Raspberry Ketone: An Evidence-Based Systematic Review by the Natural Standard Research Collaboration

UlbrichtCatherine,; CatapangMarisa,; ConquerJulie,; CostaDawn,; CulwellSamantha,; D’AuriaDenise,; IsaacRichard,; LeCindy,; MariniErica,; MillerAnne,; MintzerMeredith,; NguyenMelissa,; SalessesKate,

doi:10.1089/act.2013.19201

Cited by 9 publications

(6 citation statements)

References 9 publications

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“…However, at this time there are no in vivo studies to address these possible adverse effects with RK. Considering the very high recommended daily doses between 100 and 1400 mg, it is vital to evaluate the hazards that may occur with daily supplementation of RK [ 16 , 75 , 76 ].…”

Section: Pharmacokinetic (Adme) and Safety Profile Of Rkmentioning

confidence: 99%

Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020

Rao

Kurakula

Mamidipalli³

et al. 2021

Plants

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Raspberry ketone (RK) is an aromatic phenolic compound naturally occurring in red raspberries, kiwifruit, peaches, and apples and reported for its potential therapeutic and nutraceutical properties. Studies in cells and rodents have suggested an important role for RK in hepatic/cardio/gastric protection and as an anti-hyperlipidemic, anti-obesity, depigmentation, and sexual maturation agent. Raspberry ketone-mediated activation of peroxisome proliferator-activated receptor-α (PPAR-α) stands out as one of its main modes of action. Although rodent studies have demonstrated the efficacious effects of RK, its mechanism remains largely unknown. In spite of a lack of reliable human research, RK is marketed as a health supplement, at very high doses. In this review, we provide a compilation of scientific research that has been conducted so far, assessing the therapeutic properties of RK in several disease conditions as well as inspiring future research before RK can be considered safe and efficacious with limited side effects as an alternative to modern medicines in the treatment of major lifestyle-based diseases.

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Section: Pharmacokinetic (Adme) and Safety Profile Of Rkmentioning

confidence: 99%

Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020

Rao

Kurakula

Mamidipalli³

et al. 2021

Plants

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“…RK is the key compound responsible for the raspberry flavor. Due to its sweetening effect, RK is widely used as a flavoring agent in cosmetics, perfumes, and foods with health functions . RK is marketed as a health supplement for managing and controlling body weight.…”

Section: Introductionmentioning

confidence: 99%

Raspberry Ketone Attenuates Hepatic Fibrogenesis and Inflammation via Regulating the Crosstalk of FXR and PGC-1α Signaling

Jiang,

Dou,

Xuan

et al. 2024

J. Agric. Food Chem.

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Hepatic fibrosis is a compensatory response to chronic liver injury and inflammation, and dietary intervention is recommended as one of the fundamental prevention strategies. Raspberry ketone (RK) is an aromatic compound first isolated from raspberry and widely used to prepare food flavors. The current study investigated the hepatoprotection and potential mechanism of RK against hepatic fibrosis. In vitro, hepatic stellate cell (HSC) activation was stimulated with TGF-β and cultured with RK, farnesoid X receptor (FXR), or peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) agonist or inhibitor, respectively. In vivo, C57BL/6 mice were injected intraperitoneally with thioacetamide (TAA) at 100/200 mg/kg from the first to the fifth week. Mice were intragastrically administrated with RK or Cur once a day from the second to the fifth week. In activated HSCs, RK inhibited extracellular matrix (ECM) accumulation, inflammation, and epithelial−mesenchymal transition (EMT) process. RK both activated FXR/PGC-1α and regulated their crosstalk, which were verified by their inhibitors and agonists. Deficiency of FXR or PGC-1α also attenuated the effect of RK on the reverse of activated HSCs. RK also decreased serum ALT/ AST levels, liver histopathological change, ECM accumulation, inflammation, and EMT in mice caused by TAA. Double activation of FXR/PGC-1α might be the key targets for RK against hepatic fibrosis. Above all, these discoveries supported the potential of RK as a novel candidate for the dietary intervention of hepatic fibrosis.

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“…It's among the most costly natural flavoring ingredients on the market. The natural substance may be expensive, costing up to $20,000 per kilogram [6] . Synthetic RK is less expensive, with various estimates from several dollars per pound to a quarter of the natural product's price.…”

Section: Introductionmentioning

confidence: 99%

Raspberry ketone: an emerging molecule for treating depression and associated symptoms - molecular docking and pharmacokinetics studies

Kumar

Garg

et al. 2022

ijhs

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After analyzing multiple pharmaceutical databases like ScienceDirect, PubMed, Google Scholar, and others, it was discovered that RK has yet to be linked to any anti-depressant action. The primary goal of this work was to use in-silico techniques to investigate the anti-depressant capability of RK against three major targets (monoamine oxidases, MAOs; human serotonin transporter, SERT; and serotonin receptors, 5HTs). Moreover, prediction of drug-likeliness, bioavailability, and pharmacokinetics of RK has been done using online computational tools (SwissADME, SwissTargetPrediction, and SwissBioisostere). Thein silico study indicated the emerging role of RK in the management of clinical depression. The pharmacokinetic studies, target prediction studies against 3 species, and biosisosteric-based studies also supported the possibilities of lead development. The study will open new avenues of application of this low-molecular-weight-ligand (LMWL) for the clinicians, chemists, and other scientific professionals in context to emerging depression challenges.

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Raspberry Ketone: An Evidence-Based Systematic Review by the Natural Standard Research Collaboration

Cited by 9 publications

References 9 publications

Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020

Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020

Raspberry Ketone Attenuates Hepatic Fibrogenesis and Inflammation via Regulating the Crosstalk of FXR and PGC-1α Signaling

Raspberry ketone: an emerging molecule for treating depression and associated symptoms - molecular docking and pharmacokinetics studies

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