Rare combination of exomphalos with umbilical cord teratoma

Keene, D. J. B.; Shawkat, Emma; Gillham, Joanna; Craigie, R. J.

doi:10.1002/uog.11124

Cited by 17 publications

(19 citation statements)

References 8 publications

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“…Pertinent literature regarding umbilical cord teratomas are presented and analyzed to demonstrate features of umbilical cord teratomas. (Table) reveals only 17 cases of umbilical cord teratoma [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] of which 3 contained immature tissue. 13,14,17 Analysis of the cases identified reveals a definite female predominance with 13 females (76.5%), 2 males (11.75%), and in 2 cases, the sex of the newborn was not provided (11.75%).…”

Section: Methodsmentioning

confidence: 99%

Umbilical Cord Teratomas Associated With Congenital Malformations

Adams

Bernieh

Morris

et al. 2019

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Congenital mature teratomas of the umbilical cord are extremely rare and pose a challenge in prenatal diagnosis. Mature teratomas are defined as tumors composed of mature tissues derived from more than 1 germ cell layer. The tumor often shows solid and cystic components, which adds to the difficulty of prenatal diagnosis. Although benign, mature teratomas of the umbilical cord are commonly associated with congenital malformations of the fetus with variable severity and rarely, with chromosomal abnormalities. Objective.— To review the clinical, radiologic, gross, and histologic features of umbilical cord teratoma; its differential diagnosis; and to emphasize the increased risk of associated congenital malformations. Data Sources.— Umbilical cord teratoma cases published in the literature. Conclusions.— Umbilical cord teratomas are difficult to diagnose by imaging studies alone and require histopathologic examination for diagnosis. Given the increased risk of associated anomalies and malformations, the finding of umbilical cord teratoma should trigger a detailed and comprehensive evaluation of the neonate for additional abnormalities.

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Section: Methodsmentioning

confidence: 99%

Umbilical Cord Teratomas Associated With Congenital Malformations

Adams

Bernieh

Morris

et al. 2019

Archives of Pathology &Amp; Laboratory Medicine

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“…Most of the cases (12/16) were in females, and most were recognized after term delivery. [ 1 2 3 5 6 ] Associated abnormalities were seen in 8/16 cases reported. Exomphalos was the most common abnormality (5/8 cases), followed by an umbilical hernia, exstrophy of the bladder and myelomeningocoel with hydrocephalous in others.…”

Section: Discussionmentioning

confidence: 99%

“…Immature elements as seen in our case have been described in three other cases. [ 1 2 7 ] Two of these cases were identified at 17 weeks of gestation and in these cases their occurrence could probably correspond to the developmental stage of the fetus. [ 6 ] Hartz and van der Sar reported the presence of immature elements in a term infant.…”

Section: Discussionmentioning

confidence: 99%

Immature teratoma at umbilicus region presenting as exomphalos: A case report with review of literature

Chavali

Bhaskar²,

Reddy

2014

Indian Journal of Medical and Paediatric Oncology

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Umbilical cord neoplasms are rare. Teratomas, which are accepted as the only true neoplasms at this site, are exceptional. These tumors are polymorphic in their presentation and are often associated with other abnormalities, with exomphalos being the most common abnormality. Histologically these tumors show mature tissues from all the three-germ layers. Immature elements as seen in our case are rare. Germ cells which have gone astray during embryonic development are thought to be the cells of origin of these tumors.

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“…ТП имеют тенденцию к быстрому росту, могут вызвать сердечную недостаточность и отек плода. Если в процесс вовлекаются пупочные сосуды или развивается омфалоцеле, возможен разрыв пуповины и кровотечение [14].…”

Section: Introductionunclassified

Umbilical Cord Teratoma: A Rare Case Report

Gansburgskii

Yal'tsev

Sleptsov

et al. 2021

Žurnal anatomii i gistopatologii

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The state of the stroma, blood vessels and the anatomical features of the umbilical cord are of direct diagnostic value, and various pathological changes can become the primary cause of fetal death. The frequency of umbilical cord tumors is not reliably known due to a very rare incidence: in the available literature there were reported about 19 cases.The aim of the study was to clinically and pathohistologically analyze a case of umbilical cord teratoma and to give an analytical review of recently reported cases.The material was obtained from a healthy 35-year-old woman with a third pregnancy. Combined ultrasound screening at the 20th week of pregnancy revealed a solid structure with cystic inclusions along the periphery on the umbilical cord. In the solid component, hyperechoic inclusions giving acoustic shadows were visualized; in the color Doppler imaging mode the neoplasm was avascular. A dead premature baby girl was born at 35th week. The cause of intrauterine fetal death was mechanical compression of the vessels of the umbilical cord by teratoma. Microscopic examination of the umbilical cord neoplasm in the area of the solid component demonstrated a pronounced development of the sebaceous glands, adipose tissue, myelinic nerve fibers, hair follicles; in the cystic component – epidermoid cysts. This evidenced about organismoid mature teratomas. Due to their rare incidence umbilical teratomas should be reported to better understand their pathomorphosis and impact on infant morbidity and mortality. Given the increased risk of concomitant malformations, the detection of an umbilical teratoma should be accompanied by a detailed and comprehensive examination of the newborn for additional pathologies.

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Rare combination of exomphalos with umbilical cord teratoma

Cited by 17 publications

References 8 publications

Umbilical Cord Teratomas Associated With Congenital Malformations

Umbilical Cord Teratomas Associated With Congenital Malformations

Immature teratoma at umbilicus region presenting as exomphalos: A case report with review of literature

Umbilical Cord Teratoma: A Rare Case Report

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