Rare pancreatic metastasis of undifferentiated pleomorphic sarcoma originating from the pelvis: A case report

Ohsawa, Manato; Mikuriya, Yoshihiro; Ohta, Kouji; Tanada, Minoru; Yamamoto, Noriaki; Teramoto, Norihiro; Kiyono, Masahiro; Sugihara, Shinsuke

doi:10.1016/j.ijscr.2020.02.041

Cited by 4 publications

(8 citation statements)

References 19 publications

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“…Some studies suggested that chemotherapy and radiotherapy did not significantly prolong UPS patient survival, and some researchers even believed that their side effects may be harmful to the prognosis of patients. [32][33][34] Radiotherapy and chemotherapy had no prognostic value in the present study, which may be related to radiotherapy and chemotherapy commonly being used in high-risk UPS patients. The year of diagnosis may influence the results due to the new therapeutic developments for STS, such as immunotherapy and targeted therapy.…”

Section: Discussioncontrasting

confidence: 59%

Nomogram for predicting cancer-specific survival in undifferentiated pleomorphic sarcoma: A Surveillance, Epidemiology, and End Results -based study

Zhao

Xue

et al. 2021

Cancer Control

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Introduction The purpose of this study was to construct and validate a nomogram for predicting cancer-specific survival (CSS) in undifferentiated pleomorphic sarcoma (UPS) patients at 3, 5, and 8 years after the diagnosis. Methods Data for UPS patients were extracted from the SEER (Surveillance, Epidemiology, and End Results) database. The patients were randomly divided into a training cohort (70%) and a validation cohort (30%). The backward stepwise Cox regression model was used to select independent prognostic factors. All of the factors were integrated into the nomogram to predict the CSS rates in UPS patients at 3, 5, and 8 years after the diagnosis. The nomogram’ s performance was then validated using multiple indicators, including the area under the time-dependent receiver operating characteristic curve (AUC), consistency index (C-index), calibration curve, decision-curve analysis (DCA), integrated discrimination improvement (IDI), and net reclassification improvement (NRI). Results This study included 2,009 UPS patients. Ten prognostic factors were identified after analysis of the Cox regression model in the training cohort, which were year of diagnosis, age, race, primary site, histological grade, T, N, M stage, surgery status, and insurance status. The nomogram was then constructed and validated internally and externally. The relatively high C-indexes and AUC values indicated that the nomogram has good discrimination ability. The calibration curves revealed that the nomogram was well calibrated. NRI and IDI values were both improved, indicating that our nomogram was superior to the AJCC (American Joint Committee on Cancer) system. DCA curves demonstrated that the nomogram was clinically useful. Conclusions The first nomogram for predicting the prognosis of UPS patients has been constructed and validated. Its usability and performance showed that the nomogram can be applied to clinical practice. However, further external validation is still needed.

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Section: Discussioncontrasting

confidence: 59%

Nomogram for predicting cancer-specific survival in undifferentiated pleomorphic sarcoma: A Surveillance, Epidemiology, and End Results -based study

Zhao

Xue

et al. 2021

Cancer Control

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“…La mayoría de lo publicado a este respecto son series de casos y casos clínicos aislados, habiendo solo encontrado en la literatura tres casos de metástasis pancreáticas únicas de SPI 1,3,5 tras la reclasificación de la World Health Organization en 2002 6 . La cirugía de resección radical es el único tratamiento potencialmente curativo y que conlleva un aumento del periodo libre de enfermedad 1,2 , no existiendo consenso en cuanto al beneficio de la quimioterapia o radioterapia complementaria para este tipo de tumores 1 .…”

Section: Discussionunclassified

Metástasis pancreática de sarcoma pleomórfico indiferenciado. Una entidad extremadamente rara

Alonso-Batanero¹,

Solar-García²,

Burgo

et al. 2024

CIRU

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El sarcoma pleomórfico indiferenciado (SPI) es un tumor maligno muy agresivo que se origina en el hueso o tejidos blandos, siendo su localización más frecuente en las extremidades. Presentamos el caso de un varón de 71 años que a los dos años de seguimiento tras cirugía de exéresis de un SPI presenta una metástasis única de origen sarcomatoide a nivel del páncreas que se trató mediante duodenopancreatectomía cefálica. Las metástasis sarcomatoides a nivel de páncreas son extremadamente raras.

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“…In der Literatur wurden verschiedene Lokalisationen des UPS wie z. B. pulmonal [14], im Pankreas [9], am Herzen [15] und in der Harnblase [8]…”

Section: Soft Tissue Neoplasms • Radiation • Radiotherapy Adjuvant •unclassified

“…In der Literatur wurden verschiedene Lokalisationen des UPS wie z. B. pulmonal [ 14 ], im Pankreas [ 9 ], am Herzen [ 15 ] und in der Harnblase [ 8 ] beschrieben. Eine solitäre lokoregionäre Metastase des UPS im M. quadratus femoris, wie in dem vorgestellten Fall, stellt eine Besonderheit dar und wird zum ersten Mal beschrieben.…”

Section: Diskussionunclassified

Solitäre lokoregionäre Metastase eines undifferenzierten pleomorphen Sarkoms im M. quadratus femoris

et al. 2021

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ZusammenfassungDas undifferenzierte pleomorphe Sarkom („undifferentiated pleomorphic sarcoma“ [UPS]) gehört zur Gruppe der Weichteilsarkome und macht fast 10 % aller Weichteilsarkome aus. Der Fall eines 49-jährigen Patienten wird vorgestellt, bei dem die kompartmentorientierte Resektion eines primären UPS im linken Musculus gluteus maximus mit adjuvanter Radiotherapie (60 Gy) durchgeführt wurde. Im Rahmen der Tumornachsorge (3 Jahre später) wurde eine lokoregionäre Metastase an einer ungewöhnlichen Lokalisation im M. quadratus femoris festgestellt, welche mittels einer In-toto-Resektion mit intraoperativer Radiotherapie (10 Gy) behandelt wurde. Der intra- und postoperative Verlauf gestalten sich komplikationslos ohne neurologische Defizite. Im Rahmen der Nachtuntersuchung 6 Monate postoperativ war der Patient tumor- und beschwerdefrei.

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Rare pancreatic metastasis of undifferentiated pleomorphic sarcoma originating from the pelvis: A case report

Cited by 4 publications

References 19 publications

Nomogram for predicting cancer-specific survival in undifferentiated pleomorphic sarcoma: A Surveillance, Epidemiology, and End Results -based study

Nomogram for predicting cancer-specific survival in undifferentiated pleomorphic sarcoma: A Surveillance, Epidemiology, and End Results -based study

Metástasis pancreática de sarcoma pleomórfico indiferenciado. Una entidad extremadamente rara

Solitäre lokoregionäre Metastase eines undifferenzierten pleomorphen Sarkoms im M. quadratus femoris

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