Rat Colonic Carcinogenesis After Ureterosigmoidostomy: Pathogenesis and Immunohistological Study

Daher, N.; Gautier, Rodolphe; Abourachid, H; Decaëns, C.; Bara, Jacques

doi:10.1016/s0022-5347(17)42913-2

Cited by 28 publications

(7 citation statements)

References 22 publications

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“…The presence of dysplasia is expected after vesico-colonic anastomosis in rats (2,16). In our investigation the presence of dysplasia was not significantly different from the controls, which could possibly be attributed to the timing of the experiment.…”

Section: Commentscontrasting

confidence: 46%

Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site

et al. 2006

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Objective: The incorporation of bowel segments for urinary tract reconstruction may induce intestinal mucosal changes with the development of metabolic, nutritional, gastrointestinal and carcinogenic complications. The early histological and histochemical changes of the intestinal mucosa in contact with the feces-urine mixture, are evaluated in the present study. Materials and Methods: Twelve rats (operated group) were submitted to a vesico-colonic anastomosis, and 10 rats (control group) underwent a sham operation (the colon was opened and immediately sutured). On the operated group, the left colon was divided into 3 equal portions and the middle segment was used for the bladder-colonic anastomosis. After 20 weeks, the animals were sacrificed and the entire left colon in each group, as well as the bladder and the vesico-colonic anastomosis in the operated group, was removed. The proximal, middle (anastomotic site in the operated group and sutured portion in the control group) and distal colon were used for histological and histochemical studies. Results: Metaplasia, chronic inflammatory process and fibrosis were significantly greater at the anastomotic site compared to the middle segment of the control group. There were no differences in both groups in terms of dysplasia, atrophy and hypertrophy either on the proximal, middle or anastomotic area and distal portion of the left colon. All animals in the operated group showed a reduced presence of sulfomucin and an increase in the sialomucin content. Conclusion:The histological changes observed in this study may suggest a precancerous phenomenon.

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Section: Commentscontrasting

confidence: 46%

Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site

et al. 2006

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“…Vasectomised rats served as a control group. Other authors continued with this model and reported up to 80% of tumours (Gittes, 1986;Daher et al, 1988). Harguindey et al (1976) suggested that irritation produced by the excessive concentration of electrolytes was responsible for carcinogenesis.…”

Section: Discussionmentioning

confidence: 98%

Induction of Carcinoma at Ureterosigmoid Anastomosis–with and without Faecal Stream

Miersch

Vogel

1992

British Journal of Urology

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The induction of tumours at the site of uretero-intestinal anastomosis was investigated in Hannover: WISTAR rats. The rats were divided into 3 groups. In one group (n = 70) the ureter of the left kidney was implanted into the colon, using microsurgical techniques developed for humans. In 13% of the rats in this group benign tumours developed; in 16% malignant tumours occurred. In a second group (n = 76) the ureter was implanted into a rectal bladder; the faeces were excluded from the anastomosis by a descending colon anus praeter. In this group benign tumours developed in 17% and malignant tumours in 8%, all of them being situated at the site of the anastomosis. In a control group (n = 80) no colonic tumour could be identified.

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“…Another theory of carcinogenesis has been suggested involving bacterial activation of endogenously formed N-nitrosamine. [16][17][18][19][20] In this case, it is unclear whether the tumour originated from the skin or the ileum. Given our patient's chronic catheterization, chronic inflammation of the stoma and Monti ileal segment may likely be the predisposing factor for developing squamous metaplasia and SCC in situ.…”

Section: Discussionmentioning

confidence: 99%

First case of invasive squamous cell carcinoma in a stoma of a Monti ileovesicostomy

Reid¹,

Althunayan

Capolicchio³

et al. 2014

CUAJ

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We report a very rare case of invasive squamous cell carcinoma (SCC) in the abdominal stoma of a Monti ileovesicostomy. Our patient underwent an uncomplicated Monti ileovesicostomy at age 16 for a neurogenic bladder. She presented 10 years later with difficulty catheterizing the stoma. A biopsy of peristomal tissue showed moderately differentiated SCC. A cystoscopy did not reveal any bladder tumours or suspicious lesions. A computed tomography (CT) scan of the abdomen and pelvis did not demonstrate metastasis. The patient underwent a complete en bloc resection of the stomal site, the Monti, a partial cuff of bladder, and 2 loops of bowel that were adherent to the Monti. Final pathology revealed pure invasive SCC arising around the stoma and negative surgical margins. Six months later, a follow-up CT scan showed no evidence of malignancy, while a cystoscopy revealed a small erythematous area in the posterior bladder wall. Urinary cytology was positive for SCC. Transurethral resection of the erythematous lesion with random bladder biopsies showed SCC in situ in the erythematous lesion and right lateral bladder wall. Staging workup was negative. The patient subsequently underwent a radical cystectomy and ileal conduit diversion with bilateral pelvic lymph node dissection. Final pathology on cystectomy specimen was SCC in situ without evidence of invasive carcinoma. The patient has remained in remission at the 3-year follow-up.

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Rat Colonic Carcinogenesis After Ureterosigmoidostomy: Pathogenesis and Immunohistological Study

Cited by 28 publications

References 22 publications

Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site

Histological and histochemical changes of the intestinal mucosa at the urothelial-enteric anastomotic site

Induction of Carcinoma at Ureterosigmoid Anastomosis–with and without Faecal Stream

First case of invasive squamous cell carcinoma in a stoma of a Monti ileovesicostomy

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