2023
DOI: 10.1101/2023.08.30.555648
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Ras-mediated homeostatic control of front-back signaling dictates cell polarity

Yiyan Lin,
Dhiman Sankar Pal,
Parijat Banerjee
et al.

Abstract: Studies in the model systems, Dictyostelium amoebae and HL-60 neutrophils, have shown that local Ras activity directly regulates cell motility or polarity. Localized Ras activation on the membrane is spatiotemporally regulated by its activators, RasGEFs, and inhibitors, RasGAPs, which might be expected to create a stable front and back, respectively, in migrating cells. Focusing on C2GAPB in amoebae and RASAL3 in neutrophils, we investigated how Ras activity along the cortex controls polarity. Since existing g… Show more

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Cited by 2 publications
(3 citation statements)
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“…Emerging studies in many different types of cells have unveiled fascinating phenomena underlying these protrusive events. Waves of signal transduction and cytoskeletal activity propagate across the cell membrane and cortex matching closely the protrusive events [16][17][18][19][20][21][22][23][24] . Perturbation of the wave behavior has a predictable, causal effect on the protrusions and dependent physiological events [25][26][27] .…”
Section: Introductionmentioning
confidence: 84%
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“…Emerging studies in many different types of cells have unveiled fascinating phenomena underlying these protrusive events. Waves of signal transduction and cytoskeletal activity propagate across the cell membrane and cortex matching closely the protrusive events [16][17][18][19][20][21][22][23][24] . Perturbation of the wave behavior has a predictable, causal effect on the protrusions and dependent physiological events [25][26][27] .…”
Section: Introductionmentioning
confidence: 84%
“…A stable HL-60 cell line co-expressing CIBN-CAAX and LifeActmiRFP703 was generated using a lentiviral-based approach described in previous studies 23,28 . In this dual expressing cell line, we stably expressed CRY2PHR-mCherry-AldolaseA via transposon integration 23,28,54 .…”
Section: Methodsmentioning
confidence: 99%
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