Rare Case of Primary Adenoid Cystic Carcinoma of the Lung With Bilateral Kidney and Liver Metastasis

Abstract

Adenoid cystic carcinoma (ACC) is a rare epithelial tumor that is found in the salivary glands. It is typically slow-growing and follows an indolent course. While it can hematogenously spread to the lungs, distant metastases are rarely reported. Primary ACC in the lung is not common and makes up only 0.04-0.2% of all primary lung tumors. In addition, metastasis of the ACC to liver and bilateral kidneys is not common frequently documented. In this case report, we present a patient with unusual metastases of ACC, as well as non-specific symptoms that warrant discussion for ACC as potential differentials in the appropriate clinical setting.

Pulmonary Adenoid Cystic Carcinoma Mimicking Asthma-Like Symptoms: A Case Report and Literature Review

“…Unfortunately, the patient declined treatment and subsequently lost contact. Additionally, Nagi et al [ 16 ] reported a patient diagnosed with PACC, presenting primarily with dizziness. The patient’s treatment has progressed to an advanced stage, accompanied by distant metastasis and a sizable tumor.…”

“…In this section, we initially provide a comprehensive analysis of the clinical presentation, diagnosis, treatment, and prognosis of the present case. Subsequently, we selectively reviewed relevant case reports of first-time diagnosed PACC in the past 5 years [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. A comparative analysis is presented in Table 1 through a literature review.…”

“…This speculation underscores the importance of chest examinations alongside routine central nervous system assessments for patients primarily manifesting dizziness to prevent potential misdiagnoses. In cases of PACC with distant metastasis [7,16,18], palliative treatment is the sole option, contributing to a grim prognosis. One patient [18], subsequently developing severe pneumonia, succumbed to respiratory failure.…”