Rare G3P[3] rotavirus strain detected in Brazil: Possible human–canine interspecies transmission

Luchs, Adriana; Cilli, Audrey; Morillo, Simone Guadagnucci; Carmona, Rita de Cássia Compagnoli; Timenetsky, María do Carmo Sampaio Tavares

doi:10.1016/j.jcv.2012.01.025

Cited by 47 publications

(65 citation statements)

References 20 publications

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“…The widely documented zoonotic potential of RVA strains is best exemplified by globally emerging human RVs, such as G9 and G12, likely originating from porcine species by gene reassortment because similar G9 and G12 VP7 specificities are often observed in piglets [139,152,153,154]. Additionally, numerous reports have described interspecies transmission leading to sporadic cases of human disease with RVs from different animal species origin [72,155,156,157,158]. Table 1 summarizes common (G1–G4, P[6] and P[8]) and uncommon human RV G and P genotypes (suggestive of possible emergence via re-assortment) and G/P combinations (indicating possible direct transmission) that likely originated from swine.…”

Section: Zoonotic Potential Of Porcine Rv Strainsmentioning

confidence: 99%

Porcine Rotaviruses: Epidemiology, Immune Responses and Control Strategies

Vlasova

Amimo

Saif

2017

Viruses

188

197

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Rotaviruses (RVs) are a major cause of acute viral gastroenteritis in young animals and children worldwide. Immunocompetent adults of different species become resistant to clinical disease due to post-infection immunity, immune system maturation and gut physiological changes. Of the 9 RV genogroups (A–I), RV A, B, and C (RVA, RVB, and RVC, respectively) are associated with diarrhea in piglets. Although discovered decades ago, porcine genogroup E RVs (RVE) are uncommon and their pathogenesis is not studied well. The presence of porcine RV H (RVH), a newly defined distinct genogroup, was recently confirmed in diarrheic pigs in Japan, Brazil, and the US. The complex epidemiology, pathogenicity and high genetic diversity of porcine RVAs are widely recognized and well-studied. More recent data show a significant genetic diversity based on the VP7 gene analysis of RVB and C strains in pigs. In this review, we will summarize previous and recent research to provide insights on historic and current prevalence and genetic diversity of porcine RVs in different geographic regions and production systems. We will also provide a brief overview of immune responses to porcine RVs, available control strategies and zoonotic potential of different RV genotypes. An improved understanding of the above parameters may lead to the development of more optimal strategies to manage RV diarrheal disease in swine and humans.

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Section: Zoonotic Potential Of Porcine Rv Strainsmentioning

confidence: 99%

Porcine Rotaviruses: Epidemiology, Immune Responses and Control Strategies

Vlasova

Amimo

Saif

2017

Viruses

188

197

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“…Many examples of identical or almost identical transfer of animal segments of the virus to humans are now available (De Grazia et al, 2007;Simoes et al, 2008;Martella et al, 2011;Ghosh et al, 2012;Luchs et al, 2012;Midgley et al, 2012b). Most refer to segments isolated from cattle or pigs and have been detected mainly in developing countries, where humans and animals live closely, often sharing a domicile.…”

Section: Discussionmentioning

confidence: 99%

Rotavirus infections in domestic animals

Chatzopoulos

Athanasiou

Spyrou

et al. 2017

J Hellenic Vet Med Soc

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ABSTRACT. Rotaviruses are major enteric pathogens of humans and a wide variety of animals. Rotavirus infections have a worldwide prevalence. The viral genome is composed of 11 double-stranded RNA segments with six structural and five or six non-structural proteins. Over 35,000 strains have been identified and classified into five main (A, B, C, D, E) and three additional tentative (F, G, H) serotype groups. A binary classification system has been proposed defining 'G' or 'P' types, with at least 27 G and 35 P genotypes reported thusfar. The virus is transmitted primarily by the faecal-oral and oral routes. After attachment, entry into the host cells occurs through direct entry, fusion or endocytosis. Main mechanisms of Rotavirus-induced diarrhoea involve extensive enterocyte losses and nutrient disdigestion and malabsorption. Clinical features of Rotavirus infections range from asymptomatic infections to fulminant disease leading to rapid death. In calves, lambs and kids, piglets and foals, salient sign of the disease is diarrhoea; diarrhoeic faeces are white, yellow or, in severe cases, blood-tinted or frank haemorrhagic. In dogs and cats, the infection occurs usually as self-limiting diarrhoea. Avian Rotavirus infections are characterized by enteritis, growth depression and/or growth retardation. Definitive diagnosis of the infection can only be achieved by laboratory tests, including electron microscopic examination, immunohistochemical examination, immunofluorescence, ELISA, latex agglutination and molecular techniques. There is no specific treatment against Rotavirus infections. Treatment is based in providing supportive care and managing clinical signs and potential complications. Effective vaccines, containing inactivated, recombinant or attenuated strains of the virus, are available. Challenge studies have shown the ease of the virus in cross-infecting various animal species; animal strains of the virus may cross species and infect humans. Due to the ability of the virus to overcome species barriers, animal strains may act as natural source of viral genomes, promoting mutations and creating new viral genotypes, whose virulence cannot be predictable.

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“…To date, only rotaviruses of the G3P[3] genotype constellation have been described to infect dogs and to some extent also cats (Tsugawa & Hoshino, 2008), monkeys (Westerman et al, 2006), and bats (He et al, 2013). Although this particular genotype is rarely associated with human disease (De Grazia et al, 2007;Luchs et al, 2012), dogs are in focus for interspecies transmission of RVA as these viruses are able to infect a broad range of heterologous host species. So far, only little information is available about the different RVA genotypes able to infect dogs, but investigations have shown that rotavirus antigens were detectable in~7 % of faecal samples of young dogs with diarrhoea (Naumann, S. & Vahlenkamp, T. W., unpublished observations).…”

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confidence: 99%