Rare case of complete colon structure in a mature cystic teratoma of the ovary in menopausal woman: a case report

Ki, Eun Young; Jang, Dong Gyu; Jeong, Dong Jun; Kim, Chang‐Jin; Lee, Sung Jong

doi:10.1186/s12905-016-0349-8

Cited by 6 publications

(10 citation statements)

References 12 publications

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“…Teratoma frequencies found in our study were in concordance with data review [13][14][15][16]. The most affected group was women in reproductive age, but children and menopausal women were also concerned.…”

Section: Discussion Epidemiologysupporting

confidence: 91%

“…The prevalence rate of 20% of all ovarian neoplasms and the mean age of 31 years were in line with data of literature. Indeed, MCOT accounts for 10% to 20% of all ovarian adult neoplasms with approximately mean age of 27 years [4,14,15] and it represents 60% to 70% of all benign ovarian tumours [3,16].…”

Section: Discussion Epidemiologymentioning

confidence: 99%

“…The neural tissues (in 38% of cases) with its components are often: cerebellar cortex, ependymal, meninges or sympathetic ganglia. Endodermal tissues are in the majority of cases respiratory tissue (48%): bronchial epithelium; but, are also present in intestinal tissue (7-13%), salivary and thyroid tissues (3-14% of cases) [1,16,20]. Mesodermal tissues are: bone, cartilage, muscle, adipose tissue (67% to 75% of cases) and conjunctival tissue as adipose tissue [7].…”

Section: Discussion Epidemiologymentioning

confidence: 99%

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Mature Cystic Ovarian Teratoma: A Study of 43 Congolese Cases

Poaty¹,

Mboungou²,

Mavoungou³

et al. 2018

Hereditary Genet Curr Res

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Background: The mature cystic ovarian teratoma (MCOT) is a common benign ovarian neoplasm in the world, most prevalent among women of childbearing age. It is a disease related to parental imprinting in which genome is exclusively maternal. The purpose of the study was to review the tumour features in Congolese patients in order to clarify its prevalence, and its histological forms and to report the eventual associated chromosomal anomalies described in literature. Methods: It was a retrospective study of MCOT seen in University Teaching Hospital of Brazzaville for a period of seven years, and five DNAs previously extracted from five MCOT. Two antibodies: DLK1 and TIMP2 were also studied by immunohistochemistry (IHC). The confirmed positive diagnosis was performed by Hematoxylin-Eosin method. The eventual presence of chromosomal anomalies was investigated by metaphasic Comparative Genomic Hybridization (mCGH) method. IHC analysis had permit to verify expression of paternal imprinted gene DLK1 expression compared to maternal imprinted gene TIMP2. Results: During the study period, a total of 215 cases of ovarian neoplasms have been seen, from which 20% (43/215 cases) with confidence interval (CI) 95% = [14.7%-25.3%] were diagnosed MCOT. They represent 38.7% (43/111 cases) (IC 95% = [29.9%-48.1%]) of all benign ovarian tumors and they account for 0.4% (43/10170) of all tumors diagnosed during the study period. The average age of patients having MCOT was 30.7 years with extreme ranging from 2 to 70 years. Cutaneous tissue was the most prevalent histological form. About IHC analysis, no staining was observed with mono-allelic paternal gene DLK1 contrasting with high TIMP2 staining of nuclear stem cells in the basal layer of the epidermis. Concerning mCGH, no profile revealed chromosomal rearrangements. Conclusion: The benign ovarian teratoma remains a common ovarian neoplasm in young Congolese women in reproductive age. The predominant skin tissue form signed the current called ovarian dermoid cyst. The CGH analysis in our study revealed that pathology is not associated with chromosomal anomalies, but some associations are described in literature.

