Rate of non-invasive follicular thyroid neoplasms with papillary-like nuclear features depends on pathologist’s criteria: a multicentre retrospective Southern European study with prolonged follow-up

Fano, Miguel Paja; Zafón, Carles; Iglesias, Carmela; Ugalde, Aitziber; Cameselle-Teijeiro, José; Rodríguez-Carnero, Gemma; Fernández-Seara, Pilar; Anda, Emma; Póvoa, Antónia; Quiceno, Hernán; Sánchez-Gómez, Nancy M.; González, Clarisa; García-Pascual, Luis; Riva, Inés Gómez de la; Blanco, C M Fernández; Meizoso, Telma; Riesco‐Eizaguirre, Garcilaso; Capel, Ismael; Ortega, María Victoria; Mancha, Isabel; Chao, Montserrat; Alcázar, Victoria; Rosello, Esther; Maravall, Javier; López-Agulló, Susana; Pérez-Lázaro, Antonia; Meseguer, Pascual José Claramonte; Sanz, Javier; Paricio, José Joaquín; Echeverria, Saioa; Castaño, Ángel; Bella, María Rosa

doi:10.1007/s12020-021-02610-7

Cited by 15 publications

(11 citation statements)

References 28 publications

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“…In term of demographics, Table 4 and the 3 represented cases (case 1 was an Egyptian male, case 2 was Egyptian female, and case 3 was Qatari female, diagnosed at age of 41, 33, and 52 respectively) shows that our patients' mean age was 41.5 ± 9.91 years, and the condition was more common in females. This is consistent with other studies where mean age was 49.0 ± 12.9 and 49 ± 14.1 years respectively [14] , [16] . As for ethnicity, 60% of our cases were among Qatari and Egyptian patients, and less were among patients of Asian origin (e.g., Filipino, Pakistani, Indian) ( Table 4 ).…”

Section: Discussionsupporting

confidence: 93%

“…As for presentation, 86.6% of our cases were symptomatic ( Table 4 ), in agreement with others where 77.4% were symptomatic [16] . Likewise, 93.3% of our sample were euthyroid ( Table 4 ), concurring with others where 92.8% of cases were euthyroid [17] .…”

Section: Discussionsupporting

confidence: 92%

“…Regarding size, the mean NIFTP size was 2.1 ± 1.75 cm, which concurs with other studies where the mean sizes ranged from 2.18 ± 1.47 cm to 2.5 cm [16] , [17] . For NIFTP reaching 4–5 cm, most surgeons are anxious in treating them conservatively [28] .…”

Section: Discussionsupporting

confidence: 91%

See 2 more Smart Citations

What you see might not be what you get: Analysis of 15 prospective cases of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Hassan

Ansari

Baba

et al. 2022

International Journal of Surgery Case Reports

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

What you see might not be what you get: Analysis of 15 prospective cases of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Hassan

Ansari

Baba

et al. 2022

International Journal of Surgery Case Reports

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“…Other authors have suggested that enhanced detection may contribute to the observed trends, 37 as well as variations in thyroid cancer reporting 38 and classification changes. 39 Further research could help inform our understanding of the observed increase in incidence for this population and help inform interventions for thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

Cancer disparities among non‐Hispanic urban American Indian and Alaska Native populations in the United States, 1999‐2017

Melkonian

Jim

Pete

et al. 2022

Cancer

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BACKGROUND:Disparities in cancer incidence have not been described for urban American Indian/Alaska Native (AI/AN) populations. The purpose of the present study was to examine incidence rates (2008-2017) and trends (1999-2017) for leading cancers in urban non-Hispanic AI/AN (NH AI/AN) compared to non-Hispanic White (NHW) populations living in the same urban areas. METHODS: Incident cases from population-based cancer registries were linked with the Indian Health Service patient registration database for improved racial classification of NH AI/AN populations. This study was limited to counties in Urban Indian Health Organization service areas. Analyses were conducted by geographic region. Age-adjusted rates (per 100,000) and trends (joinpoint regression) were calculated for leading cancers. RESULTS: Rates of colorectal, liver, and kidney cancers were higher overall for urban NH AI/AN compared to urban NHW populations. By region, rates of these cancers were 10% to nearly 4 times higher in NH AI/AN compared to NHW populations. Rates for breast, prostate, and lung cancer were lower in urban NH AI/AN compared to urban NHW populations. Incidence rates for kidney, liver, pancreatic, and breast cancers increased from 2% to nearly 7% annually between 1999 to 2017 in urban NH AI/AN populations. CONCLUSIONS: This study presents cancer incidence rates and trends for the leading cancers among urban NH AI/AN compared to urban NHW populations for the first time, by region, in the United States. Elevated risk of certain cancers among urban NH AI/AN populations and widening cancer disparities highlight important health inequities and missed opportunities for cancer prevention in this population.

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“…Renshaw and Gould explained their motivation to over-diagnose uncertain cases rather than under-diagnose them in North American practice [51]. The gap between North America and the rest of the world became wider, and non-invasive encapsulated follicular variant PTC accounted for nearly 30% of PTC in North American practice [22,39,40,52,53], whereas it was low (1-5%) in most Asian thyroid practices [24,25,[41][42][43][44]48], some European institutes [14,[54][55][56], and a few US centers [25,57]. Hodak et al discussed this overdiagnosis in their excellent commentary, suggesting that for many patients with thyroid cancer, we may often be violating the important dictum primum non nocere (first, do no harm patients) [58].…”

Section: Ras-like Ptcmentioning

confidence: 99%

Different Threshold of Malignancy for RAS-like Thyroid Tumors Causes Significant Differences in Thyroid Nodule Practice

Kakudo

2022

Cancers

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Histopathological diagnosis of papillary thyroid carcinomas (PTCs) is prone to significant observer variation due to different thresholds of RAS-like nuclear changes among pathologists. This gap recently widened due to a defensive attitude by Western pathologists where malpractice litigation is significant. Cases with delicate RAS-like nuclear changes are follicular adenomas when they are noninvasive, follicular carcinomas when invasive, and follicular variant PTCs when they have fully developed PTC-type nuclear features in Asian practice. The different diagnostic threshold of PTC nuclear features resulted in a high (50–90%) incidence of BRAFV600E mutation of PTCs in most Asian countries, whereas it was low (35–50%) in most Western patient cohorts. The contamination of indolent RAS-like tumors in the malignant PTC category in Western patient cohorts explains why the BRAFV600E gene test identifies aggressive PTCs. However, the BRAFV600E test has no prognostic value for Asian PTC patients because most biologically benign or low-risk RAS-like tumors are excluded from PTC. All prognostic analyses of thyroid carcinomas before 2017 must be re-evaluated because most clinical guidelines were established based on data obtained from Western patient cohorts where a significant number of indolent RAS-like tumors were misclassified in the malignant category.

show abstract

Rate of non-invasive follicular thyroid neoplasms with papillary-like nuclear features depends on pathologist’s criteria: a multicentre retrospective Southern European study with prolonged follow-up

Cited by 15 publications

References 28 publications

What you see might not be what you get: Analysis of 15 prospective cases of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

What you see might not be what you get: Analysis of 15 prospective cases of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Cancer disparities among non‐Hispanic urban American Indian and Alaska Native populations in the United States, 1999‐2017

Different Threshold of Malignancy for RAS-like Thyroid Tumors Causes Significant Differences in Thyroid Nodule Practice

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