RAST in the diagnosis of hypersensitivity to dog and cat allergens A comparison of different extract preparations with clinical history, skin test and provocation tests

Abstract

Summary A comparison was made of clinical signs and provocation tests with the RAST for allergy to dog in eight and cat in twenty patients. Twenty‐two had high IgE levels and all gave positive reactions to provocation tests. A commercially available dog epithelium extract gave more positive RASTs than five other dog allergen preparations, and there were no positive reactions to dog serum. The RAST was negative in patients with a low degree of sensitivity. All twenty patients allergic to cat gave positive intracutaneous test reactions and in the RAST the cat epithelial allergen showed 90% agreement with the in vivo findings.

The role of allergen-specific IgE in predicting allergic symptoms on dog and cat exposure among Korean pet exhibition participants

“…15 Since the introduction of these 2 methods into clinical practice in the late 20th century, their diagnostic performance has been evaluated and compared extensively. 8,[16][17][18][19][20] Nevertheless, their diagnostic value has not been established yet, especially for allergies to dogs and cats. In a previous study, only 38.8% of dog owners who suffered from allergic symptoms during exposure to their dog showed positive results for dog allergy in SPT, so did 31.1% of cat owners for cat allergy.…”

Defining allergens of mammalian origin

“…Allergenic activity has been demonstrated in extracts of cat dander and pelt [5,[7][8][9][10][11][12][13][14][15][16], serum [5][6][7]11], urine [6,12,13,15] and saliva [6,[13][14][15]17]. Cat extracts used for diagnosis and specific immunotherapy are generally prepared from hair that has been cut close (approx 1 mm) to the skin surface without severing the tissue, or from pelt that contains a relatively high amount of serum proteins including albumin.…”