Rate of detection of lymph node metastasis is correlated with the depth of submucosal invasion in early stage gastric carcinoma

Yasuda, Kazuhiro; Shiraishi, Norio; Suematsu, Toshihiro; Yamaguchi, Kensei; Adachi, Yosuke; Kitano, Seigo

doi:10.1002/(sici)1097-0142(19990515)85:10<2119::aid-cncr4>3.0.co;2-m

Cited by 160 publications

(108 citation statements)

References 15 publications

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“…It is interesting to note that all five of the m-cancers had only perigastric lymph node involvement, but three of the four sm-cancers had an extra-perigastric lymph node metastasis. This finding strongly agrees with a recent report by Yasuda et al [20], which also suggested the histological possibility of metastasis in a tumor with a diameter of 1 to 2 cm. These findings indicate that an EGC with a diameter of more than 1.0 cm seems to be a risk for lymph node metastasis.…”

Section: Discussionsupporting

confidence: 93%

Significant correlation between micrometastasis in the lymph nodes and reduced expression of E-cadherin in early gastric cancer

et al. 2001

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Section: Discussionsupporting

confidence: 93%

Significant correlation between micrometastasis in the lymph nodes and reduced expression of E-cadherin in early gastric cancer

et al. 2001

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“…An imbalance between proteinases and their inhibitors has been demonstrated to be a key factor in many human diseases, especially tumorigenesis (28). Several laboratories, including ours, have shown that among MMPs, MMP-2 expression is related to gastric cancer invasion and metastasis (25,29,30). The present study demonstrates that denbinobin exerts an inhibitory effect on the invasiveness of SNU-484 cells, which may be associated with down-regulation of both MMP-2 and MMP-9.…”

Section: Discussionsupporting

confidence: 62%

Denbinobin, a phenanthrene from dendrobium nobile, inhibits invasion and induces apoptosis in SNU-484 human gastric cancer cells

Song

Kang²,

Hao³

et al. 2011

Oncol Rep

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Abstract. Dendrobium nobile is widely used as an analgesic, an antipyretic, and a tonic to nourish the stomach in traditional medicine. Mounting evidence suggests an antitumor activity of denbinobin, a major phenanthrene isolated from stems of Dendrobium nobile. The present study aimed to investigate the inhibitory effect of denbinobin on the invasive ability of human cancer cells. The cytotoxicity of denbonobin was examined in several human cancer cell lines including SK-Hep-1 hepatocarcinoma cells, SNU-484 gastric cancer cells, and HeLa cervix cancer cells. Because SNU-484 cells showed the lowest IC 50 value, we examined the effect of denbinobin on the invasive ability of SNU-484 cells. The present study revealed, for the first time, that denbinobin inhibits the invasive phenotype of SNU-484 human gastric cancer cells in a dose-dependent manner. Expressions of matrix metalloproteinase (MMP)-2 and MMP-9 were significantly decreased by denbinobin, suggesting that MMP-2/-9 may be responsible for the antiinvasive activity of denbinobin. We also provide evidence that denbinobin induces apoptosis through down-regulation of Bcl-2 and an up-regulation of Bax. Taken together, this study demonstrates that denbinobin inhibits invasion and induces apoptosis in highly invasive SNU-484 human gastric cancer cells. Given that gastric cancer has been estimated to be one of the most common causes of cancer-related death among Asians and the major cause of death from gastric cancer is the metastatic spread of the disease, our findings may provide useful information regarding the application of denbinobin as a chemopreventive agent that could prevent or alleviate metastatic gastric cancer.

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“…The degree of submucosal invasion is recognized as the most signifi cant risk factor correlating with nodal involvement, while lymphatic invasion and histologic differentiation are also important risk factors for nodal involvement [4,5]. On the other hand, several reports have demonstrated the safety from lymphatic metastasis in a limited subgroup of sm1 gastric cancers [6][7][8][9][10][11]. This has raised the question of whether distal or total gastrectomy with lymph node dissection [12][13][14] is necessary for small, differentiated gastric cancers with a depth of sm1.…”

Section: Discussionmentioning

confidence: 99%

Two rare cases of node-positive differentiated gastric cancer despite their infiltration to sm1, their small size, and lack of lymphatic invasion into the submucosal layer

et al. 2008

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Rate of detection of lymph node metastasis is correlated with the depth of submucosal invasion in early stage gastric carcinoma

Cited by 160 publications

References 15 publications

Significant correlation between micrometastasis in the lymph nodes and reduced expression of E-cadherin in early gastric cancer

Significant correlation between micrometastasis in the lymph nodes and reduced expression of E-cadherin in early gastric cancer

Denbinobin, a phenanthrene from dendrobium nobile, inhibits invasion and induces apoptosis in SNU-484 human gastric cancer cells

Two rare cases of node-positive differentiated gastric cancer despite their infiltration to sm1, their small size, and lack of lymphatic invasion into the submucosal layer

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