Rare cause of fever in a patient with ulcerative colitis

Duque, Gabriela; Ferreira, Rosa; Figueiredo, Pedro; Sousa, Isabel; Ferreira, Manuela; Fernandes, Alexandra; Amaro, Pedro; Freire, Paulo; Portela, Francisco; Romãozinho, José Manuel; Sofia, Carlos

doi:10.1002/ibd.21721

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…We identified 50 cases of MAS associated with IBD including two unpublished cases from our clinic and one case from the IBD‐centre of Palermo (Table ),. The first report was published in 1988 followed by six isolated reports over the following 16 years, up to 2004.…”

Section: Resultsmentioning

confidence: 99%

“…Apparently, no patient resumed the same immunosuppressor given before MAS-onset. Four patients remained in remission on oral and topical mesalazine, 20,41,45,46 in two patients methotrexate was started successfully, one patient is on low-dose prednisolone (10 mg/day) and one is on low dose cyclosporine (target serum trough level 100 ng/mL, personal communication from ref 51) treatment.…”

Section: Clinical Presentation Of Mas In Ibdmentioning

confidence: 99%

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Systematic review: macrophage activation syndrome in inflammatory bowel disease

Fries

Cottone

Cascio

2013

Aliment Pharmacol Ther

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Section: Resultsmentioning

confidence: 99%

Section: Clinical Presentation Of Mas In Ibdmentioning

confidence: 99%

Systematic review: macrophage activation syndrome in inflammatory bowel disease

Fries

Cottone

Cascio

2013

Aliment Pharmacol Ther

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Hemophagocytic Lymphohistiocytosis and Inflammatory Bowel Disease: Case Report and Systematic Review

et al. 2020

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Aim: To report a case of a female patient with hemophagocytic lymphohistiocytosis (HLH) and to systematically review the available cases of the association between HLH and inflammatory bowel disease (IBD). Methods: In accordance to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, retrieval of studies was based on Medical Subject Headings and Health Sciences Descriptors, which were combined using Boolean operators. Searches were run on the electronic databases Scopus, Web of Science, MED-LINE (PubMed), Biblioteca Regional de Medicina, Latin American and Caribbean Health Sciences Literature, Cochrane Library for Systematic Reviews and Opengrey.eu. Languages were restricted to English, Spanish and Portuguese. There was no date of publication restrictions. The reference lists of the studies retrieved were searched manually. Results: The search strategy retrieved 223 references. In the final analysis, 28 references were included, with the report of 35 cases. The most common clinical finding was fever, 57% of patients had a cytomegalovirus infection and 30 patients were on thiopurines previously to HLH diagnosis. Most patients were treated with steroids and antiviral therapy. All-cause mortality was 22%. Conclusion: These findings suggest that there might be a connection of HLH to IBD, opportunistic viral infections and the use of thiopurines. Due to the severity of such disease, the clinical suspicion is paramount to early diagnosis and therapy.

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Rare cause of fever in a patient with ulcerative colitis

Cited by 2 publications

References 8 publications

Systematic review: macrophage activation syndrome in inflammatory bowel disease

Systematic review: macrophage activation syndrome in inflammatory bowel disease

Hemophagocytic Lymphohistiocytosis and Inflammatory Bowel Disease: Case Report and Systematic Review

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