Rare occurrence of fatal<i>Candida haemulonii</i>peritonitis in a diabetic CAPD patient

Yuvaraj, Anand; Rohit, Anusha; Koshy, Priyanka; Nagarajan, P.; Nair, Sanjeev; Abraham, Georgi

doi:10.3109/0886022x.2014.944067

Cited by 10 publications

(3 citation statements)

References 5 publications

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“…vulnera form a fungal complex (named C. haemulonii complex) that is represented by emergent, opportunistic yeasts able to cause human infections with a wide range of clinical manifestations, varying from superficial to deep-seated infections, especially in individuals with immunocompromising health conditions [1]. In this sense, the main isolation sites of the C. haemulonii species complex described in the literature are blood, foot ulcers, nails, bones, skin wounds, and vagina; however, there are reports of isolates obtained from other body fluids such as cerebrospinal fluid, bronchoalveolar lavage, vaginal discharge, pleural effusion, peritoneal and ascitic fluids, bile, and urine [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Biofilm Formed by Candida haemulonii Species Complex: Structural Analysis and Extracellular Matrix Composition

Ramos

Mello

Branquinha

et al. 2020

JoF

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Candida haemulonii species complex (C. haemulonii, C. duobushaemulonii, and C. haemulonii var. vulnera) has emerged as opportunistic, multidrug-resistant yeasts able to cause fungemia. Previously, we showed that C. haemulonii complex formed biofilm on polystyrene. Biofilm is a well-known virulence attribute of Candida spp. directly associated with drug resistance. In the present study, the architecture and the main extracellular matrix (ECM) components forming the biofilm over polystyrene were investigated in clinical isolates of the C. haemulonii complex. We also evaluated the ability of these fungi to form biofilm on catheters used in medical arena. The results revealed that all fungi formed biofilms on polystyrene after 48 h at 37 °C. Microscopic analyses demonstrated a dense network of yeasts forming the biofilm structure, with water channels and ECM. Regarding ECM, proteins and carbohydrates were the main components, followed by nucleic acids and sterols. Mature biofilms were also detected on late bladder (siliconized latex), nasoenteric (polyurethane), and nasogastric (polyvinyl chloride) catheters, with the biomasses being significantly greater than on polystyrene. Collectively, our results demonstrated the ability of the C. haemulonii species complex to form biofilm on different types of inert surfaces, which is an incontestable virulence attribute associated with devices-related candidemia in hospitalized individuals.

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Section: Introductionmentioning

confidence: 99%

Biofilm Formed by Candida haemulonii Species Complex: Structural Analysis and Extracellular Matrix Composition

Ramos

Mello

Branquinha

et al. 2020

JoF

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“…7,57,64 Onychomycosis, peritonitis, leukocytosis, and high fever are features of systemic candidiasis caused by C. haemulonii sensu stricto and the infection is associated with peripheral vascular disease, lower extremity ulcers, and diabetes mellitus. 57,64,66 C. duobushaemulonii causes onychomycosis, and vulvovaginal candidiasis, and a characteristic of this species is that infects diabetic patients. 12,53,60,63,67 C. haemulonii var.…”

Section: Candidiasis Caused By C Auris and The C Haemulonii Complexmentioning

confidence: 99%

Candida haemulonii Complex and Candida auris: Biology, Virulence Factors, Immune Response, and Multidrug Resistance

Gómez-Gaviria¹,

Martínez-Álvarez²,

Chávez-Santiago³

et al. 2023

IDR

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There is worldwide concern about the constant increase in infections caused by Candida species that are multiresistant to antifungal drugs. The most common candidiasis is caused by Candida albicans, however, the species of the Candida haemulonii complex and Candida auris are emerging opportunistic pathogens, which isolation from clinical samples has significantly increased in the past years. The special interest in the study of these species lies in their ability to evade the action of antifungal drugs, such as amphotericin B, azoles, and echinocandins. In addition, the phenotypic changes of these species have given them the ability to easily adapt to environmental changes, including the host milieu and immunity. In this paper, a detailed review of the current literature on the C. haemulonii complex and C. auris is shown, analyzing aspects such as biology, immune response, putative virulence factors, infection, treatment, and the current strategies for diagnosis.

