RAS genes influence exercise-induced left ventricular hypertrophy: an elite athletes study

Fatini, Cinzia; Guazzelli, R; Manetti, Paolo; Battaglini, B; Gensini, Francesca; Vono, Roberta; Toncelli, Loira; Zilli, Paola; Capalbo, Andrea; Abbate, Rosanna; Gensini, Gian Franco; Galanti, Giorgio

doi:10.1097/00005768-200011000-00008

Cited by 61 publications

(45 citation statements)

References 20 publications

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“…The power of the performed test ( = 0.05) was 0.947, above the desired power of 0.80. In fact, some studies have associated the D allele with greater increased in left ventricular mass (Fatini et al 2000;Hernandez et al 2003;Montgomery et al 1997;Kasikcioglu et al 2004), higher VO 2max (Hagberg et al 1998) and with diVerences in skeletal muscle strength gain (Folland et al 2000;Williams et al 2005). Moreover, Zhang et al (2003) showed linear trends for decreases in type I Wbers and increases in type IIb Wbers from ACE II to ID and to DD genotypes.…”

Section: Discussionmentioning

confidence: 99%

“…Compared to the I allele, the presence of the D allele has been linked to an increased circulating (Cambien et al 1994;Rigat et al 1990) as well as tissue ACE activity (Costerousse et al 1993;Danser et al 1995). The D allele has been also associated with a higher risk for myocardial infarction and heart failure (Ledru et al 1998) and with exerciseinduced left ventricular hypertrophy (Fatini et al 2000;Hernandez et al 2003;Montgomery et al 1997;Kasikcioglu et al 2004).…”

Section: Introductionmentioning

confidence: 99%

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Association between ACE D allele and elite short distance swimming

et al. 2009

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The influence of ACE gene on athletic performance has been widely explored, and most of the published data refers to an I/D polymorphism leading to the presence (I allele) or absence (D allele) of a 287-bp sequence in intron 16, determining ACE activity in serum and tissues. A higher I allele frequency has been reported among elite endurance athletes, while the D allele was more frequent among those engaged in more power-orientated sports. However, on competitive swimming, the reproducibility of such associations is controversial. We thus compared the ACE genotype of elite swimmers with that of non-elite swimming cohort and of healthy control subjects. We thus sought an association of the ACE genotype of elite swimmers with their competitive distance. 39 Portuguese Olympic swimming candidates were classified as: short (<200 m) and middle (400-1,500 m) distance swimmers, respectively. A group of 32 non-elite swimmers were studied and classified as well, and a control group (n = 100) was selected from the Portuguese population. Chelex 100 was used for DNA extraction and genotype was determined by PCR-RFLP methods. We found that ACE genotype distribution and allelic frequency differs significantly by event distance only among elite swimmers (P < or = 0.05). Moreover, the allelic frequency of the elite short distance swimmers differed significantly from that of the controls (P = 0.021). No associations were found between middle distance swimmers and controls. Our results seem to support an association between the D allele and elite short distance swimming.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between ACE D allele and elite short distance swimming

et al. 2009

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“…However these findings could not be replicated in a similar US Army recruit study (Sonna et al 2001). Furthermore, cardiac hypertrophy has been associated with the D allele (Fatini et al 2000;Montgomery et al 1997), while in contrast, the I allele was associated with a greater whole-body anabolic response to army training (Montgomery et al 1999). These types of training are, however, not comparable with a highly standardized and focused high-resistance strength training program as in the present study.…”

Section: Angiotensin-converting Enzymementioning

confidence: 93%

“…ACE generates angiotensin II, which is a growth factor for cardiac myocytes and fibroblasts (Sadoshima et al 1993) and it degrades kinins that inhibit growth in cardiac myocytes (Ishigai et al 1997). Montgomery et al (1997) and Fatini et al (2000) reported that cardiac and left ventricular mass hypertrophy in response to physical exercise were associated with the ACE D allele. Furthermore, the enzyme is not only present in myocardium and smooth muscle cells, but also in human skeletal muscle (Reneland and Lithell 2001).…”

Section: Angiotensin-converting Enzymementioning

confidence: 99%

Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training

et al. 2004

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This study explores the associations between polymorphisms in two candidate genes-myostatin gene (MSTN or GDF8) and angiotensin-converting enzyme (ACE) gene-with interindividual differences in human muscle mass and strength responses to strength training. The MSTN AluI A55T (exon 1), BanII K153R, TaqI E164 K and BstNI P198A (all in exon 2) markers and the ACE insertion (I)/deletion (D) polymorphism were typed in 57 males [22.4 (3.7) years] who participated in a 10-week, high-resistance training program for the elbow flexors. Maximal strength, and maximal isometric and concentric elbow flexor torques were measured at baseline and after training. Information on muscle cross-sectional area of the upper arm was obtained by computer tomography scans. Only one individual was heterozygous for the MSTN BanII K153R variant. No allelic variant was detected at the other MSTN sites in this population. For the ACE I/D polymorphism, no evidence was found for an association of the D or I allele with baseline strength, isometric and concentric torque or arm muscle cross-sectional area [analysis of covariance (ANCOVA) 0.25< P<0.97]. Responses to the strength-training program were not associated with the ACE I/D genotype (ANCOVA 0.057< P<0.70). Borderline significance was found for larger strength gains in dynamic flexion torques for I/I genotypes. This study therefore does not support the hypothesis that an increased muscle fiber hypertrophic effect of strength training is present in D-allele carriers.

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“…Two recent studies showed a higher proportion of the R allele of the R577X polymorphism in the α-actinin-3 (ACTN3 ) gene, and of the DD genotype of the Insertion(I)/Deletion(D) polymorphism in the angiotensin-converting enzyme (ACE) gene, in world-class professional soccer players compared with non-athletic controls and elite endurance athletes [12,23]. In addition, Fatini et al showed that the ACE D allele is associated with training-induced changes in the left ventricular mass of elite Italian soccer players [7]. However, another study found no difference in ACE I/D genotype frequencies between elite Korean soccer players and non-athletic controls [19].…”

Section: Introductionmentioning

confidence: 99%

The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player's Status

et al. 2012

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The NOS3-786 T/C polymorphism (rs2070744) is a candidate to explain individual variations in sports related phenotypes. We determined the genotype and allele frequency of NOS3-786 T/C in a group of 60 male professional elite soccer players.Their results were compared with those of 100 world-class endurance athletes, 53 elite power athletes, and 100 sedentary, healthy men (controls) of the same Caucasian (Spanish) origin. There were significant differences in genotype frequencies between soccer players, controls, endurance and power elite athletes (all P≤0.02). These results were confirmed when we analysed allelic frequencies (all P<0.01). The likelihood of having the C allele was higher in soccer players compared with (i) controls [odds ratio (OR), 2.165, 95% confidence interval (CI): 1.362-3.441], (ii) endurance athletes (OR:1.879, 95%CI: 1.184-2.984), and (iii) power athletes (OR: 4.032, 95%CI: 2.307-7.047). In conclusion, the -786C allele is associated with the status of being an elite soccer player, compared with non-athletic controls and also with elite endurance and power athletes. More research is needed in other groups of elite soccer players in order to replicate the results of the present study.

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RAS genes influence exercise-induced left ventricular hypertrophy: an elite athletes study

Abstract: In this study, we provide the evidence that soccer play does not select athletes on genotype basis. Training-induced LV mass changes in male elite athletes are significantly associated with the presence of ACE D allele, but not of AT1R C allele.

Cited by 61 publications

References 20 publications

Association between ACE D allele and elite short distance swimming

Association between ACE D allele and elite short distance swimming

Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training

The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player's Status

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