Rat aglycotransferrin and human monoglycotransferrin: Production and metabolic properties

Regoeczi, E.; Bolyos, Maria; Chindemi, Paul A.

doi:10.1016/0003-9861(89)90331-7

Cited by 11 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence or absence of carbohydrate has no impact on the binding of iron to Tf or the binding of Tf to the TfR [345]. Removal of one or more of the four terminal sialic acids from the two biantenary glycans of Tf may target them for removal from the circulation by liver asialoreceptors [346]. …”

Section: A Brief History Of Human Serum Transferrinmentioning

confidence: 99%

The long history of iron in the Universe and in health and disease

Sheftel

Mason

Ponka

2012

Biochimica et Biophysica Acta (BBA) - General Subjects

189

155

View full text Add to dashboard Cite

Background Not long after the Big Bang, iron began to play a central role in the Universe and soon became mired in the tangle of biochemistry that is the prima essentia of life. Since life’s addiction to iron transcends the oxygenation of the Earth’s atmosphere, living things must be protected from the potentially dangerous mix of iron and oxygen. The human being possesses grams of this potentially toxic transition metal, which is shuttling through his oxygen-rich humor. Since long before the birth of modern medicine, the blood—vibrant red from a massive abundance of hemoglobin iron—has been a focus for health experts. Scope of Review We describe the current understanding of iron metabolism, highlight the many important discoveries that accreted this knowledge, and describe the perils of dysfunctional iron handling. General Significance Isaac Newton famously penned, “If I have seen further than others, it is by standing upon the shoulders of giants”. We hope that this review will inspire future scientists to develop intellectual pursuits by understanding the research and ideas from many remarkable thinkers of the past. Major Conclusions The history of iron research is a long, rich story with early beginnings, and is far from being finished.

show abstract

Section: A Brief History Of Human Serum Transferrinmentioning

confidence: 99%

The long history of iron in the Universe and in health and disease

Sheftel

Mason

Ponka

2012

Biochimica et Biophysica Acta (BBA) - General Subjects

189

155

View full text Add to dashboard Cite

show abstract

“…Native hTF is a glycoprotein with two N-linked biantennary glycans in the C-lobe (at residues Asn413 and Asn611). While glycosylation appears to have no effect on TFR binding or iron uptake or release by hTF (Mason et al, 1993), it has been suggested that loss of the terminal sialic acids over time may play a role in clearance of hTF from the blood by asialo receptors in the liver (Regoeczi, Bolyos, & Chindemi, 1989). …”

Section: Transferrinmentioning

confidence: 99%

Transferrin-Mediated Cellular Iron Delivery

Luck

Mason

2012

Current Topics in Membranes

132

116

View full text Add to dashboard Cite

Essential to iron homeostasis is the transport of iron by the bilobal protein human serum transferrin (hTF). Each lobe (N- and C-lobe) of hTF forms a deep cleft which binds a single Fe3+. Iron-bearing hTF in the blood binds tightly to the specific transferrin receptor (TFR), a homodimeric transmembrane protein. After undergoing endocytosis, acidification of the endosome initiates the release of Fe3+ from hTF in a TFR-mediated process. Iron-free hTF remains tightly bound to the TFR at acidic pH; following recycling back to the cell surface, it is released to sequester more iron. Efficient delivery of iron is critically dependent on hTF/TFR interactions. Therefore, identification of the pH-specific contacts between hTF and the TFR is crucial. Recombinant protein production has enabled deconvolution of this complex system. The studies reviewed herein support a model in which pH-induced interrelated events control receptor-stimulated iron release from each lobe of hTF.

show abstract

“…Glycosylation can regulate the lifespan of proteins. In vivo experiments in rats have shown that the half-life of Tf proteins without sugar chains is significantly lower than that of Tf proteins containing complex glycans [ 65 ], that is, less glycosylated proteins are degraded from the cell relatively quickly. This means that the TfC2 protein in AD cells can be removed more quickly, which is beneficial to the cells.…”

Section: Introductionmentioning

confidence: 99%

New insight into protein glycosylation in the development of Alzheimer’s disease

Zhao,

Lang

2023

Cell Death Discov.

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a chronic neurodegenerative disease that seriously endangers the physical and mental health of patients, however, there are still no effective drugs or methods to cure this disease up to now. Protein glycosylation is the most common modifications of the translated proteins in eukaryotic cells. Recently many researches disclosed that aberrant glycosylation happens in some important AD-related proteins, such as APP, Tau, Reelin and CRMP-2, etc, suggesting a close link between abnormal protein glycosylation and AD. Because of its complexity and diversity, glycosylation is thus considered a completely new entry point for understanding the precise cause of AD. This review comprehensively summarized the currently discovered changes in protein glycosylation patterns in AD, and especially introduced the latest progress on the mechanism of protein glycosylation affecting the progression of AD and the potential application of protein glycosylation in AD detection and treatment, thereby providing a wide range of opportunities for uncovering the pathogenesis of AD and promoting the translation of glycosylation research into future clinical applications.

show abstract

Rat aglycotransferrin and human monoglycotransferrin: Production and metabolic properties

Cited by 11 publications

References 22 publications

The long history of iron in the Universe and in health and disease

The long history of iron in the Universe and in health and disease

Transferrin-Mediated Cellular Iron Delivery

New insight into protein glycosylation in the development of Alzheimer’s disease

Contact Info

Product

Resources

About