2018
DOI: 10.1097/dad.0000000000001135
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Rare Variant of Agminated Spitz Nevi on a Hypopigmented Background and Segmental Distribution: Case Report and Review of Literature

Abstract: Spitz nevus is a type of melanocytic nevus that can arise as a solitary lesion or as multiple lesions either disseminated or agminated (grouped) in different skin backgrounds (eg, grossly normal, hyperpigmented, or hypopigmented). Agminated Spitz nevi have been rarely reported and are even rarer in a background of hypopigmented skin. We present the case of a 2-month-old girl with multiple, grouped, dome-shaped, red papules arising on a hypopigmented patch with a segmental distribution. Biopsy of 2 lesions show… Show more

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Cited by 5 publications
(6 citation statements)
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“…Agminated Spitz nevi are a rare entity, and their management is challenging considering the young age of the patients, the tumors’ uncertain malignant potential, and variability in dermoscopic and clinical presentation 1–4 . This was particularly evident in our case, where the lesions presented with varying and atypical dermoscopic patterns.…”
Section: Discussionmentioning
confidence: 80%
“…Agminated Spitz nevi are a rare entity, and their management is challenging considering the young age of the patients, the tumors’ uncertain malignant potential, and variability in dermoscopic and clinical presentation 1–4 . This was particularly evident in our case, where the lesions presented with varying and atypical dermoscopic patterns.…”
Section: Discussionmentioning
confidence: 80%
“…Despite Spitz nevi usually present as solitary cutaneous lesions, multiple Spitz nevi can be divided into agminated (ASN) or disseminated [45]. To date, 20 cases of disseminated (or multiple or eruptive) Spitz nevi [45,[63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82] have been reported in the literature, while, regarding agminated Spitz nevi, a total of 39 cases have been reported [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][46][47][48][49][50][51][52][53][54][55][56]…”
Section: Discussionmentioning
confidence: 99%
“…Spitz nevi typically possess distinct patterns of genetic aberrations that differ from conventional melanocytic nevi and melanoma. 7,8 Whereas common acquired nevi and melanoma typically…”
Section: Discussionmentioning
confidence: 99%
“…Spitz nevi typically possess distinct patterns of genetic aberrations that differ from conventional melanocytic nevi and melanoma 7,8 . Whereas common acquired nevi and melanoma typically demonstrate characteristic BRAF mutations, NRAS mutations, or inactivation of NF1, Spitz nevi harbor HRAS mutations, inactivation of BAP1 and BRAF mutations, or genomic rearrangements involving the kinases ALK, ROS1, NTRK1, BRAF, RET, and MET 8 .…”
Section: Discussionmentioning
confidence: 99%