Raspberry anthocyanin consumption prevents diet-induced obesity by alleviating oxidative stress and modulating hepatic lipid metabolism

Abstract

Evidence indicates that raspberries have beneficial effects on chronic diseases. The objective of this study was to examine the beneficial effects of raspberry anthocyanin (RA) on high fat diet-induced obesity and investigate the underlying molecular mechanism. C57BL/6 mice were administered a low-fat diet, high-fat diet, and high-fat diet supplemented with RA at a dose of 200 mg kg-1 of food for 12 weeks. It was found that RA reduced the body weight gain by 63.7%. Furthermore, RA significantly elevated serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities and fecal butyric acid level, remarkably reduced the serum and hepatic lipid profiles, and markedly down-regulated the expression of the tumor necrosis factor α (TNFα), interleukin-6 (IL-6), and nuclear factor κB (NF-κB) genes. Metabolomics analysis conducted using gas chromatography time-of-flight mass spectrometry (GC-TOF/MS) indicated that RA administration promoted the recovery of metabolites involved in glycerophospholipid metabolism, insulin signaling pathway, and glutathione metabolism in the livers of obese mice. These findings suggest that RA may ameliorate diet-induced obesity by alleviating oxidative stress and modulating lipid metabolism.

Blueberry intake included in hypocaloric diet decreases weight, glucose, cholesterol, triglycerides and adenosine levels in obese subjects

“…The current results are in line with previous reports by showing the positive effects of consuming berries in obesity control as well as in decreasing inflammatory-related molecules (Kowalska, Olejnik, Szwajgier, & Olkowicz, 2017;Leu et al, 2017;Noratto et al, 2016;Vendrame, Tsakiroglou, Kristo, Schuschke, & Klimis-Zacas, 2016;Wu et al, 2013;Wu, Yang, et al, 2018). In this regard, rat models of obesity respond positively if animals are under diet enriched with blueberries (Aranaz et al, 2017).…”

“…Literature suggests that blueberries consumption has been associated with amelioration of obesity as well as diminution of obesity-related pro-inflammatory molecules (Badillo et al, 2017;Burnstock & Gentile, 2018;Cáceres-Medina et al, 2015;Margalef et al, 2017;Noratto et al, 2016;Oviedo-Solís, Cornejo-Manzo, & Murillo-Ortiz, 2018;Pandolfi et al, 2015;Wyckoff, Evans, Manasse, Butryn, & Forman, 2017). Thus, we included blueberries as beneficial health-promoting food in hypocaloric diet as suggested by others (Wu, Yang, et al, 2018;Zhang, Ma, Luo, & Li, 2018). Therefore, to evaluate whether a pathological state of obesity would be influenced by blueberries consumption (50 g/day), this food item was included in the group of subjects.…”

Obesity-associated Pathways of Anthocyanins

“…But, there are also the findings in which the different correlation between leptin and adiponectin was found. For example, adiponectin levels in the mice fed with the anthocyanin-rich foods increased while leptin secretion is decreased (Wu et al, 2016b(Wu et al, , 2018.…”

Influence of Diet‐Induced Obesity on the Bioavailability and Metabolism of Raspberry Ketone (4‐(4‐Hydroxyphenyl)‐2‐Butanone) in Mice

“…Raspberry ketone (RK), 4‐( p ‐hydroxyphenyl)‐2‐butanone, is a naturally occurring aromatic phenolic compound derived from red raspberries ( Rubus idaeus ), accounting for the characteristic “raspberry flavor.” In small quantities, it is classified as a generally recognized as safe synthetic flavoring agent by the US Food and Drug Administration; [ 1–6 ] at higher doses, RK has been found to exhibit in vitro anti‐lipogenic and in vivo weight‐reducing activities. [ 2,7,8 ] Previously, we demonstrated that male C57BL/6J mice orally administered with RK attenuated high‐fat diet (HFD)‐induced adipose gain and metabolic alteration associated with obesity.…”