Rate of Intensive Care Unit admission and outcomes among patients with coronavirus: A systematic review and Meta-analysis

Abstract

Background The rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The objective of the systematic review was to investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus. Methods A comprehensive strategy was conducted in PubMed/Medline; Science direct and LILACS from December 2002 to May 2020 without language restriction. The Heterogeneity among the included studies was checked with forest plot, χ2 test, I2 test, and the p-values. All observational studies reporting rate of ICU admission, the prevalence of mortality and its determinants among ICU admitted patients with coronavirus were included and the rest were excluded Result A total of 646 articles were identified from different databases and 50 articles were selected for evaluation. Thirty-seven Articles with 24983 participants were included. The rate of ICU admission was 32% (95% CI: 26 to 38, 37 studies and 32, 741 participants). The Meta-Analysis revealed that the pooled prevalence of mortality in patients with coronavirus disease in ICU was 39% (95% CI: 34 to 43, 37 studies and 24, 983 participants). Conclusion The Meta-Analysis revealed that approximately one-third of patients admitted to ICU with severe Coronavirus disease and more than thirty percent of patients admitted to ICU with a severe form of COVID-19 for better care died which warns the health care stakeholders to give attention to intensive care patients.

IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection

“…Steroids were used in 58.9% (n = 33) and hydroxychloroquine in 12.5% (n = 7). The median length of hospitalization was 13 [ [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] ] days. Specific characteristics from each patient group (0-10d vs. >10d) are demonstrated in Table 2 .…”

“…Furthermore, the death rate found was 32%, which is higher than other general cohorts [ 20 ]. Nevertheless, given the high ICU admission rate, it is expected that outcomes results become closer to cohorts of critically-ill patients [ 21 ].…”

Red Blood Cell Distribution Is a Significant Predictor of Severe Illness in Coronavirus Disease 2019

“…According to recent data, an unfavorable progression of SARS-CoV-2 infection, such as needing mechanical ventilation and intensive care unit (ICU) admission, occurs in over 30% of patients, and it is then associated with a mortality rate approximating 40% [ 3 ]. Therefore, the identification of demographic, clinical, radiological, and laboratory predictors of unfavorable disease progression must be considered a priority for current clinical and translational research on COVID-19, as this will enable a timely, tailored, and more aggressive treatment for those patients who may have an increased risk of developing severe or critical disease.…”

Prone positioning of non-intubated patients with COVID-19 - A Systematic Review and Meta-analysis

“…0.9% to 32% of these patients require admission to intensive care units (ICU) for advanced respiratory support. [1][2][3][4] A surge in critically ill patients with respiratory failure has overwhelmed ICU capacity in many healthcare systems across the world. Studies published during the early phase of the pandemic have showed poor outcomes in invasively ventilated COVID-19 patients.…”