Rare Cases of Pediatric Vasoactive Intestinal Peptide Secreting Tumor With Literature Review: A Challenging Etiology of Chronic Diarrhea

Yeh, Pai-Jui; Chen, Shih-Hsiang; Lai, Jin-Yao; Lai, Ming‐Wei; Chiu, Cheng‐Hsun; Chao, Hsun‐Chin; Chen, Shih-Hsin; Wu, Ren‐Chin; Chen, Chien‐Chang

doi:10.3389/fped.2020.00430

Cited by 5 publications

(6 citation statements)

References 44 publications

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“…A literature review with a case series presentation published by Pai-Jui Yeh in 2020 [4] described data similar to our findings. Particularly, 38 articles containing 61 cases with VIP-secreting tumors were analyzed.…”

Section: Discussionsupporting

confidence: 89%

“…In children, the age of diagnosis is mainly between 2 and 4 years, the lowest reported instance being 2 weeks [20,21]. In terms of gender, in these studies, a predominance of females was found (1:2.46) [4].…”

Section: Discussionmentioning

confidence: 83%

“…However, the incidence of cases in children has not yet been established. Although the prevalence of the pediatric population is unknown, the estimated annual incidence is roughly 1 in 10 million [4,13].…”

Section: Discussionmentioning

confidence: 99%

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Chronic Diarrhea Caused by Vasoactive Intestinal Peptide-Secreting Tumor

Belei,

Basaca,

Heredea

et al. 2023

Life

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VIPomas are a type of neuroendocrine tumor that independently produces vasoactive intestinal peptide (VIP). VIPomas causing watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome are not frequently observed in adult patients without pancreatic ailments. However, in children, the occurrence of a VIPoma originating in the pancreas is exceedingly uncommon. Instead, WDHA syndrome is more commonly associated with neurogenic tumors that secrete VIP, often located in the retroperitoneum or mediastinum. Among infants, chronic diarrhea is a prevalent issue that often necessitates the attention of pediatric gastroenterologists. The underlying causes are diverse, and delays in arriving at a definitive diagnosis can give rise to complications affecting the overall well-being of the child. The authors present the case of an infant with chronic watery diarrhea, subocclusion manifestations, mild hypokalemia, and metabolic hyperchloremic acidosis secondary to a VIPoma in the retroperitoneum that was diagnosed via abdominal ultrasound and tomography. The laboratory results revealed lowered potassium levels and an excessive secretion of VIP. Following the surgical removal of the tumor, the diarrhea resolved, and both electrolyte levels and the imbalanced hormone levels returned to normal. Immunohistochemical examination confirmed the diagnosis of ganglioneuroblastoma, with N-MYC negative on molecular biology tests. We present the clinical and histo-genetic aspects of this rare clinical entity, with a literature review.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 83%

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Chronic Diarrhea Caused by Vasoactive Intestinal Peptide-Secreting Tumor

Belei,

Basaca,

Heredea

et al. 2023

Life

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“…Metastasis are mostly located in the liver, but rare case of lymph node, lung and kidney metastasis have been described[ 19 ].…”

Section: Pancreatic Malignant Tumors In Childrenmentioning

confidence: 99%

Could the burden of pancreatic cancer originate in childhood?

Diaconescu¹,

Gîlcă-Blanariu²,

Poamaneagra³

et al. 2021

WJG

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The presence of pancreatic cancer during childhood is extremely rare, and physicians may be tempted to overlook this diagnosis based on age criteria. However, there are primary malignant pancreatic tumors encountered in pediatric patients, such as pancreatoblastoma, and tumors considered benign in general but may present a malignant potential, such as the solid pseudo-papillary tumor, insulinoma, gastrinoma, and vasoactive intestinal peptide secreting tumor. Their early diagnosis and management are of paramount importance since the survival rates tend to differ for various types of these conditions. Many pediatric cancers may present pancreatic metastases, such as renal cell carcinoma, which may evolve with pancreatic metastatic disease even after two or more decades. Several childhood diseases may create a predisposition for the development of pancreatic cancer during adulthood; hence, there is a need for extensive screening strategies and complex programs to facilitate the transition from pediatric to adult healthcare. Nevertheless, genetic studies highlight the fact the specific gene mutations and family aggregations may be correlated with a special predisposition towards pancreatic cancer. This review aims to report the main pancreatic cancers diagnosed during childhood, the most important childhood diseases predisposing to the development of pancreatic malignancies, and the gene mutations associates with pancreatic malignant tumors.

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“…Otros autores como Yeh y colaboradores describen diarrea persistente y de difícil resolución en un 7-9 % pacientes con ganglioneuroblastoma secretor de péptido intestinal vasoactivo (32).…”

Section: Discussionunclassified

Factores quirúrgicos pronósticos del neuroblastoma en el Centro Regional Oriental de Oncología Pediátrica de Holguín, Cuba

Quintero Nicó,

Jiménez Reyes,

Zúñiga Fuentes

et al. 2023

Tesla rev. cient.

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Introducción: El neuroblastoma es la neoplasia sólida fuera de la cavidad craneal más frecuente en la edad pediátrica. Su particularidad se refleja en varias características clínicas y biológicas que se toman en cuenta para predecir los resultados terapéuticos. Objetivo: Identificar los factores quirúrgicos pronósticos en los pacientes diagnosticados con neuroblastoma en el Centro Regional Oriental de Oncología Pediátrica de Holguín, Cuba, durante la etapa comprendida de enero de 2010 a diciembre del 2022. Métodos: Se realizó un estudio descriptivo retrospectivo en 18 pacientes en los que se realizó la descripción de las variables: clínicas epidemiológicas, métodos de imágenes, diagnóstico patológico, tipo de cirugía y evolución. Resultados: El 50 % se diagnosticó antes del año de vida, con predominio en las niñas (66,65 %), en la localización abdominal y con afectación de la suprarrenal izquierda (87 %). La ultrasonografía, en asociación con la tomografía axial computarizada, permitió el diagnóstico inicial en un 94,50 %, y resultó de gran utilidad en la identificación de factores de riesgos quirúrgicos (78 %). El diagnóstico patológico evidenció predominio de los grados indiferenciados en el 66,70 % y en estadios más avanzados III y IV (55,60 %). Se realizó cirugía primaria (28 %) y secundaria (44 %), con un 28,0 % de fallecidos. Conclusiones: Esta enfermedad continúa siendo un desafío quirúrgico y, en ausencia de determinantes moleculares y citogenéticos, los factores clínicos e histopatológicos constituyen los de especial relevancia y correlación pronóstica. La transición estandarizada hacia la utilización de la clasificación pretratamiento de riesgo quirúrgico por imagenología es fundamental para la definición de la modalidad terapéutica a emplear.

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Rare Cases of Pediatric Vasoactive Intestinal Peptide Secreting Tumor With Literature Review: A Challenging Etiology of Chronic Diarrhea

Cited by 5 publications

References 44 publications

Chronic Diarrhea Caused by Vasoactive Intestinal Peptide-Secreting Tumor

Chronic Diarrhea Caused by Vasoactive Intestinal Peptide-Secreting Tumor

Could the burden of pancreatic cancer originate in childhood?

Factores quirúrgicos pronósticos del neuroblastoma en el Centro Regional Oriental de Oncología Pediátrica de Holguín, Cuba

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