Rare presentation of<i>Candida albicans</i>: infective endocarditis and a pulmonary coin lesion

Öner, Taliha; Korun, Oktay; Çelebi, Ahmet

doi:10.1017/s1047951117002645

Cited by 2 publications

(4 citation statements)

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“…It is imperative to distinguish the difference between commensal and invasive virulent growth; invasion is distinct from superficial colonization as the former is accompanied by inflammatory signals, resulting from the activated immune response. Clinical cases presenting C. albicans infections of the urogenital tract [1][2][3][4][5][6][7][8], kidney [1,7,[9][10][11][12][13], liver [14,15], lungs [16][17][18], spleen [19,20] and even the heart [21][22][23][24][25][26] have been reported. In rare cases, mostly in neonates, C. albicans can traverse the blood-brain barrier, resulting in infections of the brain [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host

Silao

Ljungdahl

2021

Pathogens

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Nutrient uptake is essential for cellular life and the capacity to perceive extracellular nutrients is critical for coordinating their uptake and metabolism. Commensal fungal pathogens, e.g., Candida albicans, have evolved in close association with human hosts and are well-adapted to using diverse nutrients found in discrete host niches. Human cells that cannot synthesize all amino acids require the uptake of the “essential amino acids” to remain viable. Consistently, high levels of amino acids circulate in the blood. Host proteins are rich sources of amino acids but their use depends on proteases to cleave them into smaller peptides and free amino acids. C. albicans responds to extracellular amino acids by pleiotropically enhancing their uptake and derive energy from their catabolism to power opportunistic virulent growth. Studies using Saccharomyces cerevisiae have established paradigms to understand metabolic processes in C. albicans; however, fundamental differences exist. The advent of CRISPR/Cas9-based methods facilitate genetic analysis in C. albicans, and state-of-the-art molecular biological techniques are being applied to directly examine growth requirements in vivo and in situ in infected hosts. The combination of divergent approaches can illuminate the biological roles of individual cellular components. Here we discuss recent findings regarding nutrient sensing with a focus on amino acid uptake and metabolism, processes that underlie the virulence of C. albicans.

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Section: Introductionmentioning

confidence: 99%

Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host

Silao

Ljungdahl

2021

Pathogens

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“…The most commonly isolated fungus in many fungal endocarditis is Candida albicans; followed by Aspergillus spp. 1,2,6,7 From infective endocarditis, the rate of fungal endocarditis in varies between 0% and 12%. 8,9 In our hospital, between January 2008 and December 2017, 211 episodes of 172 non-neutropenic patients with candidemia were evaluated, with only two cases (0.9%) of endocarditis due to Candida albicans being detected.…”

Section: Discussionmentioning

confidence: 99%

“…In the development of fungal endocarditis, risk factors such as underlying heart valve disease, drug abuse, immunosuppression, long-term use of intravenous catheters, total parenteral nutrition, and prolonged exposure to broad spectrum antibiotics have been shown in several studies for the development of candidiasis. 7,[10][11][12] If the patient has a catheter as a risk factor, it is recommended to remove the catheter as early as possible in conjuction with appropriate antifungal therapy. [13][14][15] Both of our patients had a ventriculoperitoneal shunt associated infection; indwelling intravenous catheter and prolonged antibiotic use as risk factors.…”

Section: Discussionmentioning

confidence: 99%

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Native valve endocarditis due to Candida albicans in two children: Two new case reports

et al. 2019

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Candida endocarditis (CE) is a rare and serious complication of candidemia. Using current diagnostic tools a confirmed diagnosis is often delayed and outcomes remain poor. The majority of new cases occur following cardiac valvular surgery, and/or in patients with the following risk factors: intravenous drug use, cancer chemotherapy, prolonged presence of central venous catheters, and prior history of bacterial endocarditis. It is not a common complication in non‐neutropenic patients particularly with the absence of a prosthetic valve, and very few reports in the literature are available. Attempting to add to the limited data, 211 candidemia episodes from 172 nonneutropenic pediatric cases between January 2008 and December 2017 were evaluated. All patients were considered asymptomatic for underlying heart disease. However, 2 (0.9%) patients with a central venous catheter were determined as having endocarditis following echocardiography.

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Rare presentation ofCandida albicans: infective endocarditis and a pulmonary coin lesion

Abstract: We present a case of a rare association of infective endocarditis and a coin lesion in the lung caused by Candida albicans. The lesion disappeared after 6 weeks of treatment with 5 mg/kg/day amphotericin B.

Cited by 2 publications

References 12 publications

Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host

Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host

Native valve endocarditis due to Candida albicans in two children: Two new case reports

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