Rare tumors of esophageal squamous mucosa

Tripathi, Monika; Swanson, Paul E.

doi:10.1111/nyas.13108

Cited by 10 publications

(7 citation statements)

References 63 publications

(140 reference statements)

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“…In contrast, Some previous reports have suggested that the prognosis of esophageal BSCC with locally invasive growth pattern and high proliferation activity is worse than that of typical SCC. [13][14][15] In our study, among the patients who underwent thoracic esophagectomy, the prognostic outcomes of the BSCC group were similar to those of the PSCC and MSCC group. Meanwhile, they were worse than those of the WSCC group, with a significant difference.…”

Section: Discussionsupporting

confidence: 64%

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Comparative Analysis of Clinicopathological Characteristics, Survival Features, and Protein Expression Between Basaloid and Squamous Cell Carcinoma of the Esophagus

Xu¹,

Zhao²,

Tong³

et al. 2021

IJGM

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Background: Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma (SCC) of the esophagus. This study aimed to assess the discrepancy in clinicopathological characteristics and protein expression between esophageal BSCC and typical esophageal SCC. Study Design: We reviewed 40 cases of esophageal BSCC. As controls, 63 welldifferentiated SCC (WSCC) patients, 70 moderately differentiated SCC (MSCC) patients, and 51 poorly differentiated SCC (PSCC) patients were selected. The clinicopathologic characteristics and immunoreactivity of Ki-67, p53, p63, and epidermal growth factor receptor (EGFR) were then evaluated in the BSCC and typical SCC patients. Results:The 5-year survival rates for the BSCC patients were 27.5%. The prognostic outcomes of the BSCC group were similar to those of the PSCC and MSCC groups but worse than that of the WSCC group, with a significant difference (P=0.045). Ki-67 expression was significantly higher in the BSCC group than that in the WSCC group (P < 0.05). Meanwhile, there were no significant differences in the expression of the other molecular markers (p53, p63, and EGFR) between the typical SCC and BSCC groups (P > 0.05). The median survival time of esophageal the BSCC patients with low p53 expression was significantly longer than that of the patients with high p53 expression (P=0.026). Further, the median survival time of the esophageal BSCC patients with high p63 expression was significantly longer than that of the patients with low p63 expression (P=0.041). Meanwhile, Ki-67 and EGFR expressions were not correlated with OS in the BSCC group. Conclusion:Esophageal BSCC has a more clinically virulent course. Notably, p53 and p63 expression are associated with prognosis in BSCC. These findings conject that evaluation of multiple cancer biomarkers might be a promising auxiliary diagnostic indicator in BSCC.

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Section: Discussionsupporting

confidence: 64%

“…In contrast, others have detected similar outcomes. 5,[13][14][15] However, comparative analyses of survival outcomes between esophageal SCC and BSCC have been rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Clinicopathological Characteristics, Survival Features, and Protein Expression Between Basaloid and Squamous Cell Carcinoma of the Esophagus

Xu¹,

Zhao²,

Tong³

et al. 2021

IJGM

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“…Areas of squamous cell carcinoma in situ or OSCC NOS are relative common. The tumour is highly aggressive, with a worse prognosis than OSCC NOS, even though differences are not statistically significant 32 .…”

Section: Oesophageal Squamous Carcinomamentioning

confidence: 88%

Neoplastic and pre-neoplastic lesions of the oesophagus and gastro-oesophageal junction

et al. 2020

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Summary Oesophageal and gastro-oesophageal junction (GOJ) neoplasms, and their predisposing conditions, may be encountered by the practicing pathologist both as biopsy samples and as surgical specimens in daily practice. Changes in incidence of oesophageal squamous cell carcinomas (such as a decrease in western countries) and in oesophageal and GOJ adenocarcinomas (such as a sharp increase in western countries) are being reported globally. New modes of treatment have changed our histologic reports as specific aspects must be detailed such as in post endoscopic resections or with regards to post neo-adjuvant therapy tumour regression grades. The main aim of this overview is therefore to provide an up-to-date, easily available and clear diagnostic approach to neoplastic and pre-neoplastic conditions of the oesophagus and GOJ, based on the most recent available guidelines and literature.

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“…Esophageal squamous cell carcinoma (ESCC) accounts for a majority of esophageal cancer occurring most commonly in the upper two‐thirds of the esophagus. Rare variants of ESCC include: basaloid squamous cell carcinoma (BSCC), spindle cell (squamous) carcinoma (carcinosarcoma), undifferentiated carcinoma, verrucous (squamous) carcinoma, and carcinoma cuniculatum …”

Section: The Role Of Hpv Infection and Hpv Vaccines In Esophageal Squmentioning

confidence: 99%

Risk factors for esophageal cancer: emphasis on infectious agents

El‐Zimaity

Pilato

Ringressi

et al. 2018

Annals of the New York Academy of Sciences

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Risk factors for esophageal cancer include genetic factors (such as tylosis) and infectious agents. A variety of organisms have been implicated in esophageal carcinogenesis, either directly or indirectly. In this review, we explore the normal esophageal flora and how it may be controlled, and also the variety of organisms that may affect esophageal carcinogenesis, either directly or indirectly. The organisms with potential direct effects in squamous cell carcinoma include human papillomavirus (HPV), Epstein-Barr virus, and polyoma viruses. Interestingly, HPV is now implicated in esophageal adenocarcinoma (EAC), not in its initiation but in the development of dysplasia, in which HPV33 in particular has been associated. Indirectly, Helicobacter pylori has been associated with EAC by, initially, causing increased acid secretion that increases acid reflux, and by reducing lower esophageal sphincter pressure, which increases gastroesophageal reflux; the latter increases the risk of Barrett's esophagus, and hence EAC. Conversely, subsequent atrophic gastritis may normalize that risk.

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Rare tumors of esophageal squamous mucosa

Cited by 10 publications

References 63 publications

Comparative Analysis of Clinicopathological Characteristics, Survival Features, and Protein Expression Between Basaloid and Squamous Cell Carcinoma of the Esophagus

Comparative Analysis of Clinicopathological Characteristics, Survival Features, and Protein Expression Between Basaloid and Squamous Cell Carcinoma of the Esophagus

Neoplastic and pre-neoplastic lesions of the oesophagus and gastro-oesophageal junction

Risk factors for esophageal cancer: emphasis on infectious agents

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