Rare variant of Guillain-Barré syndrome after chikungunya viral fever

Hameed, Sajid; Khan, Sara

doi:10.1136/bcr-2018-228845

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…During the Chikungunya outbreak at Reunion Island, France in 2005–2006, Lebrun et al reported 2 cases of GBS with antecedent Chikungunya infection. In both the patients, Chikungunya infection was confirmed by the presence anti-Chikungunya IgM and IgG antibodies in serum and CSF [ 45 – 53 ]. Antecedent Chikungunya infections in GBS reported globally in the last two decades are depicted in ( Table 1 ) .…”

Section: Literature Review: Antecedent Infections In Gbsmentioning

confidence: 99%

Guillain-barré syndrome (GBS) with antecedent chikungunya infection: a case report and literature review

V.,

Pattanaik,

Marate

et al. 2024

Neurol. Res. Pract.

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Guillain-Barré Syndrome (GBS) is an autoimmune neuropathy. Antecedent infections have been seen to be significant triggering factors for developing GBS. Among them, arboviral infections are rapidly gaining importance as significant triggers, especially in the areas where they are endemic. Chikungunya, an arboviral infection that usually causes a self-limiting acute febrile illness can lead to GBS as one its severe complications. Herein, we describe a case of a 21-year-old female who presented with weakness in all four limbs and paresthesia. Nerve conduction study and cerebrospinal fluid (CSF) analysis showed axonal, demyelinating motor and sensory neuropathy with albuminocytological dissociation indicating Acute Motor and Sensory Axonal Neuropathy (AMSAN) variant of GBS. Serum IgM antibodies against ganglioside GM1 were detected. Anti-Chikungunya IgM antibodies were found in both serum and CSF samples. The patient was initiated with Intravenous Immunoglobulin (IVIG) therapy. In view of hypoxia, she was intubated and was on mechanical ventilation. After 2 weeks of being comatose, the patient gradually improved and was discharged with no sequelae.A literature review on antecedent infections in GBS is presented alongside the case report to better understand the association of GBS with antecedent infections, especially the endemic arboviral infections like Chikungunya, Dengue and Zika. This will help in reinforcing the significance of having robust surveillance and public health control measures for infectious diseases.

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Section: Literature Review: Antecedent Infections In Gbsmentioning

confidence: 99%

Guillain-barré syndrome (GBS) with antecedent chikungunya infection: a case report and literature review

V.,

Pattanaik,

Marate

et al. 2024

Neurol. Res. Pract.

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“…GBS is often preceded by an infection with Campylobacter jejunii , mycoplasma pneumoniae , EBV, CMV, influenza-A, or hepatitis-E [ 42, 45 ]. Micro-organisms more rarely triggering GBS include scrub typhus (Tsutsugamishi fever) [ 46 ], Chikungunya [ 47 ], rubella virus [ 45 ], VZV, Toscana virus, hepatitis-C, hepatitis-A, hepatitis-B, West Nile, COVID-19, SARS-CoV-2, or Zika [ 48 ]. Rare, non-infectious triggers of GBS include hyponatriemia [ 49 ], bariatric surgery [ 50 ], lupus, pregnancy [ 42 ], or bacterial meningitis [ 51 ].…”

