Rate and Amplification of Drug Resistance among Previously‐Treated Patients with Tuberculosis in Kampala, Uganda

Temple, Beth; Ayakaka, Irene; Ogwang, Sam; Nabanjja, Helen; Kayes, Susan; Nakubulwa, Susan; Worodria, William; Levin, Jonathan; Joloba, Moses; Okwera, Alphonse; Eisenach, Kathleen D.; McNerney, Ruth; Elliott, Alison M.; Smith, P. G.; Mugerwa, Roy D.; Ellner, Jerrold J.; Jones-López, Edward C.

doi:10.1086/592252

Cited by 64 publications

(81 citation statements)

References 21 publications

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“…Similar to our study, Temple et al 2008, had shown that 28.1% of M. tuberculosis isolates were resistant to at least one anti-TB drug and 71.9% isolates were sensitive to all four drugs. 16 Among 31 resistant isolates, 11 (35.5%) were mono resistant and 20 (64.5%) were poly resistant. Combined drug resistant was more prevalent in relapse cases visiting NTC.…”

Section: Discussionsupporting

confidence: 90%

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Anti-tubercular drug resistance and predictors of relapse pulmonary tuberculosis, Nepal

Timilshina¹,

Lamsal²,

Dahal³

et al. 2014

Int Jour of Biomed Res

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Section: Discussionsupporting

confidence: 90%

“…The relapse PTB was 45.5% which was less than study reported earlier (57%). 16 In this study, relapse was higher in males (n=89, 70%) than female (n=38, 29.9%). Higher cases of relapse were also seen in a study done by Soomro and Quazi, 2009 which reported that 62% were males and 38% were females.…”

Section: Discussionmentioning

confidence: 46%

Anti-tubercular drug resistance and predictors of relapse pulmonary tuberculosis, Nepal

Timilshina¹,

Lamsal²,

Dahal³

et al. 2014

Int Jour of Biomed Res

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“…If so, this could explain the fact that the rates of resistance to any drug and multidrug resistance were higher in our study. In the literature, the reported rates of normal chest X-rays in patients with smear-or culture-positive PTB are low, (4,11,13,22,24) except in HIV-infected patients. (8) A prevalence survey conducted in Cape Town, South Africa revealed that the presence of any abnormalities on chest X-ray has a high sensitivity for detecting subjects with smear-or culture-positive tuberculosis (0.97%; 95% CI: 0.90-1.00).…”

Section: Discussionmentioning

confidence: 96%

“…(6,13,(19)(20)(21)(22) However, the mean ages reported for PTB patients treated at However, the number of cases of re-treatment was more than twice as high among the patients with bilateral involvement. After the first month of treatment, the proportion of patients with positive cultures was significantly greater in antituberculosis treatment was self-reported in our study, the rates of relapse (12.1%) and re-treatment (12.3%) might represent underestimations.…”

Section: Discussionmentioning

confidence: 99%

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Radiografia torácica e bacteriologia na fase inicial de tratamento de 800 pacientes masculinos com tuberculose pulmonar

et al. 2011

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Objective: To evaluate chest X-rays of patients with pulmonary tuberculosis and to determine whether the extent of radiographic lesions correlates with bacteriological parameters. Methods: In this retrospective, descriptive study, we evaluated chest X-rays, as well as AFB detection by smear microscopy and culture for Mycobacterium tuberculosis, initially and during the first two months of treatment, in 800 male patients hospitalized between 1995 and the present at a 250-bed hospital in northwestern Turkey. Results: The initial mean ESR was 58 ± 37 mm/h. Initial sputum smears and cultures were positive in 83.8% and 89.5% of the patients, respectively. After the first month of treatment, the proportion of patients with positive sputum culture was higher among those with cavitary tuberculosis than among those with non-cavitary tuberculosis (53.7% vs. 37.7%, p < 0.001). The number of affected zones was not correlated with age, symptom duration, contact with an active tuberculosis patient, or concomitant diabetes (p > 0.05 for all) but was positively correlated with the ESR (r = 0.23, p < 0.001). During the first and second months of treatment, conversion to smear-negative status was less common in patients with bilateral involvement than in those with unilateral involvement (p < 0.001 and p = 0.002 for months 1 and 2, respectively). Disease extent did not correlate with age, symptom duration, contact with an active tuberculosis patient, or concomitant diabetes but did correlate with delayed bacteriological recovery. Conclusions: Chest X-ray and bacteriology are valuable tools for the evaluation of pulmonary tuberculosis.Keywords: Radiography, thoracic; Bacteriology; Tuberculosis, pulmonary/drug therapy. ResumoObjetivo: Avaliar radiografias de tórax de pacientes com tuberculose pulmonar e determinar se a extensão das lesões radiográficas correlaciona-se com os parâmetros bacteriológicos. Métodos: Neste estudo descritivo e retrospectivo; foram avaliadas radiografias de tórax, baciloscopias para BAAR e culturas de escarro para Mycobacterium tuberculosis no momento basal e durante os dois primeiros meses de tratamento. A amostra foi composta por 800 pacientes masculinos internados entre 1995 até o presente em um hospital com 250 leitos no noroeste da Turquia. Resultados: A VHS média inicial foi de 58 ± 37 mm/h. Inicialmente, a baciloscopia e as culturas de escarro tiveram resultado positivo em 83,8% e em 89,5% dos pacientes, respectivamente. Após o primeiro mês do tratamento, a proporção de culturas positivas foi maior nos pacientes com doença cavitária do que naqueles sem doença cavitária (53,7% vs. 37,7%; p < 0,001). Não houve correlação do número de zonas afetadas com idade, duração de sintomas, contato com paciente com tuberculose ativa, diabetes concomitante (p > 0.05 para todos), mas houve correlação positiva com VHS (r = 0,23, p < 0,001). Durante o primeiro e o segundo mês de tratamento, a negativação da baciloscopia foi menos frequente nos pacientes com comprometimento bilateral do que naqueles com compr...

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Tuberculosis and Atypical Mycobacterial Infections

Jones-López¹,

Ellner²

2011

Tropical Infectious Diseases: Principles, Pathogens and Practice

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Rate and Amplification of Drug Resistance among Previously‐Treated Patients with Tuberculosis in Kampala, Uganda

Abstract: The burden of drug resistance in previously treated patients with TB in Uganda is sizeable, and the risk of generating additional drug resistance is significant. There is an urgent need to improve the treatment for such patients in low-income countries.

Cited by 64 publications

References 21 publications

Anti-tubercular drug resistance and predictors of relapse pulmonary tuberculosis, Nepal

Anti-tubercular drug resistance and predictors of relapse pulmonary tuberculosis, Nepal

Radiografia torácica e bacteriologia na fase inicial de tratamento de 800 pacientes masculinos com tuberculose pulmonar

Tuberculosis and Atypical Mycobacterial Infections

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