Rate of incidence of hepatocellular carcinoma in patients with compensated viral cirrhosis

Chiaramonte, M.; Stroffolini, Tommaso; Vian, A.; Stazi, Maria A.; Floreani, Annarosa; Lorenzoni, U.; Lobello, S.; Farinati, Fabio; Naccarato, R.

doi:10.1002/(sici)1097-0142(19990515)85:10<2132::aid-cncr6>3.3.co;2-8

Cited by 28 publications

(32 citation statements)

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“…A subsequent longitudinal study confirmed these results. 68 The incidence of HCC (per 100 person years) was 6.4 in dually-infected patients, compared to 2.0 in HBV and 3.7 in HCV monoinfected patients, while the cumulative risk of developing HCC at 10 years was 45% in coinfected patients, compared with 16% and 28% in HBV and HCV monoinfected disease controls. However, a study from Japan suggested that dual infection was rare (2%) in Japanese patients with liver cirrhosis and did not play an important role in the occurrence of HCC.…”

Section: Impact Of Hbv/hcv Coinfection On Development Of Hccmentioning

confidence: 99%

Hepatitis B virus/hepatitis C virus coinfection: Epidemiology, clinical features, viral interactions and treatment

Chu

Lee

2008

J of Gastro and Hepatol

194

176

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Because of the shared modes of transmission, hepatitis B virus (HBV)/hepatitis C virus (HCV) coinfection is not uncommon in highly endemic areas and among subjects with a high risk of parenteral infections. The worldwide prevalence of HBV/HCV coinfection is unknown and might be underestimated with the phenomenon of silent (occult) HBV infection. HCV superinfection in patients with chronic HBV infection was the most common clinical features of coinfection in Asia-Pacific countries. Further, most, but not all, clinical observations suggested that interference between the two viruses was more frequently characterized by an inhibition of HBV replication exerted by HCV. However, longitudinal follow-up studies have demonstrated that the virological patterns in coinfection cases are widely divergent and have dynamic profiles over time. As compared with monoinfected patients, HBV/HCV coinfected persons tend to have more severe liver injury, a higher probability of liver cirrhosis and hepatic decompensation, and a higher incidence of hepatocellular carcinoma. Detailed serological and virological evaluations are required for coinfected patients before initiation of antiviral therapy. Previous studies demonstrated that HBV/HCV coinfected patients responded poorly to interferon (IFN) monotherapy. Currently, for patients with dominant HCV infection and low level HBV viremia (<10 4 IU/ mL), IFN or pegylated IFN plus ribavirin can achieve comparable sustained virus response as expected with HCV monoinfection. However, phenomenon of reciprocal viral interference can happen, and resultant "flare" of hepatitis activity may cause liver function deterioration. For coinfected patients with dually-active HBV/HCV, the optimal regimen for therapy remains unclear although adding oral nucleos(t)ide analogs to pegylated IFN and ribavirin seems a reasonable empiric option.

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Section: Impact Of Hbv/hcv Coinfection On Development Of Hccmentioning

confidence: 99%

Hepatitis B virus/hepatitis C virus coinfection: Epidemiology, clinical features, viral interactions and treatment

Chu

Lee

2008

J of Gastro and Hepatol

194

176

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“…Liver cirrhosis is a well-known disease underlying HCC, 1,24 and the reported incidence of HCC development in patients with cirrhosis ranges 2-6.5% per year. [25][26][27][28][29][30] The incidence of HCC development depends on the geographical area or country, sex and age of the patients, and the etiology and severity of the underlying disease. [24][25][26]31 Early identification of asymptomatic HCC at the stage of compensated cirrhosis enables the consideration of specific treatments such as tumor resection, chemoembolization or local ablative therapy for good survival.…”

Section: Screening For Hccmentioning

confidence: 99%

Undiagnosed cirrhosis occurs frequently in the elderly and requires periodic follow ups and medical treatments

Fujimoto¹,

Sawabe²,

Sasaki³

et al. 2008

Geriatrics Gerontology Int

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“…The incidence of HCCs in cirrhotic patients has been reported to be as high as 4% per year, and it is important to perform screening of HCCs by ultrasonography (US) and by checking the level of serum alpha-fetoprotein (aFP). 22,23 Recently, several reports have recommended the use of CT or magnetic resonance (MR) screening instead of ultrasonography (US), particularly in terms of costeffectiveness, and CT or MR are commonly preferred over US for surveillance in the United States and some other countries. [24][25][26][27] Also, in patients treated with ablation therapy or chemoembolization for HCCs, regular follow-up CT examinations are essential to evaluate therapeutic effectiveness and recurrence.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of esophageal varices on liver computed tomography: Receiver operating characteristic analyses of the performance of radiologists and endoscopists

Kim

Choi

Gwak

et al. 2009

J of Gastro and Hepatol

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Experienced readers have a better ability to detect esophageal varices on liver MDCT, but had no higher performance to evaluate high-risk esophageal varices. As the accuracy of detecting high-risk esophageal varices with clinical relevance on liver MDCT is excellent, even by endoscopists, the evaluation of esophageal varices from a recent liver MDCT may be useful to avoid the use of low-yield endoscopy.

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Rate of incidence of hepatocellular carcinoma in patients with compensated viral cirrhosis

Cited by 28 publications

References 0 publications

Hepatitis B virus/hepatitis C virus coinfection: Epidemiology, clinical features, viral interactions and treatment

Hepatitis B virus/hepatitis C virus coinfection: Epidemiology, clinical features, viral interactions and treatment

Undiagnosed cirrhosis occurs frequently in the elderly and requires periodic follow ups and medical treatments

Evaluation of esophageal varices on liver computed tomography: Receiver operating characteristic analyses of the performance of radiologists and endoscopists

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