significantly improve patient prognosis.…”

Section: Discussionmentioning

confidence: 80%

Progressive muscle weakness and amyotrophy during pregnancy as the first manifestation of systemic lupus erythematosus: A case report and review of literature

Wang

Ruan

et al. 2021

Science Progress

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Background: Systemic lupus erythematosus is a common autoimmune disease involving multiple systems. Clinical involvement of the central and peripheral nervous systems is not unusual, but peripheral neuropathy in systemic lupus erythematosus with chronic inflammatory demyelinating polyneuropathy is uncommon. Our study aimed to illustrate the clinical features, diagnosis, and treatment of systemic lupus erythematosus combined with chronic inflammatory demyelinating polyneuropathy, and to aid in the identification of peripheral neuropathy in systemic lupus erythematosus. Methods: This article reports a case of systemic lupus erythematosus with onset in pregnancy, with chronic inflammatory demyelinating polyneuropathy as the first manifestation. We then analyze the identification of common peripheral neuropathy in systemic lupus erythematosus in detail, based on a literature review of confirmed cases of systemic lupus erythematosus combined with chronic inflammatory demyelinating polyneuropathy. Results: A 34-year-old woman presented progressive muscle weakness and muscular atrophy in the extremities during pregnancy, 3 years previously. At 4 months after onset, she had completely lost the ability to hold objects and walk, and had slight numbness in the limbs, without paresthesia. Her condition was misdiagnosed as “motor neuron disease” at the time. Three years after onset, her condition was revisited because of nephrotic syndrome, and she was diagnosed with nephrotic syndrome and peripheral nerve injury caused by systemic lupus erythematosus. After immunosuppressive treatment with corticosteroids and intravenous cyclophosphamide, her symptoms of muscle weakness were markedly improved. This article summarizes the characteristics of systemic lupus erythematosus combined with chronic inflammatory demyelinating polyneuropathy that have been reported in the literature, from the aspects of morbidity, disease progression, nerve injury, laboratory examinations, and treatment response. Conclusions: Our identification of a common peripheral neuropathy in systemic lupus erythematosus will help to improve clinicians’ understanding of various peripheral neuropathies in systemic lupus erythematosus. It will also aid in the early diagnosis and treatment of such patients, thus improving their long-term prognosis.

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Rare case of bilateral wrist and foot drop from SLE-related vasculitic polyneuropathy

Cited by 2 publications

References 16 publications

Axonal Polyneuropathy as Initial Presentation of Lupus in a 15-year-old Male Teenager “Case Report”

Axonal Polyneuropathy as Initial Presentation of Lupus in a 15-year-old Male Teenager “Case Report”

Progressive muscle weakness and amyotrophy during pregnancy as the first manifestation of systemic lupus erythematosus: A case report and review of literature

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