Rate-dependent mechanical properties of dry blended pharmaceutical powder formulations for tabletting applications

Feasibility of Relationships between Tablet Physical Quality Parameters and Mechanical Properties of Dry Powder Formulation

“…The proportion of other four ingredients were maintained at the same level, i.e., Avicel: Acetaminophen: Ac-Di-Sol: Magnesium stearate :0.90:0.05:0.03:0.02 (Table 2). Detailed description of all the ingredients used and selection of binder levels are presented in Pandeya (2005) and Puri (2008 and2011). The drug loading in pharmaceutical formulations varies over the entire spectrum of values (i.e., from 0.1% to 100%) depending upon the type of drug and its application.…”

“…The tests were conducted to produce stress difference of 1 and 2 MPa, which ensured stresses below but in the vicinity of incipient failure of powder specimen. Rationale for selection of these values is discussed in detail (Pandeya, 2009;Pandeya and Puri, 2011).…”

“…These parameters were determined at loading rates of 10 and 20 MPa/min at 0, 5, and 10% binder content. The detailed powder fundamental properties are given in Pandeya and Puri (2011). For completeness; herein, a summar y of powder proper ties: Bulk modulus, Compression index, Spring-back index, and Shear modulus, is presented in the following paragraphs.…”

“…For completeness; herein, a summar y of powder proper ties: Bulk modulus, Compression index, Spring-back index, and Shear modulus, is presented in the following paragraphs. Rationale for the trends of these properties and corresponding discussion are given in Pandeya and Puri (2011).…”

“…Toward that end, fundamental mechanical properties of powder formulations were determined using a flexible membrane cubical triaxial tester (CTT). Some of these test results have been presented in Pandeya and Puri (2011) and comprehensive results are given in Pandeya (2009). In addition, quality parameters of the tablets formed from the same powder formulations were determined.…”