Section: Acquired Neuropathiesmentioning

confidence: 99%

Orphan Peripheral Neuropathies

Finsterer

Löscher

Wanschitz

et al. 2020

Journal of Neuromuscular Diseases

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Objectives: Generally, neuropathies of peripheral nerves are a frequent condition (prevalence 2–3%) and most frequently due to alcoholism, diabetes, renal insufficiency, malignancy, toxins, or drugs. However, the vast majority of neuropathies has orphan status. This review focuses on the etiology, frequency, diagnosis, and treatment of orphan neuropathies. Methods: Literature review Results: Rareness of diseases is not uniformly defined but in the US an orphan disease is diagnosed if the prevalence is <1:200000, in Europe if <5:10000. Most acquired and hereditary neuropathies are orphan diseases. Often the causative variant has been reported only in a single patient or family, particularly the ones that are newly detected (e.g. SEPT9, SORD). Among the complex neuropathies (hereditary multisystem disorders with concomitant neuropathies) orphan forms have been reported among mitochondrial disorders (e.g. NARP, MNGIE, SANDO), spinocerebellar ataxias (e,g, TMEM240), hereditary spastic paraplegias (e.g UBAP1), lysosomal storage disease (e.g. Schindler disease), peroxisomal disorders, porphyrias, and other types (e.g. giant axonal neuropathy, Tangier disease). Orphan acquired neuropathies include the metabolic neuropathies (e.g. vitamin-B1, folic acid), toxic neuropathies (e.g. copper, lithium, lead, arsenic, thallium, mercury), infectious neuropathies, immune-mediated (e.g. Bruns-Garland syndrome), and neoplastic/paraneoplastic neuropathies. Conclusions: Though orphan neuropathies are rare per definition they constitute the majority of neuropathies and should be considered as some of them are easy to identify and potentially treatable, as clarification of the underlying cause may contribute to the knowledge about etiology and pathophysiology of these conditions, and as the true prevalence may become obvious only if all ever diagnosed cases are reported.

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“…The arthralgia can persist for months after the acute infection, characterizing the main chronic incapacitating symptom of those infections. However, both viruses have been associated with more severe neurological manifestations, such as meningo-encephalitis, Guillain-Barré syndrome, acute disseminated encephalomyelitis (ADEM), and severe myelitis, with increasing reports of neuro-CHIKV in endemic areas such as Brazil ( Bandeira et al., 2016 ; Balavoine et al., 2017 ; Khatri et al., 2018 ; Maria et al., 2018 ; Simon et al., 2018 ; Hameed and Khan, 2019 ; Silva et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika Viruses

Geddes

Brustolini

Cavalcante

et al. 2021

Front. Cell. Infect. Microbiol.

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Arboviruses pose a major threat throughout the world and represent a great burden in tropical countries of South America. Although generally associated with moderate febrile illness, in more severe cases they can lead to neurological outcomes, such as encephalitis, Guillain-Barré syndrome, and Congenital Syndromes. In this context astrocytes play a central role in production of inflammatory cytokines, regulation of extracellular matrix, and control of glutamate driven neurotoxicity in the central nervous system. Here, we presented a comprehensive genome-wide transcriptome analysis of human primary astrocytes infected with Chikungunya, Mayaro, Oropouche, or Zika viruses. Analyses of differentially expressed genes (DEGs), pathway enrichment, and interactomes have shown that Alphaviruses up-regulated genes related to elastic fiber formation and N-glycosylation of glycoproteins, with down-regulation of cell cycle and DNA stability and chromosome maintenance genes. In contrast, Oropouche virus up-regulated cell cycle and DNA maintenance and condensation pathways while down-regulated extracellular matrix, collagen metabolism, glutamate and ion transporters pathways. Zika virus infection only up-regulated eukaryotic translation machinery while down-regulated interferon pathways. Reactome and integration analysis revealed a common signature in down-regulation of innate immune response, antiviral response, and inflammatory cytokines associated to interferon pathway for all arboviruses tested. Validation of interferon stimulated genes by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) corroborated our transcriptome findings. Altogether, our results showed a co-evolution in the mechanisms involved in the escape of arboviruses to antiviral immune response mediated by the interferon (IFN) pathway.

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Rare variant of Guillain-Barré syndrome after chikungunya viral fever

Cited by 8 publications

References 13 publications

Guillain-barré syndrome (GBS) with antecedent chikungunya infection: a case report and literature review

Guillain-barré syndrome (GBS) with antecedent chikungunya infection: a case report and literature review

Orphan Peripheral Neuropathies

Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika Viruses

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