Ras-related proteins (Rab) play significant roles in sperm motility and capacitation status

Bae, Jeong-Won; Yi, Jun Koo; Jeong, Eunju; Lee, Woojin; Hwang, Ju-Mi; Kim, Dae-Hyun; Ha, Jae Jung; Kwon, Woo-Sung

doi:10.1016/j.repbio.2022.100617

Cited by 17 publications

(31 citation statements)

References 36 publications

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“…Rab proteins that are concerned in Golgi trafficking play important roles in preserving and establishing the Golgi structure in eukaryotic cells. [4][5][6]16]. In particular, Rab proteins induce acrosome biogenesis from the Golgi apparatus during spermatogenesis [17][18][19], and they are involved in acrosome exocytosis after capacitation [7,20,21].…”

Section: Resultsmentioning

confidence: 99%

“…The acrosome is derived from the Golgi apparatus and a lysosome-like structure is established during spermatogenesis [4,16]. Because Rab proteins are involved in the establishment of the acrosome by regulating Golgi trafficking, they are key proteins in acrosome formation [4][5][6]16]. Almost all Rab proteins are expressed in the sperm head and tail [6,7,22].…”

Section: Correlation Between Expression Of Rab Proteins and Litter Si...mentioning

confidence: 99%

“…Rab proteins are known to be involved in acrosomal biogenesis and exocytosis. Rab proteins play a role in preserving and establishing the Golgi structure, and the Golgi apparatus is derived from the acrosome during spermatogenesis [4][5][6]. In addition, Rab proteins are not only linked to acrosome formation and reaction but also to sperm motility capacitation conditions [5].…”

Section: Introductionmentioning

confidence: 99%

“…Rab proteins play a role in preserving and establishing the Golgi structure, and the Golgi apparatus is derived from the acrosome during spermatogenesis [4][5][6]. In addition, Rab proteins are not only linked to acrosome formation and reaction but also to sperm motility capacitation conditions [5]. Thus, the importance of the Rab proteins for male reproduction has been emphasized by several studies to identify the function of Rab proteins in spermatozoa of humans and animals [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Prediction of male fertility using Ras-related proteins

Bae¹,

Hwang²,

Kwon³

2022

J Anim Sci Technol

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Jeong-Won Bae (https://orcid.org/0000-0002-7030-7767) Ju-Mi Hwang (https://orcid.org/0000-0003-1776-9759) Woo-Sung Kwon (https://orcid.org/0000-0002-0848-7189) Competing interestsNo potential conflict of interest relevant to this article was reported. Funding sourcesState funding sources (grants, funding sources, equipment, and supplies). Include name and number of grant if available.This study was conducted with the support of the Gyeongsangbukdo agricultural and fishery R&D activation project Authors' contributionsPlease specify the authors' role using this form.

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Section: Resultsmentioning

confidence: 99%

Section: Correlation Between Expression Of Rab Proteins and Litter Si...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prediction of male fertility using Ras-related proteins

Bae¹,

Hwang²,

Kwon³

2022

J Anim Sci Technol

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“…Rab proteins were located in the sperm head and tail. Ras is correlated with various sperm motility patterns and motion kinematics before capacitation [ 86 ].…”

Section: Discussionmentioning

confidence: 99%

Age-Dependent Variations in Functional Quality and Proteomic Characteristics of Canine (Canis lupus familiaris) Epididymal Spermatozoa

Zmudzinska

Wiśniewski

Młynarz

et al. 2022

IJMS

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Increased male age is associated with a significant reduction in semen quality. Little is known about the sperm proteome changes resulting from the aging process. This study aimed to investigate the relationship between the functional quality and proteome of epididymal spermatozoa of dogs that were differing in age. The study was conducted on 30 male dogs that were divided into three age groups. G1—12 to 41 months old, G2—42 to 77 months old, and G3—78 to 132 months old. The sperm samples were assessed using a computer-assisted semen analysis (CASA). The epididymal sperm proteins were analyzed using gel electrophoresis (SDS-PAGE), nano-liquid chromatography coupled to quadrupole time of flight mass spectrometry (NanoUPLC-Q-TOF/MS) and bioinformatic tools. The sperm quality parameters were significantly lower in older dogs. NanoUPLC-Q-TOF/MS identification resulted in 865 proteins that were found in the G1, 472 in G2, and 435 in G3. There were seven proteins that were present in all three age groups, and four of them (ACTB, CE10, NPC2, CRISP2) showed significant changes among the studied groups. Age-dependent variations were detected in the sperm proteome composition and were related to important metabolite pathways, which might suggest that several proteins are implicated in sperm maturation and could be potential aging biomarkers.

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Evaluation of sperm quality and male fertility: The use of molecular markers in boar sperm and seminal plasma

Llavanera

2024

Animal Reproduction Science

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Ras-related proteins (Rab) play significant roles in sperm motility and capacitation status

Cited by 17 publications

References 36 publications

Prediction of male fertility using Ras-related proteins

Prediction of male fertility using Ras-related proteins

Age-Dependent Variations in Functional Quality and Proteomic Characteristics of Canine (Canis lupus familiaris) Epididymal Spermatozoa

Evaluation of sperm quality and male fertility: The use of molecular markers in boar sperm and seminal plasma

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