Rare isolation of Fusobacterium varium from a case of Fournier’s gangrene

Rachana, Krishna; Biswas, Rakhi; Bhat, Prasanna; Sistla, Sujatha; Kumari, Suneha; Kate, Vikram

doi:10.1016/j.anaerobe.2019.03.020

Cited by 8 publications

(2 citation statements)

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“…F . varium has gained attention for its potential association with ulcerative colitis; however, infection caused by this species has not been thoroughly investigated and has only been reported in case reports and small series [ 17 – 20 ]. To our knowledge, there has been no study describing the varied clinical characteristics of F .…”

Section: Discussionmentioning

confidence: 99%

Increasing Fusobacterium infections with Fusobacterium varium, an emerging pathogen

et al. 2022

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Infections caused by Fusobacterium species are rare; however serious infections with complications or mortality may occur occasionally. We conducted a retrospective study to investigate the clinical features of patients with Fusobacterium infections and the differences between infections caused by the species F. necrophorum, F. nucleatum, and F. varium. Additionally, we attempted to identify risk factors for Fusobacterium-associated mortality. This study included all patients at a large tertiary care teaching hospital in South Korea with Fusobacterium infections from January 2006 to April 2021. Demographic, clinical, laboratory, and outcome data were analyzed. Multiple logistic regression analysis was performed to assess the risk factors for in-hospital mortality associated with F. nucleatum and F. varium infections. We identified 272 patients with Fusobacterium infections during the study period. The number of Fusobacterium cases has increased recently, with F. varium infections markedly increasing since 2016 and causing a significant proportion of infections. Patients with F. varium infections were older and had a higher proportion of nosocomial infections than the other groups. The F. nucleatum and F. varium groups showed higher in-hospital mortality than the F. necrophorum group. Through logistic regression analysis, APACHE II score and serum albumin level were considered risk factors for in-hospital mortality. APACHE II score was positively correlated with age, red cell distribution width, and serum blood urea nitrogen, and negatively correlated with serum albumin level. Infections caused by Fusobacterium species are increasing. F. varium causes a significant proportion of severe infections.

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Section: Discussionmentioning

confidence: 99%

Increasing Fusobacterium infections with Fusobacterium varium, an emerging pathogen

et al. 2022

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“…The initial bacteriological studies are mainly related to the severe clinical cases with complicated forms of ARA, in which manifestations of anorectal sepsis are present. Another group of microbiological studies is related to Fournier's gangrene, which is most often a consequence of necrotic fasciitis due to diffuse necrotic phlegmonous inflammation in deep ARA (6,7,8,9). S. J. Eykyn et al (10), in 1986, studied 80 patients with anorectal sepsis over a three-year period.…”

Section: Structure Of Isolates In Adult Patientsmentioning

confidence: 99%

Analysis Of Data From The Aerobic Microbiological Landscape In Adult Patients Operated For Anorectal Abscesses

Hadzhieva,

Kalchev,

Chakarov

et al. 2023

SSM

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INTRODUCTION: Systematic analyses and studies on the microbiological spectrum of anorectal abscesses (ARAs) are currently lacking in modern proctology. Microorganisms from the colonic flora lead to retrograde infection of the anorectal glands with the subsequent appearance of ARA. AIM: The aim of this article is to analyze the frequency, type, and structure of the aerobic microbiological landscape in adult patients operated on for ARA. MATERIALS AND METHODS: A detailed analysis of the microbiological agents was performed in 254 operated adult patients, with a total of 274 isolates, which were divided as follows: 188 monocultures, 20 pairs of aerobic microbial associations, and 46 found sterile. Microbiological studies were performed by bacteriological examination of the purulent exudate taken during the operation. RESULTS: A total of 17 types of microbial cultures were identified. The most common were as follows: E. coli (n=160, 58.4%), Proteus spp. (n=15, 5.5%), Klebsiella spp. (n=11, 4%), Staphylococcus spp. (n=12, 4.4%), Enterococcus faecalis (n=8, 2.9%), Enterobacter cloacae complex (n=6, 2.2%). Monocultures were found in 188 patients (74.0%) and mixed infection with microbial associations in 20 patients (7.9%). Of the isolates, Gram (-) predominated, accounting for 201 (73.3%) strains, and Gram (+) constituted 26 (9.5%). CONCLUSION: So far, there have been only isolated reports on this issue in our country, without systematic studies. This determines the relevance and importance of our study on the aerobic microbiological landscape in operated adult patients with ARA. Routine microbiological screening should be an integral part of the diagnosis of ARA and of great help in the treatment.

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Bacteroides , Porphyromonas , Prevotella , Fusobacterium , and Other Anaerobic Gram‐Negative Rods

Conrads,

Nagy,

Könönen

2023

ClinMicroNow

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With increasing use of sequencing techniques, obligate anaerobic Gram‐negative rods are increasingly detected in clinical infections, such as brain or liver abscesses with Prevotella and Fusobacterium species predominating. Production of pigment is visible characteristic valuable in presumptive identification; the pigmented Gram‐negative anaerobic rods are composed of saccharolytic and asaccharolytic species of the genera Prevotella and Porphyromonas and pigment‐producing Alistipes species. Bacteroides species can be involved in part in polymicrobial necrotizing soft tissue infections, and the B. fragilis group is, after Gram‐positive anaerobic cocci, one of the most common anaerobes found in infected moderate to severe diabetic foot wounds. Antimicrobial resistance among Gram‐negative anaerobes continues to rise. The chapter gives characteristics of anaerobic Gram‐negative genera that have grown from clinical specimens.

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Rare isolation of Fusobacterium varium from a case of Fournier’s gangrene

Cited by 8 publications

References 8 publications

Increasing Fusobacterium infections with Fusobacterium varium, an emerging pathogen

Increasing Fusobacterium infections with Fusobacterium varium, an emerging pathogen

Analysis Of Data From The Aerobic Microbiological Landscape In Adult Patients Operated For Anorectal Abscesses

Bacteroides , Porphyromonas , Prevotella , Fusobacterium , and Other Anaerobic Gram‐Negative Rods

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