Rare Case of Haemolytic Disease of the Newborn Caused by Anti-Kidd (b) and Review of the Literature. Seltener Fall von hämolytischer Erkrankung des Neugeborenen, verursacht durch Anti-Kidd (b) und Literaturübersicht

Abstract

We report on the very rare case of haemolytic disease of a newborn caused by diaplacental Anti-Kidd (b) from the mother. The second child of a 30 years old woman (two births, two pregnancies) developed a marked jaundice (maximal serum bilirubin 304.5 mol/l). Other reasons for thisjaundice could be excluded. Immunization was believed to stem from pregnancy, because the mother had never been transfused. In this context an overview is given on the literature concerning cases with haemolytic disease of the newborn due to Anti-Kidd (b) . From this and from our case we conclude that antibody screening of pregnant women should be performed either with test erythrocytes of two donors with at least 2 methods (indirect antiglobulin test with albumin and one stage enzyme test) or one method (indirect antiglobulin test with albumin technique) with test cells from 3 donors. In unclear cases of HDN matemal serum should be cross matched against patemal red cells.