Rate of diagnosed seasonal influenza in children with influenza-like illness: A cross-sectional study

Abstract

Introduction Although influenza surveillance systems have been used to monitor influenza epidemics, these systems generally evaluate diagnostic information obtained from medical institutions and they do not include patients who have not been examined. In contrast, community based epidemiological studies target people with influenza-like illness (ILI) that self-reported influenza-like symptoms whether they have medical examinations or not. Because the criteria for influenza surveillance systems and ILI differ, there is a gap between them. The purpose of this study was to clarify this gap using school-based survey data. Methods Questionnaires about both ILI and the influenza diagnosis history during the 2018/19 season were administered to the guardians of 11,684 elementary schoolchildren in a single city in Japan. Based on their responses, a Bayesian model was constructed to estimate the probability of infection, ILI onset, and diagnosis at medical institutions. Results Responses were obtained from guardians of 10,309 children (88.2%). Of these, 3,380 children (32.8%) had experienced ILI, with 2,380 (23.1%) diagnosed as influenza at a medical institution. Bayesian estimation showed that the probability of influenza cases being diagnosed among ILI symptomatic children was 70% (95% credible interval, 69–71%). Of the infected children, 5% were without ILI symptoms, with 11% of these patients diagnosed with influenza. Conclusions This epidemiological study clarified the proportion gap between ILI and influenza diagnosis among schoolchildren. These results may help to establish epidemic control measures and secure sufficient medical resources.

Clinical profile of children with influenza like illness during pre-monsoon at coastal Karaikal, Puducherry, India

“…Boca virus was positive in one school aged child (1%), adeno virus in 5 children (1 preschool and 3 school aged and 2 adolescents - 5.1%) and rhino virus in 1 child (preschool age, 1%). Notably, this is comparable to a pre covid Japanese study by Mitsuo et al which revealed 70.2% of ILI in school aged children in their season of influenza [ 9 ]. The present study also depicts that, 78.5% cases of ILI are due to influenza viruses.…”

“…this is comparable to a pre covid Japanese study by Mitsuo et al which revealed 70.2% of ILI in school aged children in their season of influenza[9]. The present study also depicts that, 78.5% cases of ILI are due to influenza viruses.…”

Preschool-located influenza vaccination and influenza-like illness surveillance: an Italian pilot experience

“…In addition, influenza vaccination was demonstrated to improve school attendance and children wellbeing (18). Children with ILI generally do not seek medical care, and not all ILI affected subjects are included in influenza surveillance systems (19). School-based surveillance can represent a valid option, but medical staff need to be present within the building to record symptoms and collect samples.…”