Rare Isolated Cerebellar Metastases in Prostate Cancer: A Case Report with Review of Literature

Abstract

Prostate cancer is a common malignancy affecting elderly males. Generally, prostate cancer metastases to lymph nodes and skeletal lesions. Brain metastasis from prostate cancer is an uncommon phenomenon. When occurs, it affects the liver and lungs. Less than 1% of the cases show brain metastases, with isolated brain metastases being even more rare. We present the case of a 67-year-old male patient who was diagnosed to have prostate carcinoma and maintained on hormonal therapy. Later, the patient presented with raising serum-68 prostate-specific antigen (PSA) levels. Gallium-68 prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) scan revealed isolated cerebellar metastasis. He was later treated with whole brain radiotherapy.

Prostate-specific membrane antigen expression in intracranial lesions — a review of the primary, metastatic, and nonneoplastic lesions

“…Two cases report present multilocal brain PC metastases of a patient undergoing initial evaluation for newly diagnosed PC who had few brain lesions, apart from primary localization and lymph nodes and bone metastases [51], and one of asymptomatic PC recurrence in the form only of brain metastases [52]. There are two cases of cerebellar metastases with only mild neurological symptoms [53,54]. One patient with trigeminal neuralgia and no previous history of malignancy had been found to have PC metastases in the brain [55].…”