Rate and Equilibrium Data for Substitution Reactions of [Pd( dien )Cl] + with L -Cysteine and Glutathione in Aqueous Solution

Bugarčić, Živadin D.; Jančić, Dejan; Shoukry, Azza A.; Shoukry, Mohamed M.

doi:10.1007/s00706-003-0091-4

Cited by 34 publications

(7 citation statements)

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“…Building on this experience, and in an effort to extend our previous work on the substitution behaviour of [Pd(en)(cbdca)], [Pd(bpy)(cbdca)], 22 where en= ethane-1,2-diamine, bpy = 2,2-bipyridine and cbdca is cyclobutane 1,1-dicarboxylic acid, and our work on the interaction of [Pd(dien)Cl] + where dien is diethylenetriamine or 1,5-diamino-3-azapentane, with L-cysteine and glutathione, 23 we investigate here the substitution behaviour and associated kinetics of [Pd(Pip)Cl(H 2 O)] + with tu, and L-Met using UV-Vis spectrophotometric and stopped-flow techniques. The investigation is performed as a function of nucleophile concentration and temperature which is important for the general development of new active complexes for cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Kinetics and mechanism for the substitution reactions of monoaquamonochloro-(piperazine) palladium (II) complex with L-methionine and thiourea in aqueous solution

Shoukry

2013

J Chem Sci

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The interaction of the palladium(II) complex [Pd(Pip)Cl(H 2 O)] + , where Pip is piperazine, with the sulphur donor nucleophiles; L-methionine (L-Met), and thiourea (tu) was studied under pseudo-first-order conditions as a function of nucleophile concentration and temperature, using UV-Visible spectrophotometric and stopped-flow techniques. Two consecutive reaction steps were observed for the substitution process with L-methionine. For the substitution with thiourea, a third reaction step, the displacement of the labilized amine, as a result of the strong trans-effect of thiourea ligand was observed. 1 HNMR spectroscopy was used to follow the substitution of the ligand by thiourea. The activation parameters for all reactions studied suggest an associative substitution mechanism.

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Section: Introductionmentioning

confidence: 99%

Kinetics and mechanism for the substitution reactions of monoaquamonochloro-(piperazine) palladium (II) complex with L-methionine and thiourea in aqueous solution

Shoukry

2013

J Chem Sci

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“…cisplatin, carboplatin and oxaliplatin) used as reference, and show fewer side effects relative to other heavy metal anticancer compounds [4]. Recent work in our laboratories focused on equilibria of complex formation reactions of cis-(diamine)palladium(II) complexes with DNA, the major target in chemotherapy of tumors, and amino acids, peptides, and dicarboxylic acids and esters [5][6][7][8][9][10]. In this project, complex formation equilibria between [Pd(Phenpip)(H 2 O) 2 ] 2+ (structure 1) and some selected bio-relevant ligands are investigated.…”

Section: Introductionmentioning

confidence: 99%

Complex formation reactions and equilibrium studies of mixed ligand complexes of diaqua (1-Phenyl piperazine)(Palladium)(II) with some biologically relevant ligands.

Shoukry

2012

International Journal of Basic and Applied Sciences

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With the purpose of the search of new antitumor metal complexes, the complex-formation reactions of2+ (Phenpip = 1-Phenylpiperazine) with some selected bio-relevant ligands, containing different functional groups (amino acids, peptides, DNA constituents and dicarboxylic acids) were investigated. Stoichiometry and stability constants for the complexes formed are reported. The results show the formation of 1 : 1 complexes with amino acids and dicarboxylic acids. The effect of chelate ring size of the dicarboxylic acid complexes on their stability constants was examined. Peptides form both 1 : 1 complexes and the corresponding deprotonated amide species. Structural effects of the peptide on the amide deprotonation were investigated. DNA pyrimidinic constituents, such as uracil, uridine, thymidine and thymine, form 1 : 1 and 1 : 2 complexes, whereas purinic constituents, such as inosine, inosine 5´-monophosphate (5-IMP) form only 1 : 1 complexes. The stability constant of the complexes formed in solution were determined and the binding centers of the ligands were assigned. The concentration distribution diagrams of the complexes were evaluated

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“…In conjunction with our research program [15][16][17][18][19][20][21][22][23] directed to the study of the metal complexes of biological significance, the present investigation presents the results of potentiometric studies of the formation of binary and ternary complexes involving Cd II , NTP and some selected bio-relevant ligands. NTP was chosen as it forms a highly stable 1:1 complex with Cd II in aqueous solution and has a coordination sites that resemble those of nucleotides.…”

Section: Introductionmentioning

confidence: 99%

Potentiometric Studies of Binary and Ternary Complexes Involving Cadmium(II) and Nitrilo‐Tris(Methyl Phosphonic Acid) with Amino Acids, peptides and DNA Constituents

Shoukry¹,

Shoukry²

2007

Annali di Chimica

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The complexing properties of nitrilo-tris(methylphosphonic acid) (NTP) with cadmium(II) were investigated pH-metrically at 25 degrees C and at ionic strength of 0.1 mol dm(-3) (NaNO3). Stoichiometry and stability constants for the complexes formed are reported. Cadmium (II) forms Cd(NTP)(4-) and the corresponding hydroxy complexes. The ternary complexes are formed in a stepwise mechanism whereby NTP binds to cadmium(II), followed by coordination of amino acids, peptides or DNA. The concentration distribution of the various complex species has been evaluated.

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Rate and Equilibrium Data for Substitution Reactions of [Pd( dien )Cl] + with L -Cysteine and Glutathione in Aqueous Solution

Cited by 34 publications

References 2 publications

Kinetics and mechanism for the substitution reactions of monoaquamonochloro-(piperazine) palladium (II) complex with L-methionine and thiourea in aqueous solution

Kinetics and mechanism for the substitution reactions of monoaquamonochloro-(piperazine) palladium (II) complex with L-methionine and thiourea in aqueous solution

Complex formation reactions and equilibrium studies of mixed ligand complexes of diaqua (1-Phenyl piperazine)(Palladium)(II) with some biologically relevant ligands.

Potentiometric Studies of Binary and Ternary Complexes Involving Cadmium(II) and Nitrilo‐Tris(Methyl Phosphonic Acid) with Amino Acids, peptides and DNA Constituents

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