Rare occurrence of metastasis from lung cancer to the anus: case report and review of the literature

Al‐Tarakji, Mohannad; Feilchenfeldt, Jonas; Haidar, Abdulrazzaq; Szabados, Lajos; Abdelaziem, Sherif; Ali, Syed Muhammad; Toro, Adriana; Carlo, Isidoro Di

doi:10.1186/s12957-016-0909-2

Cited by 17 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Owing to several limitations associated with early stage diagnosis, majority of lung cancer patients diagnosed at the median or advanced stage. Additionally, due to the moderate progress provided by chemotherapeutics and the development of drug resistance 1,2 , the use of natural products for lung cancer treatment has attracted the attention 5 . In this study, chemical examination of Phoma sp .…”

Section: Discussionmentioning

confidence: 99%

“…The major lung cancer NSCLC includes various types such as squamous cell carcinoma, large cell carcinoma, adenocarcinoma, pleomorphic, carcinoid tumor, and salivary gland carcinoma 1 . The metastasis-related death found to be as high as 90% of all lung cancer mortality 2 . Despite advances in conventional treatment procedures such as surgery, radiation, chemotherapy and targeted therapy, however, the clinical outcomes of the current therapies are still not at satisfactory level.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells

et al. 2018

Sci Rep

View full text Add to dashboard Cite

As part of our ongoing search for novel therapeutic structures from microorganism, the chemical examination of marine fungus Phoma sp. resulted in the isolation of ergosterol, ergosterol peroxide (EP), and 9,11-dehydroergosterol peroxide (DEP). The bioassay results demonstrated that the three isolates reduced the viability of various cancer cells, with EP being highest in human lung cancer cell line A549 cells. EP induced caspase-dependent apoptosis through mitochondrial damage in A549 cells. Additionally, EP-induced ROS generation and apoptosis were attenuated by ROS-generating enzymes inhibitors and antioxidant N-acetylcysteine, indicated that ROS played an important role in EP-mediated apoptosis in A549 cells. Furthermore, it was observed that EP induced ROS-dependent autophagy, which attenuated apoptosis in A549 cells. On the other hand, EP reduced the LPS/ATP-induced proliferation and migration of A549 cells through attenuated NLRP3 inflammasome activity. Additionally, EP showed synergistic cytotoxic effect with antitumor drug Sorafenib in A549 cell viability inhibition. Furthermore, Micro-Western Array and Western blot analyses demonstrated that the protein levels of EGFR, HSP27, MEK5, AKT1, mTOR, Smad2, Smad3, TAB1, NF-κB, and HIF1-α decreased, while the levels of p-p38α, p-ERK1/2, p-JNK, fibronectin and p27 increased. Collectively, the results of this study demonstrated that EP might be useful to develop a therapeutic candidate for lung cancer complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…[8,9] Metastatic lung cancer has been known to be highly malignant, and has been noted to have spread to any location, from the oral cavity to the anus. [10] Liu et al [11] reported that in the 64 documented cases, 57 patients displayed metastasis. The jejunum was the most common site, as noted in 50.9% (29/57) of patients, followed by the ileum, in 33.3% (19/57), and the duodenum, in 15.8% (9/57).…”

Section: Discussionmentioning

confidence: 99%

Perforation of small intestine secondary to metastatic lung adenocarcinoma

et al. 2018

View full text Add to dashboard Cite

Rationale:About 50% of patients with a diagnosis of nonsmall cell lung carcinoma exhibit metastatic disease at the time of diagnosis. The preferential sites of extrapulmonary spread are the lymph nodes, liver, brain, adrenal glands, and bones; gastrointestinal tract perforation secondary to metastatic lung cancer is extremely rare.Patient concerns:A 60-year-old male nonsmoker patient presented with a 20-day history of facial, neck, and right upper limb edema. Physical examination revealed a 3.5 cm mass in his right chest. Computed tomography (CT) revealed a 4 cm mass near the right lung hilum.Diagnosis:Biopsy of the right chest wall mass revealed low differentiated lung adenocarcinoma. Additionally, retroperitoneal lymphadenopathy, pericardial effusion, metastases in the mediastinum, bilateral adrenal gland, and right thoracic wall nodule, as well as multiple bone metastases were also found.Interventions:Since the patient was diagnosed with multiple metastatic lung cancer, chemotherapy was started. One week after chemotherapy, he experienced a sudden acute abdominal pain. Abdominal CT examination indicated the possibility of intestinal perforation. Hence, the patient underwent an emergency operation. During the surgical procedure, 2 perforations of size 1×1 cm2 were discovered at 110 cm and 140 cm of the jejunum from Treitz's ligament. Then, an intestinal resection and end-to-end anastomosis were performed. The pathological diagnosis of the resected specimen revealed that it was a metastatic lung adenocarcinoma of small intestine.Outcomes:The patient died 10 days after operation and 19 days following the cancer diagnosis due to septic shock.Lessons:Gastrointestinal tract metastasis from the lung is uncommon, but the survival rate is extremely low; therefore, it should be considered as a possibility in patients who present with any of the gastrointestinal symptoms.

show abstract

“…In a large retrospective study done by Kim et al[ 5 ] gastrointestinal metastasis was found in 0.19% of all the cases with small bowel being the most common site, although autopsy studies revealed higher rates of metastatic disease[ 1 ]. Metastatic lung cancer has known to spread to any location from the oral cavity to the anus[ 6 ] with lymphatic and hematogenous routes being the possible modes of spread[ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Lung cancer metastasis to the gastrointestinal system: An enigmatic occurrence

Badipatla

Yadavalli

Vakde

et al. 2017

WJGO

View full text Add to dashboard Cite

Adenocarcinoma of the lung infrequently metastasizes to the gastrointestinal tract. We report a rare case of a 65-year-old male with no respiratory symptoms diagnosed with adenocarcinoma of the lung by histopathological examination of metastatic sites which included an ulcer in the gastric body and a mass in the rectum. Metastatic disease also involved the liver as well. Patient was treated with systemic chemotherapy but unfortunately expired five months after the diagnosis was made.

show abstract

Rare occurrence of metastasis from lung cancer to the anus: case report and review of the literature

Cited by 17 publications

References 15 publications

Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells

Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells

Perforation of small intestine secondary to metastatic lung adenocarcinoma

Lung cancer metastasis to the gastrointestinal system: An enigmatic occurrence

Contact Info

Product

Resources

About