Rare presentation of metastatic renal cell carcinoma to thyroid gland: A case report

Habibullah, Ammar; Abdelmonim, Sherif K.; Aldajani, Ahmad; Rajab, Mohannad; Alessa, Mohammad A; Alkaf, Haddad H

doi:10.1016/j.amsu.2020.06.021

Cited by 3 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to surgical treatment, sunitinib is also an effective drug for the treatment of metastatic RCC [ 27 ]. However, because RCC itself has a certain resistance to radiotherapy, postoperative radiotherapy is not recommended [ 30 ]. As RCC patients still have severely delayed metastasis after nephrectomy, RCC patients should always be on guard against the occurrence of RCC thyroid metastasis, even a few years after nephrectomy [ 31 ].…”

Section: The Primary Tumormentioning

confidence: 99%

“…If the patient has a history of other malignant tumors and is suspected to have secondary thyroid neoplasms, FNAB may obtain a correct diagnosis [ 4 ], and useless thyroidectomy can be avoided for patients with poor prognosis [ 30 , 55 ]. A multi-institutional study on FNAB showed that 87% of patients can be diagnosed with thyroid malignant tumors by FNAB, and 93% of them can be specifically diagnosed with metastases to the thyroid gland [ 56 ].…”

Section: Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Metastases to the Thyroid Gland: What Can We Do?

Tang

Wang

2022

Cancers

View full text Add to dashboard Cite

Metastases to the thyroid gland arise from other malignant tumors such as renal cell carcinoma, colorectal cancer, lung cancer, and breast cancer. In clinical practice, the incidence is low, and the symptoms are not specific, so it is often missed and misdiagnosed. It is finally diagnosed via the comprehensive application of many diagnostic methods, such as ultrasound, fine-needle aspiration biopsy, and immunohistochemistry analysis. Surgery-based comprehensive treatment is often adopted, but because it is usually in the late stage of the primary tumor, the prognosis is poor. In order to better understand the related characteristics of thyroid metastatic cancer and then improve the clinical diagnosis and treatment and the prognosis of patients, in this paper, we systematically summarize the research status of thyroid metastatic cancer.

show abstract

Section: The Primary Tumormentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Metastases to the Thyroid Gland: What Can We Do?

Tang

Wang

2022

Cancers

View full text Add to dashboard Cite

show abstract

“…As per current professional guidelines, CNB is advocated for thyroid nodules wherein repeated FNAB cytology proves to be inadequate, recurrent Bethesda class III cytology, and histological evaluation helps refine the preoperative diagnosis (e.g., suspicion of poorly differentiated or undifferentiated thyroid cancer, thyroid lymphoma, thyroid metastasis) ( 29 ). In patients harboring a clinical doubt of thyroid metastasis, CNB aids in curbing uncertain and erroneous findings, thereby thwarting needless and redundant diagnostic tests and procedures ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Thyroid metastasis from hepatocellular carcinoma: a rare case with diffuse solid occupancy and unusual imaging findings

Feng,

Xue,

Sang

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

BackgroundThyroid metastasis represents a rare occurrence, with commonly observed primary tumors originating from renal cell carcinoma, malignant neoplasms of the gastrointestinal tract, lungs, and breast. However, the metastasis of hepatocellular carcinoma to the thyroid gland remains infrequent. Previous investigations have consistently demonstrated an unfavorable prognosis for patients with malignancies that have metastasized to the thyroid. In this context, we present a noteworthy case of thyroid metastasis from hepatocellular carcinoma (HCC), characterized by a distinct ultrasonographic manifestation of diffuse thyroid lesion, deviating from the previously documented imaging presentations of thyroid metastases in HCC.Case presentationA 62-year-old Chinese female patient was diagnosed with hepatocellular liver cancer in 2019, following which she underwent a radical hepatic resection. Pathological examination revealed HCC located in the right lobe (stage T3bN0M0 IIIB). No additional interventions were administered subsequent to the surgery. After a span of 15 months, the patient presented with dyspnea. Ultrasonographic findings showed diffuse solid infiltration within the thyroid gland, along with tumor thrombi in both internal jugular veins. Computed tomography (CT) scans demonstrated malignant thyroid lesions infiltrating the retropharyngeal space, prevertebral space, and esophageal wall. The subsequent pathology report from the puncture biopsy confirmed the malignant nature of the tumor, and immunohistochemical analysis definitively established its hepatic origin.ConclusionsPatients with a history of HCC should be subjected to long-term monitoring and habitual thyroid ultrasonography. Newly detected thyroid nodules in such patients should be immediately regarded suspect for potential metastatic disease. Even when a nodule doesn’t exhibit malignant characteristics on ultrasound, FNAB should be administered promptly to elucidate the pathological condition. Larger, swiftly multiplying thyroid masses should warrant an immediate CNB. The identification of thyroid metastases, particularly when coupled with peripheral tissue invasion, typically signifies a bleak prognosis.

show abstract

“…Metastatic foci are present at the time of diagnosis in 20% of cases (1). Thyroid metastasis of RCC is rare, and the definitive diagnosis is made by pathological examination of the specimen removed during thyroid surgery (2).…”

Section: Introductionmentioning

confidence: 99%

A rare renal cell cancer clinical presentation late thyroid metastasis

Kartal

Yıldırım

Yıldız

et al. 2023

View full text Add to dashboard Cite

CASE REPORTA 52-year-old male patient was admitted to our clinic complaining of longstanding neck swelling, dyspnea, and dysphagia. In the patient's anamnesis, it was learned that a right nephrectomy was performed for RCC 9 years ago. A thyroid fine-needle aspiration biopsy (FNAB) was performed 7 years ago, and the result was compatible with follicular neoplasia. Although thyroid surgery was recommended, the patient reported not accepting surgery. It was observed that there was no finding in favor of RCC recurrence in the annual routine controls of the patient. On examination, the patient had bilaterally palpable hard nodules and was compatible with laboratory euthyroidism. Bilateral giant nodules were detected in the neck ultrasonography and neck computed tomography (CT) of the patient (Figure 1). FNAB pathology result of the patient was compatible with benign cytology. DISCUSSIONIt should be remembered that patients with a history of RCC presenting with a thyroid nodule may have thyroid metastases, although rare, and metastasis surprise may be encountered in the thyroidectomy material, even if there is no feature in FNAB.

show abstract

Rare presentation of metastatic renal cell carcinoma to thyroid gland: A case report

Cited by 3 publications

References 12 publications

Metastases to the Thyroid Gland: What Can We Do?

Metastases to the Thyroid Gland: What Can We Do?

Case report: Thyroid metastasis from hepatocellular carcinoma: a rare case with diffuse solid occupancy and unusual imaging findings

A rare renal cell cancer clinical presentation late thyroid metastasis

Contact Info

Product

Resources

About