Rare case of male breast intraductal papilloma progressing to invasive ductal carcinoma: A radiologic-pathologic correlation

Gaurav, Anand; Al-Khalisi, Nabil; Arif, Dauod; Hamidpour, Soheila; Lewis, Tiffany C.

doi:10.1016/j.radcr.2018.02.021

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…There are several conditions suggested as potentially responsible for the development of IPs in men, although nothing has been unequivocally proved. Gynaecomastia, misuse of anabolic steroids (through the consequent gynaecomastia or not) [10], increased serum prolactine levels [5], phenothiazine therapy (which is known to increase prolactine levels) and prolonged phenothiazine treatment [8] have all been reported as triggering factors for the development of IPs in the male breast. There is also a report of a case of an 11-year-old boy with in IP, after partial excision of a malignant brain tumour, following radiotherapy and chemotherapy [9].…”

Section: Discussionmentioning

confidence: 99%

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Intraductal papilloma of the male breast: a case report and review of the literature

Vagios

Nonni

Liakea

et al. 2019

Journal of Surgical Case Reports

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Intraductal papilloma is a benign neoplasm rarely found in the male breast. In this report, we present the case of a 55-year-old Caucasian man who presented with spontaneous bloody nipple discharge of the right breast. Ultrasonic and mammographic investigations revealed a sub-centimetre solid mass within a dilated duct. He underwent a total duct excision. Histopathologic examination confirmed a benign intraductal papilloma with no evidence of atypia or malignancy. A systematic review of the literature revealed six published cases of intraductal papillomas in men. Clinical presentation is the same as in women with single duct blood stained discharge being the most common presenting symptom. Surgical excision offers both histologic confirmation and definitive treatment. There is one case where the lump was not removed and progressed to malignancy years later. Male intraductal papillomas may be associated to medical treatments with hormonal activity given for other reasons or endocrine abnormalities.

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Section: Discussionmentioning

confidence: 99%

“…The excisional biopsy is also sufficient treatment for the IPs in men. In the case reported by Gaurav et al , an IP in a 52-year-old man was not initially removed and progressed to invasive ductal carcinoma years later [5].…”

Section: Discussionmentioning

confidence: 99%

Intraductal papilloma of the male breast: a case report and review of the literature

Vagios

Nonni

Liakea

et al. 2019

Journal of Surgical Case Reports

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“…These cases also highlight the relevance of treating bloody ND s with suspicion and treating all papillaroid clusters as intermediate grade. Possible transformation of benign duct papilloma to malignant during follow‐up in a male patient has also been reported to support this view …”

Section: Discussionmentioning

confidence: 99%

“…Possible transformation of benign duct papilloma to malignant during followup in a male patient has also been reported to support this view. 14…”

Section: Discussionmentioning

confidence: 99%

Cytological evaluation in males presenting with bloody nipple discharge, with or without breast mass: Report of two cases depicting two poles of the disease spectrum

Sood

2018

Diagnostic Cytopathology

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Nipple discharge (ND) either in the presence or in the absence of underlying mass is a very uncommon presentation in males and its bloody nature is still rarer. ND cytology in males has not been reported much in the literature. Spontaneous and expressed ND, however, can be very useful in establishing the diagnosis. Two males with bloody ND, one, without any palpable mass and another with underlying mass, were evaluated on ND cytology. The presence of loose papillaroid clusters and cell sheets with mild atypia was seen in ND smears itself in case 1. The discharge was more copious in case 2, but the ND smears were paucicellular. The presence of tall columnar cells in ND smears as well as in the FNA from underlying mass with clear features of malignancy was helpful in reaching the diagnosis of papillary carcinoma in case 2. Histopathology in case 1 was a spectrum of ADH to DCIS, whereas in case 2, was tubulopapillary carcinoma.Following two cases highlight the importance of the cytological evaluation of ND smears. K E Y W O R D S carcinoma, nipple discharge, papillaroid, papillary DCIS 1 | INTRODUCTION Males presenting with nipple discharge (ND) is very uncommon. There are very few reports describing ND, as a presenting feature, in cases of male breast cancer (MBC). 1,2 Other causes of ND can be duct papilloma, duct ectasia, fibrocystic change, gynaecomastia, and even skin adnexal tumors. 1 Evaluation of ND can be very helpful, especially when positive. 3,4 As there is limited data available on ND evaluation, in males, any new cases need to be recorded and added to the literature for a better understanding of this subject. 2 | CASE REPORTS 2.1 | Case 1 A 70-year-old male presented with unilateral bloody ND off and on. On examination, it was spontaneous and appeared to come from the central duct of left nipple. No mass lesion was found. The smears from the spontaneous ND showed papillaroid clusters of epithelial cells, without significant atypia, in a haemorrhagic background. Further squeesing yielded very cellular smears, comprising of monolayered sheets of epithelial cells and tiny papillaroid clusters with focal moderate atypia. Dyscohesive atypical epithelial cells were also present (Figure 1). It was reported as papillary lesion with atypical ductal hyperplasia and was advised radiological examination, and guided trucut biopsy. However, the surgeons performed a microdochotomy and the specimen showed four tiny foci of grey-white areas, ranging from 3 to 6 mm. No grossly dilated duct could be identified. Sections showed multiple foci of spectrum of ADH to DCIS (cribriform, solid, and papillary) and were ER, PR positive (Figure 2). No invasive carcinoma could be identified. Subsequently, the patient underwent mastectomy, which showed only benign rudimentary ducts embedded in adipose tissue and scant stroma without any significant proliferation. | Case 2A 62-year-old male presented with copious bloody ND off and on with painless enlargement of right breast. On examination, it was spontaneous and appeared to be multi...

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Papiloma intraquístico en la mama masculina

Alcalá

Jiménez

et al. 2022

Revista de Senología y Patología Mamaria

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Rare case of male breast intraductal papilloma progressing to invasive ductal carcinoma: A radiologic-pathologic correlation

Cited by 4 publications

References 13 publications

Intraductal papilloma of the male breast: a case report and review of the literature

Intraductal papilloma of the male breast: a case report and review of the literature

Cytological evaluation in males presenting with bloody nipple discharge, with or without breast mass: Report of two cases depicting two poles of the disease spectrum

Papiloma intraquístico en la mama masculina

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