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“…8 Se encuentra un único reporte de caso publicado en el año 2014, en el cual un paciente diabético cursa con peritonitis por C. haemulonii, tratado con voriconazol y fallece al tercer día. 9 A continuación, se describe el caso de un paciente en diálisis peritoneal con peritonitis por este microorganismo.…”

Section: Introductionunclassified

Candida haemulonii: causa infrecuente de peritonitis asociada a diálisis peritoneal

Bravo

Larrarte

Quiñonez

et al. 2017

Infect

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Cómo citar este artículo: J. Bravo, et al. Candida haemulonii: causa infrecuente de peritonitis asociada a diálisis peritoneal. Infectio 2018; 22(1): 58-60 ResumenLa peritonitis fúngica es la responsable del 3 a 6% de los casos de peritonitis asociada a diálisis. Es causa importante de morbimortalidad y de falla de la técnica. El microorganismo aislado con mayor frecuencia es la Candida albicans. Sin embargo, en los últimos años la incidencia de nuevos casos asociados a Candida no albicans y otros hongos, ha aumentado. De estas especies patógenas, Candida haemulonii es causal de infecciones humanas, siendo inusual en pacientes en diá-lisis, encontrándose un caso reportado en la literatura de peritonitis asociado a diálisis. C. haemulonii supone ciertos retos diagnósticos ya que es un complejo de tres especies que requieren métodos moleculares de laboratorio para su diferenciación. Adicionalmente, tiene un perfil de multirresistencia a los antimicóticos que constituye para el clínico, un reto en el oportuno tratamiento de estos pacientes. A continuación, se describe un caso de peritonitis asociado a diálisis peritoneal por C. haemulonii. Palabras clave: Candida haemulonii, peritonitis, diálisis peritoneal, infección en diálisis Candida haemulonii, peritonitis, peritoneal dialysis, dialysis infectionsCandida haemulonii: an infrequent cause of dialysis related peritonitis. AbstractFungal peritonitis represents 3 to 6% of peritonitis in dialysis patients. It is an important cause of morbidity, mortality and technique failure. The most frequently isolated microorganism is Candida albicans; however, in recent years there are an increasing number of cases of non Candida albicans and other fungal peritonitis. Candida haemulonii causes human infections, but it is unusual in dialysis patients. There is one reported case of peritonitis in a dialysis patient. C. haemulonii generates certain diagnostic and therapeutic challenges because it is a complex of three species that can only be differentiated by specialized molecular methods and additionally, has a multidrug resistance profile. We describe the case of a dialysis patient with C. haemulonii peritonitis. REPORTE DE CASO IntroducciónLa peritonitis es una de las complicaciones más frecuentes en los pacientes en diálisis peritoneal, contribuyendo al 18% de mortalidad relacionada con infección.1 La peritonitis fún-gica es poco frecuente pero tiene complicaciones serias, con mortalidad del 15-50% y alto riesgo de falla de técnica por desarrollo de adherencias, esclerosis y falla de la membrana. 2Es responsable del 3 al 6% de las peritonitis y generalmente es causada por Candida albicans.3-4 También se han documentado casos por C. parapsilopsis, C. glabrata, C. tropicalis, C. krusei y de hongos filamentosos como Aspergillus spp y Penicillium spp, entre otros. 3En los últimos años se han identificado especies de Candida con menor susceptibilidad a los azoles. Entre estas se encuentra C. haemulonii, cuyo primer aislamiento clínico fue en 1984 en un paciente con falla renal 5 y ...

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Rare occurrence of fatalCandida haemuloniiperitonitis in a diabetic CAPD patient

Cited by 10 publications

References 5 publications

Biofilm Formed by Candida haemulonii Species Complex: Structural Analysis and Extracellular Matrix Composition

Biofilm Formed by Candida haemulonii Species Complex: Structural Analysis and Extracellular Matrix Composition

Candida haemulonii Complex and Candida auris: Biology, Virulence Factors, Immune Response, and Multidrug Resistance

Candida haemulonii: causa infrecuente de peritonitis asociada a diálisis peritoneal

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