Rare Renal Incidentaloma in Pregnancy: An Unusual Primitive Neuroectodermal Tumor Presentation

Abstract

Peripheral Primitive Neuroectodermal Tumors (PNETs) are rare lesions that arise from outside the central nervous system and normally do not affect the genitourinary system. Primary renal presentations are extremely rare but given their aggressive behavior and characteristic cytomorphologic and genetic features should be considered well-defined distinct clinical entities in order to distinguish them from other primary tumors featuring round cells in the kidney. We report one case of PNET involving the kidney and associated with pregnancy.

Primitive Neuroectodermal Tumor Presenting With a Large Subcapsular Hematoma in Pregnancy: A Case Report and Current Literature Review

“…PNET/EWS in pregnant patients is extremely rare with few case reports in publication discovered during our literature review [ 12 ]. Sites of origin have included the brain, pancreas, ovary, and cervix, with a select number of recent case reports with primary renal tumors [ 12 ].…”

“…PNET/EWS in pregnant patients is extremely rare with few case reports in publication discovered during our literature review [ 12 ]. Sites of origin have included the brain, pancreas, ovary, and cervix, with a select number of recent case reports with primary renal tumors [ 12 ]. Pregnancy represents a unique state in terms of immune function as the mother's body must seek to balance protection from foreign antigens and infections with tolerance of the foreign fetal antigens.…”

Primary primitive neuroectodermal tumor of the cervix confirmed with molecular analysis in a pregnant woman: A case report and literature review

“…Our case was the largest PNET ever reported, and we observed that the tumor grew rapidly during pregnancy and even spontaneous rupture occurred. Some reports show that PNET enlargement is more obvious during pregnancy ( Torga et al, 2015 ; Miao et al, 2018 ). However, the association between the change of hormones during pregnancy and tumor growth needs further confirmation.…”

Unilateral Renal Primitive Neuroectodermal Tumor (PNET)

“…Since then, most features of this neoplasm have been presented through case reports and there are few original articles in this context (6)(7)(8). Based on the literature reviewed, less than 100 cases of PNET of kidney have been reported to date.…”