Rate of decline of cefotaxime and ceftazidime in milk following intramammary administration to healthy and mastitic dairy cows

Rule, Roberto; Quiroga, Germán; Buschiazzo, H.; Lacchini, Raúl; Mordujovich, Perla

doi:10.1136/vr.143.11.310

Cited by 6 publications

(6 citation statements)

References 22 publications

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“…The effect of mastitis on drug elimination is a somewhat controversial subject. Higher concentrations of cefotaxime were found in milk of mastitic quarters but no difference was seen in the elimination of ceftazidime (Rule et al 1998), or higher concentrations occurred for polymyxin B in healthy quarters (Malvisi et al 1991).…”

Section: Introductionmentioning

confidence: 95%

Elimination of erythromycin in milk after intramammary administration in cows with specific mastitis: relation to dose, milking frequency and udder health

Bansal

Bajwa

Randhawa

et al. 2010

Trop Anim Health Prod

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Elimination of erythromycin in milk following intramammary therapy of specific mastitis in cows was studied. Five cows received therapy in one quarter (G1), and eight in two quarters with five milked twice (G2) and three thrice a day (G3). Dose infused was 300 mg/quarter 12 h × 5 times. The drug concentrations in milk were determined using microbial assay technique with Micrococcus luteus as the test organism. Considerable variations occurred in the excretion of drug; levels for treated quarters being 8.25 to 37.61 μg/ml at first milking that declined rapidly at 24 h and no drug activity was observed beyond 36 h post treatment. In total, about 6-25% of the last infused dose appeared in the milk. Drug crossed to 1/15 quarter (G1), 6/10 quarters (G2) and all the six untreated quarters (G3). Crossover levels were significantly higher in mastitic quarters and for G3 cows, but duration of excretion remained same in all cases. It seems that crossover of erythromycin to untreated quarters is related to the udder health and dose infused.

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Section: Introductionmentioning

confidence: 95%

Elimination of erythromycin in milk after intramammary administration in cows with specific mastitis: relation to dose, milking frequency and udder health

Bansal

Bajwa

Randhawa

et al. 2010

Trop Anim Health Prod

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“…The values for ceftazidime concentrations in milk over time at 1 h and 12 h post-administration of the 1st dose of antibiotics in healthy and mastitic cows were high (1028.2 ± 723.1 and 30.5 ± 25.7 and 966.8 ± 278.0 and 131.3 ± 34.9 µg/m , respectively). The authors observed that ceftazidime administered by intramammary infusion to healthy and mastitic cows was distributed from treated to untreated quarters and the t1/2 and rate constant in milk were similar 17 . The drug had good distribution from treated to untreated quarters and the presence of residues was observed, so that milk destined for human consumption had to be discarded for at least 72 h 17 .…”

Section: Introductionmentioning

confidence: 96%

“…The authors observed that ceftazidime administered by intramammary infusion to healthy and mastitic cows was distributed from treated to untreated quarters and the t1/2 and rate constant in milk were similar 17 . The drug had good distribution from treated to untreated quarters and the presence of residues was observed, so that milk destined for human consumption had to be discarded for at least 72 h 17 . It has been observed that low protein binding resulted in ceftazidime penetration into the mammary gland.…”

Section: Introductionmentioning

confidence: 96%

“…Ceftazidime was used to treat dairy cows with clinical signs of inflammation in 1 mammary gland quarter and presence of 1 or more pathogenic microorganisms in that quarter (3 intramammary doses of 200 mg/quarter/12 h) 17 . Thirty dairy cows in full milk production were studied; 10 cows were healthy and microbiologically negative and the other 20 cows had mastitis.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats

Rule

Villagra

Barrena³

et al. 2011

J. S. Afr. Vet. Assoc.

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The aim of this work was to determine the pharmacokinetics of intravenous (iv) and intramuscular (im) ceftazidime administered to lactating (LTG; n = 6) and non-lactating (NLTG; n=6) healthy Creole goats in 2 trials (T1 and T2). During T1 and T2, goats randomly received a single dose of im or iv ceftazidime (10 mg/kg). Serum concentration of iv ceftazidime in NLTG and LTG goats is best described by 2 and 3 compartment models, respectively. The pharmacokinetic parameters of iv and im ceftazidime administered to LTG and NLTG showed statistically significant differences (P<0.05) in the constants (λz, T1 vs T2 [iv] 0.5±0.1 vs 0.3±0.1 /h; T1 vs T2 [im] 0.5±0.2 vs 0.3±0.1 /h) and in the mean times (t1/2, T 1 vs T 2 [iv] 1.6±0.3 vs 2.3±0.6 h; T 1 vs T 2 [im] 1.6±0.7 vs 2.6±0.9 h) of elimination. The bioavailability of ceftazidime in LTG and NLTG was 113.0 ± 17.8 and 96.0 ± 18.0 %, respectively. Ceftazidime concentration in milk at 2 h was: iv = 1.9 ± 0.2 and im = 2.4 ± 0.5 μg/m ; the penetration in milk was iv = 18.3 ± 13.5 and im = 14.3 ± 10.6 %. Ninety-six hours after iv and im administration, residues of the drug were not found in milk. In conclusion, ceftazidime, when administered to goats, showed high concentration times in serum, good penetration into milk and a bioavailability that makes it suitable to be used by the im route

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“…β-lactam antibiotics such as ceftiofur, a third-generation cephalosporin, are often used in dairy cattle for the treatment of mastitis or dry cow therapy ( Hallberg et al, 2006 ; Campos et al, 2021 ). When cephalosporins are applied intramammarily, they are mainly excreted through the urine and udder ( Wilson and Gilbert, 1986 ; Rule et al, 1998 ; Ray et al, 2014 ). Yet, ∼13% of the IMM-administered ceftiofur dose in lactating cows, which includes two doses of 125 mg per quarter given 12 h apart, is detectable in the feces 5–6 days post-treatment ( European Agency for the Evaluation of Medicinal Products, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Untargeted metabolomics and metagenomics reveal signatures for intramammary ceftiofur treatment and lactation stage in the cattle hindgut

Vasco,

Hansen,

Schilmiller

et al. 2024

Front. Mol. Biosci.

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The gut microbiota in cattle is essential for protein, energy, and vitamin production and hence, microbiota perturbations can affect cattle performance. This study evaluated the effect of intramammary (IMM) ceftiofur treatment and lactation stage on the functional gut microbiome and metabolome. Forty dairy cows were enrolled at dry-off. Half received IMM ceftiofur and a non-antibiotic teat sealant containing bismuth subnitrate (cases), while the other half received the teat sealant (controls). Fecal samples were collected before treatment at dry off, during the dry period (weeks 1 and 5) and the first week after calving (week 9). Shotgun metagenomic sequencing was applied to predict microbial metabolic pathways whereas untargeted metabolomics was used identify polar and nonpolar metabolites. Compared to controls, long-term changes were observed in the cows given ceftiofur, including a lower abundance of microbial pathways linked to energy production, amino acid biosynthesis, and other vital molecules. The metabolome of treated cows had elevated levels of stachyose, phosphatidylethanolamine diacylglycerol (PE-DAG), and inosine a week after the IMM ceftiofur application, indicating alterations in microbial fermentation, lipid metabolism, energy, and cellular signaling. Differences were also observed by sampling, with cows in late lactation having more diverse metabolic pathways and a unique metabolome containing higher levels of histamine and histamine-producing bacteria. These data illustrate how IMM ceftiofur treatment can alter the functionality of the hindgut metabolome and microbiome. Understanding how antibiotics and lactation stages, which are each characterized by unique diets and physiology, impact the function of resident microbes is critical to define normal gut function in dairy cattle.

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Rate of decline of cefotaxime and ceftazidime in milk following intramammary administration to healthy and mastitic dairy cows

Abstract: CEFOTAXIME and ceftazidime are third-generation cephalosporins that are stable to 3-lactamases and have a wide antibacterial spectrum and low toxicity (O'

Cited by 6 publications

References 22 publications

Elimination of erythromycin in milk after intramammary administration in cows with specific mastitis: relation to dose, milking frequency and udder health

Elimination of erythromycin in milk after intramammary administration in cows with specific mastitis: relation to dose, milking frequency and udder health

Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats

Untargeted metabolomics and metagenomics reveal signatures for intramammary ceftiofur treatment and lactation stage in the cattle hindgut

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