Ultra-high ductile concrete (UHDC) is known for ultra-high tensile ductility, and ultra-high performance concrete (UHPC) has ultra-high compressive strength. Reinforced UHDC-UHPC panels that are made of UHDC and UHPC (i.e., hybrid panels) are expected to have excellent blast-resistance capacity.However, only limited research is devoted to study the dynamic performance of the panels under explosion. To further investigate the dynamic performance of such kind of composite structural system, numerical simulations are carried out through LS-DYNA. The developed material models are used for describing the mechanical properties of UHDC, UHPC and steel bars at high strain rate.Based on the corresponding field blast test results, the feasibility and accuracy of the adopted finite element models are validated. Furthermore, parameter analysis is applied for investigating the effects of scale distance, reinforcement ratio and concrete type on the dynamic performance. It is concluded that the maximum deflection of reinforced UHDC-UHPC panels reduces with increasing scale distance and reinforcement ratio. Reinforced UHDC-UHPC panels possess excellent blast-resistance capacity in comparison with reinforced concrete panels.