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Section: Discussion Epidemiologysupporting

confidence: 91%

Section: Discussion Epidemiologymentioning

confidence: 99%

Section: Discussion Epidemiologymentioning

confidence: 99%

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Mature Cystic Ovarian Teratoma: A Study of 43 Congolese Cases

Poaty¹,

Mboungou²,

Mavoungou³

et al. 2018

Hereditary Genet Curr Res

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“…This incidence is consistent with the occurrence of GI-type epithelium with or without other components in MCTs, which has been reported to be 7-13% (6,13). Totally organized GI tracts within ovarian MCTs are rare, with <20 previously reported cases (8)(9)(10)(11)(12). The present study revealed GI tract-like structures containing mucosa, MM, muscular walls and serosa in 3 (2.4%) of 126 MCT cases, and muscular walls without mucosa in 4 (3.2%) cases.…”

Section: Discussionmentioning

confidence: 75%

“…Thyroid tissues, salivary glands and ependymal tissues are occasionally present. Gastrointestinal (GI) epithelium and organized GI tracts may be observed in MCTs (5)(6)(7)(8)(9)(10)(11)(12). To date, only two previous articles (11,12) have described interstitial cells of Cajal (ICC) within the GI tract-like muscular walls in three sporadic cases of MCT.…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal tract-like muscular walls in ovarian mature cystic teratomas: A histopathological study

Matsukuma

Takahashi

Utsumi

et al. 2017

Molecular and Clinical Oncology

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Abstract. To elucidate the frequency and histopathological features of gastrointestinal (GI) tract-like muscular walls developing in ovarian mature cystic teratoma (MCT), the present study examined 149 MCTs surgically removed from 126 females, including 23 bilateral cases. GI tract-like muscular walls were identified in 9 (7.1%) cases, and were accompanied by mucosa in 5 cases, muscularis mucosae in 5 cases, serosa in 5 cases and all of these components in 3 cases. The mean size of the GI tract-like structures was 0.6 cm. The presence of MCT-related GI tract-like muscular walls was not significantly associated with patient age, size of MCTs or bilateral presence of MCT. The detected mucosae and muscular walls commonly demonstrated incomplete or anomalous features. Immunohistochemically, a few weakly KIT + spindle and/or stellate cells were identified in 7 cases (77.8% of the 9 cases of MCT-related GI tracts); these cells were presented chiefly near conspicuous or inconspicuous S-100 protein + neural tissues between the conspicuous or inconspicuous two muscular wall layers, indicating interstitial cells of Cajal (ICCs). Discovered on gastrointestinal stromal tumors 1 co-expression in KIT + ICCs was observed in only 1 case. Neural cell-related intramuscular cluster of differentiation 34 + cells were occasionally observed; however, no hyperplastic ICCs were observed in the present study.

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A case of mature cystic teratoma with intestinal structures harboring intestinal-type low-grade mucinous neoplasm

et al. 2018

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The formation of gastrointestinal-type epithelium is found in 7-13% of mature cystic teratomas, which are the most common germ cell tumors of the ovary. Few cases harboring organized gastrointestinal tract formation have been reported, and a mucinous neoplasm arising in them is further rare. Here, we report a case of an ovarian mature cystic teratoma with intestinal structures harboring intestinal-type mucinous neoplasm, mimicking low-grade appendiceal mucinous cystadenoma. A 66-year-old female, with remarkably increased serum carcinoembryonic antigen (CEA) level, underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy due to the ovarian tumor. The immunoprofile of the tumor showed CK7−/ CK20+. We review the past literatures, and then consider that the existence of mucinous neoplasm should be kept in mind if we find elevated level of serum CEA and the organized gastrointestinal development in an ovary. The immunoprofile of CK7/CK20 is useful to determine the origin of mucinous tumors associated with mature cystic teratomas.

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Rare case of complete colon structure in a mature cystic teratoma of the ovary in menopausal woman: a case report

Cited by 6 publications

References 12 publications

Mature Cystic Ovarian Teratoma: A Study of 43 Congolese Cases

Mature Cystic Ovarian Teratoma: A Study of 43 Congolese Cases

Gastrointestinal tract-like muscular walls in ovarian mature cystic teratomas: A histopathological study

A case of mature cystic teratoma with intestinal structures harboring intestinal-type low-grade mucinous neoplasm

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