Rare Oncogenic Fusions in Pediatric Central Nervous System Tumors: A Case Series and Literature Review
Melek Ahmed,
Anne Sieben,
Toon Van Genechten
et al.
Abstract:Background and Objectives: Central Nervous System (CNS) pediatric tumors represent the most common solid tumors in children with a wide variability in terms of survival and therapeutic response. By contrast to their adult counterpart, the mutational landscape of pediatric CNS tumors is characterized by oncogenic fusions rather than multiple mutated genes. CNS pediatric tumors associated with oncogenic fusions represent a complex landscape of tumors with wide radiological, morphological and clinical heterogenei… Show more
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