Rare metastasis of gastric cancer to the axillary lymph node: A case report

Abstract

Lymph node metastasis of gastric cancer is more common, metastatic lymph nodes are often around the stomach, and metastasis is carried out in a certain order, but gastric cancer metastasis to axillary lymph nodes is very rare. Due to the small number of patients with this kind of metastasis, its clinical features and treatment are not very clear. We initially thought that the enlarged axillary lymph nodes were inflammatory lesions. Axillary lymph node biopsy was later diagnosed as gastric cancer metastases to axillary lymph nodes. The patient refused further treatment and died 11 months after the second operation because of multiple systemic metastases. We believe that metastasis of gastric cancer to axillary lymph nodes is rare and the prognosis is poor. In clinical work, the possibility of metastatic lymph nodes should be considered in patients with a history of gastric cancer with enlarged axillary lymph nodes.

Unusual Metastasis of Signet-Ring Cell Gastric Cancer That Could Not Be Detected With 18F-FDG PET But With 68Ga-FAPI PET/CT

“…[8][9][10] Although regional lymph node metastasis is commonly expected in gastric cancers, subcutaneous and axillary metastases are uncommon and sparsely documented in the literature. 11,12 In the present case, bilateral axillary lymph node metastases were identified, resembling the pattern of spread seen in trunk malignant melanoma. 13 This case highlights the importance of considering lymphatic dissemination, particularly in cases of gastric cancers with cutaneous-subcutaneous involvement.…”

“…Recent studies have demonstrated that 68 Ga-FAPI PET/CT outperforms 18 F-FDG PET/CT in these specific subtypes, particularly in peritoneal carcinomatosis 8–10 . Although regional lymph node metastasis is commonly expected in gastric cancers, subcutaneous and axillary metastases are uncommon and sparsely documented in the literature 11,12 . In the present case, bilateral axillary lymph node metastases were identified, resembling the pattern of spread seen in trunk malignant melanoma 13 .…”

Case report: A case of rare metastasis of gastric cancer to the axillary lymph node metastasis treated with combination immunotherapy

“…Zhu reported a case of left axillary LN mass that grew faster after one month of radical total gastrectomy and then was considered as GC metastasis by axillary LN biopsy. This case refused further treatment and died 11 months after axillary LN metastasis (7). Kobayashi reported a case of isolated left axillary metastasis 21 months after radical distal gastrectomy and underwent radical axillary LN dissection without tumor recurrence in 1-year follow-up (8).…”

Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report

“…Other locoregional sites of origin include trunk or upper limb skin lesions, such as melanoma or other skin malignancies, including squamous or Merkel cell carcinomas [ 23 ]. Axillary LN mets from distant sites include those from gastrointestinal, lung, and ovarian primary tumors [ 5 , 6 ]. A few cases of endometrial and cervical cancer axillary LN mets have been reported [ 7 , 8 ].…”

“…Systemic mets to distant LNs, requiring tumor cell transport through the blood circulation, are rarely seen. Isolated reports of axillary LN metastases from gastric [ 5 ], lung [ 6 ], or endometrial cancers [ 7 , 8 ] do exist but the pathological and clinical variables responsible for this unusual pattern of spread are unknown. In a large database of the most common locations for mets for stage IV endometrial carcinoma, distant LN metastasis is not mentioned [ 9 ].…”