2022
DOI: 10.1172/jci.insight.155676
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Rasa3 deficiency minimally affects thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance

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Cited by 9 publications
(4 citation statements)
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“…Lee et al. reported that platelets from mice bearing a hypomorphic Rasa3 mutant were entrapped in the spleen and liver, and subsequently they were engulfed by macrophages, presumably by talin1-dependent activation of integrin αIIbβ3, thus causing thrombocytopenia ( 46 ). The DKO T cells entrapped in the pulmonary capillaries probably transmigrate into the lung parenchyma, leading to accumulation in lung perivascular lymphatics that exclusively express CCL21.…”
Section: Discussionmentioning
confidence: 99%
“…Lee et al. reported that platelets from mice bearing a hypomorphic Rasa3 mutant were entrapped in the spleen and liver, and subsequently they were engulfed by macrophages, presumably by talin1-dependent activation of integrin αIIbβ3, thus causing thrombocytopenia ( 46 ). The DKO T cells entrapped in the pulmonary capillaries probably transmigrate into the lung parenchyma, leading to accumulation in lung perivascular lymphatics that exclusively express CCL21.…”
Section: Discussionmentioning
confidence: 99%
“…Inactivation of Rasa3 in mouse had a megakaryocytic dysplasia accompanied with a severe thrombocytopenia, and these megakaryocyte alterations were related to an increased active Rap1 level and a constitutive integrin activation [94,95]. However, a new molecular mechanism has been found that dysregulated integrin signaling in the Rasa3-mutant mouse model may contribute to increased platelet clearance in various inherited and acquired thrombocytopenia [96].…”
Section: The Other Members Of Ras Subfamilymentioning
confidence: 99%
“…RASA3 is a ubiquitously expressed GTPase‐activating protein that inhibits R‐Ras and Rap1 activity. 17 , 18 , 19 , 20 , 21 Global loss of RASA3 expression in mice is embryonically lethal due to failure of vasculogenesis and severe bleeding. 22 Conditional endothelial cell‐specific knockout of RASA3 in mice recapitulates failure of vascular lumen formation and decreased vascular complexity.…”
Section: Introductionmentioning
confidence: 99%
“…RASA3 is a ubiquitously expressed GTPase‐activating protein that inhibits R‐Ras and Rap1 activity 17–21 . Global loss of RASA3 expression in mice is embryonically lethal due to failure of vasculogenesis and severe bleeding 22 .…”
Section: Introductionmentioning
confidence: 99%