Rat-bite Fever Due to Streptobacillus moniliformis

McGill, R. C.; Martín, Antonio Manuel; Edmunds, P. N.

doi:10.1136/bmj.1.5497.1213

Cited by 21 publications

(6 citation statements)

References 4 publications

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“…Other antibiotics used for the treatment of streptobacillary RBF in humans are ampicillin (Mandel 1985, Kunnert et al 1985, streptomycin (McGill et al 1966), tetracycline (Holden & McKay 1964), chloramphenicol (Hamburger & Knowles 1953), gentamicin (Rumley et al 1987j, cefuroxime (Clausen 1987), vancomycin (Fordham et 01. 1992) and erythromycin (Konstantopoulos et al 1992).…”

Section: Antibiotic Susceptibility and Antimicrobial Therapymentioning

confidence: 99%

Streptobacillus moniliformis-a zoonotic pathogen. Taxonomic considerations, host species, diagnosis, therapy, geographical distribution

Wúllenweber¹

1995

Lab Anim

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Streptobacillus moniliformis (Sm), the causative agent of rat-bite fever and Haverhill fever in man, is also a pathogen in certain laboratory and domestic animals. With the introduction of modern maintenance systems, this microorganism seemed to be eradicated from laboratory animal units, but recent reports of Streptobacillus moniliformis (Sm) in colonies of laboratory rodents give evidence that this 'forgotten' bacterium can still be found even behind hygienic barrier systems. Although various national and international recommendations on microbiological screening include Sm, attempts to screen might fail because of insufficient knowledge about this remarkable bacterium. This article highlights these problems. As there is no recent review of Streptobacillus moniliformis, present knowledge of this zoonotic agent is summarized to include: description of the bacterium, its taxonomic position, host spectrum and clinical importance for animals and man, cultivation, diagnosis, antibiotic therapy, risk to laboratory personnel (occupational hazard) and geographical distribution.

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Section: Antibiotic Susceptibility and Antimicrobial Therapymentioning

confidence: 99%

Streptobacillus moniliformis-a zoonotic pathogen. Taxonomic considerations, host species, diagnosis, therapy, geographical distribution

Wúllenweber¹

1995

Lab Anim

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“…Fever is present in either form. Inflammation associated with the bite and lymphadenopathy are frequently accompanied by headache, general malaise, myalgia, and chills (Arkless 1970;Cole et al 1969;Gilbert et al 1971;McGill et al 1966). The discrete macular rash that often appears on the extremities may generalize into pustular or petechial sequelae.…”

Section: Mode Of Transmissionmentioning

confidence: 99%

Zoonoses and Other Human Health Hazards

Newcomer¹,

Fox²

2007

The Mouse in Biomedical Research

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“…Several writers (Brown & Nunemaker, 1942;McGill, Martin & Edmunds, 1966) state that some permanent limitation of movement may occur in affected joints.…”

Section: Essentials Of the Human Diseasementioning

confidence: 99%

“…In two recent cases in Britain, biochemical evidence of liver dysfunction was observed (McGill et al, 1966). Although the disease is checked by penicillin therapy, penicilIin usualIy fails to effect a complete cure (Holden & MacKay, 1964).…”

Section: Essentials Of the Human Diseasementioning

confidence: 99%

“…Although the disease is checked by penicillin therapy, penicilIin usualIy fails to effect a complete cure (Holden & MacKay, 1964). However, combined antibiotic therapy seems to be successful; two cases treated with penicillin and streptomycin (McGill et al, 1966) and one case treated with tetracycline followed by penicillin were cured (Holden & MacKay, 1964). The case at Mill Hill was also cured by streptomycin-penicillin therapy, although a relapse may have occurred six to eight months after apparent recovery.…”

Section: Essentials Of the Human Diseasementioning

confidence: 99%

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Rat-Bite Fever in Laboratory Personnel

Gledhill

1967

Lab Anim

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SUMMARYA few cases of rat-bite fever due to Streptobacillus moniliformis have been reported in laboratory workers. Since many laboratory rats carry the aetiological agent in the upper respiratory tract, the opportunity for human infections is high, and undiagnosed infections are probably commoner than is supposed. The symptoms and means of diagnosis of human cases are described, together with a brief account of the infection in laboratory animals. The human disease is also compared with rat-bite fever due to Spirillum minus, which on current evidence appears to be rarer than that due to Streptobacillus moniliformis.

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Rat-bite Fever Due to Streptobacillus moniliformis

Cited by 21 publications

References 4 publications

Streptobacillus moniliformis-a zoonotic pathogen. Taxonomic considerations, host species, diagnosis, therapy, geographical distribution

Streptobacillus moniliformis-a zoonotic pathogen. Taxonomic considerations, host species, diagnosis, therapy, geographical distribution

Zoonoses and Other Human Health Hazards

Rat-Bite Fever in Laboratory Personnel

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