Rate of formation of tertiary dentin in dogs' teeth in response to lining materials

Cavity lining after excavating caries lesions: Meta-analysis and trial sequential analysis of randomized clinical trials

“…Lining might indeed reduce the numbers of bacteria remaining in the cavity before restoration, whilst different liners have been found to exert significantly different antibacterial effects both clinically (12) and in vitro (13)(14)(15). Several studies, mostly conducted in animals, support the hypothesis that liners are capable of inducing dentinogenesis (16,17), reducing pulpal inflammation and protecting the integrity of the pulp (18,19), again with significant differences between various lining materials. In contrast to this relatively large body of evidence, data regarding clinical outcomes in humans are sparse, with the last reviews on this matter each including only one randomized clinical trial, concluding that evidence to refute or support the use of liners is unavailable (2,20).…”

Tertiary Dentine Frequencies in Extant Great Apes and Fossil Hominins

“…This likely relates to evolving mechanisms to produce new dentine in response to stimuli (Neves and Sharpe, 2018). Further histological studies are needed to support this finding, as this will allow microstructure differences to be compared (Smith et al 1994;Tarim et al 1998;Ivanovic and Santini, 1989;Stanley et al 1983;Carvalho and Lussi, 2017). A potential explanation for the substantially different prevalence of tertiary dentine formation in hominids is evolving dental properties to cope with different diets.…”

“…The microanatomy of tertiary dentine has been researched in both humans and non-human animals. In particular, clinical studies have researched the properties of tertiary dentine formation, usually from an oral health perspective (Cox et al 1992;Smith et al 1994;Tarim et al 1998;Ivanovic and Santini, 1989;Neves and Sharpe, 2018). In addition to darker coloration, tertiary dentine has fewer tubules and is denser in structure than primary dentine (Zuo et al 2018).…”

Antibacterial effects of cavity lining: A systematic review and network meta-analysis

“…As liners are thought to induce the development of reactionary dentin (2,3), reduce post-operative pulpal inflammation (4), or isolate the pulp from chemical irritants like hydroxyethyl methacrylate (5), they are commonly used for pulp protection. However, clinical studies do not necessarily support these arguments, with only few trials evaluating for example the risk of post-operative hypersensitivity or the need for endodontic follow-up treatments in teeth with versus without cavity lining (6)(7)(8).…”