Rare occurrence of intraosseous schwannoma in a young child, its review and its pathogenesis

Bansal, Ajay Kumar; Bindal, Ruchi; Shetty, Devi Charan; Dua, Mahima

doi:10.4103/0973-029x.92981

Cited by 9 publications

(16 citation statements)

References 18 publications

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“…In schwannoma, GFAP is a known marker for nerve sheath differentiation and has been established as a biomarker for certain nerve sheath tumors. [20][21][22] GAP43, S100B, FABP7, and the SOX10 transcription factors are all involved in neuronal development and were previously reported to be positively expressed in nerve-derived tumors such as schwannomas. [23][24][25][26][27] Our reidentification of such known biomarkers adds to our confidence in our study's novel differential expression results.…”

Section: Discussionmentioning

confidence: 99%

Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors

Sarver

Thayanithy

et al. 2015

Laboratory Investigation

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Human sarcomas comprise a heterogeneous group of more than 50 subtypes broadly classified into two groups: bone and soft tissue sarcomas. Such heterogeneity and their relative rarity have made them challenging targets for classification, biomarker identification, and development of improved treatment strategies. In this study, we used RNA sequencing to analyze 35 primary human tissue samples representing 13 different sarcoma subtypes, along with benign schwannoma, and normal bone and muscle tissues. For each sarcoma subtype, we detected unique messenger RNA (mRNA) expression signatures, which we further subjected to bioinformatic functional analysis, upstream regulatory analysis, and microRNA (miRNA) targeting analysis. We found that, for each sarcoma subtype, significantly upregulated genes and their deduced upstream regulators included not only previously implicated known players but also novel candidates not previously reported to be associated with sarcoma. For example, the schwannoma samples were characterized by high expression of not only the known associated proteins GFAP and GAP43 but also the novel player GJB6. Further, when we integrated our expression profiles with miRNA expression data from each sarcoma subtype, we were able to deduce potential key miRNA-gene regulator relationships for each. In the Ewing's sarcoma and fibromatosis samples, two sarcomas where miR-182-5p is significantly downregulated, multiple predicted targets were significantly upregulated, including HMCN1, NKX2-2, SCNN1G, and SOX2. In conclusion, despite the small number of samples per sarcoma subtype, we were able to identify key known players; concurrently, we discovered novel genes that may prove to be important in the molecular classification of sarcomas and in the development of novel treatments.

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Section: Discussionmentioning

confidence: 99%

Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors

Sarver

Thayanithy

et al. 2015

Laboratory Investigation

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“…The relative percentages of Antoni A and B zones vary greatly from case to case. Kumar et al, pointed out that a variety of secondary changes could commonly be seen, because of their long standing durations, before they were treated [7]. These could be thick walled, hyalinized blood vessels and extensive cystic changes, which resembled thrombosed blood vessels, with only a thin peripheral rim of neoplastic cells.…”

Section: Resultsmentioning

confidence: 99%

Intra-Oral Schwannoma- A Case Report

Parhar

Singh

Nayyar

et al. 2014

JCDR

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“…Schwannoma also referred to as neurilmoma, neurinoma, and perineural fibroblastoma is a solitary soft tissue or intra-bone lesion, most often developped from a Peripheral nerve [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Solitary intraosseous schwannoma of the base and vault of the skull: a summary review of such unusual location

et al. 2015

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Intra-osseous schwannoma is a rare mesenchymal tumor. Although, the head and neck region is one of the most common sites for schwannomas, its location at the skull bone is uncommon and accounted for less than 0.2% in the largest series of bone tumors ever reported. Furthermore, it is most often a benign tumor, malignant transformation is exceedingly rare.Clinical presentation is non-specific, most often symptoms are associated with compression and invasion of adjacent organs. Neuro-imaging features are non-specific and the diagnosis is based on histological examination with immunohistochemical study.Surgery remains the aim of treatment. However, radiation therapy could be an interesting therapeutic option in unresectable tumors.This systemic review offers new clinicopathological data useful for better defining the diagnosis and clinicopathological behavior of schwannoma. The purpose of this work is to raise awareness among clinicians adding this clinical entity as a differential diagnosis when a mass of skull bone is identified.

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Rare occurrence of intraosseous schwannoma in a young child, its review and its pathogenesis

Cited by 9 publications

References 18 publications

Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors

Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors

Intra-Oral Schwannoma- A Case Report

Solitary intraosseous schwannoma of the base and vault of the skull: a summary review of such unusual location

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