Rat serum lipoproteins during carcinogenesis of the liver in the preneoplastic and the neoplastic state

Narayan, K A

doi:10.1002/ijc.2910080109

Cited by 13 publications

(1 citation statement)

References 23 publications

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“…Phenobarbital is also known to increase hepatic VLDL production in rats (Infante et al, 1971). It is reported that serum lipoproteins are increased during liver carcinogenesis in the preneoplastic and neoplastic states and has been pointed out that increased lipoprotein is required for proliferating tissues to synthesize membranes or to supply energy during carcinogenesis (Narayan, 1971). In another study by Prabhakaran et al, dietary intake of 60 mg/kg alpha-HCH by normal diet fed pregnant rats on the 6 th , 10 th and 14 th day of gestation resulted in hypercholesterolemia and hypertriglyceridemia (Prabhakaran and Devi, 1993).…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Gene Expression Profiles in Rat Liver After Administration of Alpha-Hexachlorocyclohexane and Lindane

et al. 2007

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-Alpha-hexachlorocyclohexane (alpha-HCH) is a stereoisomer of gamma-HCH, the active ingredient of lindane (> 99% gamma-HCH). In the present study, cDNA microarray technology was employed to identify changes in gene expression associated with toxicity in livers of male Fischer 344 rats after treatment with alpha-HCH (2, 20 mg/kg/day) and lindane (1, 10 mg/kg/day) by daily oral gavage for up to 28 days. Liver samples were obtained after 1, 3, 7, 14 and 28 days and compared for gene expression profiles. The dose of the alpha-HCH was higher than that of lindane and toxicity was greater, but the numbers of probe sets with differences in expression were fewer for the alpha-HCH-treated group except on Day 3. Only very few probe sets with differences in expression overlapped between alpha-HCH and lindane at each time point and the gene expression profiles were very dissimilar. Important liver-based differences in expression between alpha-HCH and lindane might possibly account for hepato-carcinogenicity of alpha-HCH.

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Section: Discussionmentioning

confidence: 99%

A Comparative Study of Gene Expression Profiles in Rat Liver After Administration of Alpha-Hexachlorocyclohexane and Lindane

et al. 2007

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Carcinoma of the gallbladder. Staging, treatment, and prognosis

Nevin

Moran

Kay

et al. 1976

Cancer

292

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Sixty-six cases of carcinoma of the gallbladder treated at The Memorial Hospital, Danville, Virginia, and the Medical College of Virginia, Richmond, were staged according to depth of invasion and spread and graded histologically; the findings were correlated with survival. Results from the two hospitals were essentially identical and the survival figures correlated well with 399 reported cases in the medical literature which could be staged according to the depth of invasion. A simple method combining staging and histologic grading of cancer of the gallbladder, which can easily be applied to all cancers of the gallbladder removed surgically and which should prove useful in the management of this disease, is described. Essentially all of the carcinomas of the gallbladder in the series were incidental findings at surgery for gall stones which may explain a relatively high proportion of superficial carcinomas which are cured by the removal of the gallbladder.

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Effect of S-Adenosyl-L-Methionine on Serum Lipoprotein in Experimental Hepatic Carcinogenesis

Miro

Arce

Aylagas

et al. 1989

Biochemistry of Chemical Carcinogenesis

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Rat serum lipoproteins during carcinogenesis of the liver in the preneoplastic and the neoplastic state

Cited by 13 publications

References 23 publications

A Comparative Study of Gene Expression Profiles in Rat Liver After Administration of Alpha-Hexachlorocyclohexane and Lindane

A Comparative Study of Gene Expression Profiles in Rat Liver After Administration of Alpha-Hexachlorocyclohexane and Lindane

Carcinoma of the gallbladder. Staging, treatment, and prognosis

Effect of S-Adenosyl-L-Methionine on Serum Lipoprotein in Experimental Hepatic Carcinogenesis

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