Rat urinary metabolites from O, O‐diethyl‐O‐(3, 5, 6‐trichloro‐2‐pyridyl) phosphorothioate

Bakke, J. E.; Feil, V. J.; Price, C. E.

doi:10.1080/03601237609372038

Cited by 53 publications

(33 citation statements)

References 4 publications

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“…Carbaryl is a common carbamate insecticide marketed primarily for use on turf and gardens, while naphthalene is used in mothballs and is found in cigarette smoke and petroleum products (Hill et al, 1995a). TCPY is the major metabolite in urine of the pesticides chlorpyrifos, chlorpyrifos-methyl, and triclopyr and has a biological halflife of approximately 27 h (Bakke et al, 1976;Nolan et al, 1984;Hill et al, 1995a). TCPY is also the principal product of environmental degradation of chlorpyrifos and may persist in soil for more than 1 year (Racke et al, 1992).…”

Section: Methodsmentioning

confidence: 99%

A longitudinal investigation of selected pesticide metabolites in urine

MacIntosh

Needham

Hammerstrom

et al. 1999

J Expo Sci Environ Epidemiol

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As part of a longitudinal investigation of environmental exposures to selected chemical contaminants, concentrations of the pesticide metabolites 1-naphthol (1NAP), 3,5,6-trichloro-2-pyridinol (TCPY), malathion dicarboxylic acid (MDA), and atrazine mercapturate (AM) were measured in repeated samples obtained from 80 individuals in Maryland during 1995±1996. Up to six urine samples were collected from each individual at intervals of approximately 8 weeks over a 1-year period (i.e., one sample per participant in each of six cycles). 1NAP (median=4.2 g/l and 3.3 g/g creatinine) and TCPY (median=5.3 g/l and 4.6. g/g creatinine) were present in over 80% of the samples, while MDA and AM were detected infrequently (6.6% and <1% of samples, respectively). Geometric mean (GM) concentrations of 1NAP in urine did not vary significantly among sampling cycles. In contrast, GM concentrations of TCPY were significantly greater in samples collected during the spring and summer of 1996 than in the preceding fall and winter. Repeated measurements of 1NAP and TCPY from the same individual over time were highly variable. The average range of 1NAP and TCPY concentrations from the same individual were approximately 200% and 50% greater than the respective population mean levels. Geometric mean (GM) TCPY concentrations differed significantly between Caucasian (n=42, GM=5.7 g/g creatinine) and African-American (n=11, GM=4.0 g/g) participants and among education levels, but were not significantly different among groups classified by gender, age, or household income. In future research, environmental measurements of the parent compounds and questionnaire data collected concurrently with the biomarker data will be used to characterize the determinants of variability in the urinary pesticide metabolite levels.

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Section: Methodsmentioning

confidence: 99%

A longitudinal investigation of selected pesticide metabolites in urine

MacIntosh

Needham

Hammerstrom

et al. 1999

J Expo Sci Environ Epidemiol

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“…Thus, an absorption fraction of 1.0 was used in the chlorpyrifos exposure model, with a uniform uncertainty distribution ranging from 0.8 to 1.0 (Table 17) . Nolan et al (1984) reported that in a study on humans, 70% of an ingested dose of chlorpyrifos was absorbed in 48 h. Bakke et al ( 1976) , Ahadaya et al ( 1981) , and Smith et al (1967) found that 90% of an administered dose of in an acute oral exposure was absorbed in rats. Thus, a constant absorption value of 0.7 was used for all simulated individuals and ingested media in the chlorpyrifos exposure model (assumes that the variation between individuals in the population is small) , with a uniform uncertainty distribution ranging from 0.5 to 0.9 (Table 17) .…”

Section: Absorption Factorsmentioning

confidence: 99%

Modeled estimates of chlorpyrifos exposure and dose for the Minnesota and Arizona NHEXAS populations

Buck

Özkaynak

Xue³

et al. 2001

J Expo Sci Environ Epidemiol

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This paper presents a probabilistic, multimedia, multipathway exposure model and assessment for chlorpyrifos developed as part of the National Human Exposure Assessment Survey ( NHEXAS) . The model was constructed using available information prior to completion of the NHEXAS study. It simulates the distribution of daily aggregate and pathway -specific chlorpyrifos absorbed dose in the general population of the State of Arizona ( AZ) and in children aged 3 ± 12 years residing in Minneapolis ± St. Paul, Minnesota ( MSP) . Pathways included were inhalation of indoor and outdoor air, dietary ingestion, non -dietary ingestion of dust and soil, and dermal contact with dust and soil. Probability distributions for model input parameters were derived from the available literature, and input values were chosen to represent chlorpyrifos concentrations and demographics in AZ and MSP to the extent possible. When the NHEXAS AZ and MSP data become available, they can be compared to the distributions derived in this and other prototype modeling assessments to test the adequacy of this pre -NHEXAS model assessment. Although pathway -specific absorbed dose estimates differed between AZ and MSP due to differences in model inputs between simulated adults and children, the aggregate model results and general findings for simulated AZ and MSP populations were similar. The major route of chlorpyrifos intake was food ingestion, followed by indoor air inhalation. Two -stage Monte Carlo simulation was used to derive estimates of both interindividual variability and uncertainty in the estimated distributions. The variability in the model results reflects the difference in activity patterns, exposure factors, and concentrations contacted by individuals during their daily activities. Based on the coefficient of variation, indoor air inhalation and dust ingestion were most variable relative to the mean, primarily because of variability in concentrations due to use or no -use of pesticides. Uncertainty analyses indicated a factor of 10 ± 30 for uncertainty of model predictions of 10th, 50th, and 90th percentiles. The greatest source of uncertainty in the model stems from the definition of no household pesticide use as no use in the past year. Because chlorpyrifos persists in the residential environment for longer than a year, the modeled estimates are likely to be low. More information on pesticide usage and environmental concentrations measured at different post -application times is needed to refine and evaluate this and other pesticide exposure models.

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“…Studies in rats indicate that 90% of a single dose of radioactively labeled chlorpyrifos can be recovered from the urine within a day (Bakke et al, 1976;Smith et al, 1966). The major metabolites were identified as 3,5,6-trichloro-2-pyridinal phosphate (75 to 80%), TCP (15 to 29%), and traces of O,O-diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothioate.…”

Section: Adipose Tissuesmentioning

confidence: 98%