Rate of preterm birth in pregnant women with vitamin E treatment: a population-based study

Bártfai, Liza; Bártfai, Zoltán; Nedeczky, Iván; Puhó, Erzsébet; Bánhidy, Ferenc; Czeizel, Andr̀ew E.

doi:10.3109/14767058.2011.587060

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…Additionally, in a study in the United States (n = 9968; n = 4992 in the vitamin group and n = 4976 in the placebo group), where at baseline pregnant women were taking 22 IU vitamin E in a daily multivitamin (equal to the RDA), additional vitamin E supplements (400 IU) were not beneficial in reducing the risk of preterm births (102). By contrast, vitamin E supplements were associated with a decreased incidence of preterm births in a Hungarian population study (103). Although it is apparent that the vitamin E status of pregnant women must be adequate to successfully bear a child, these findings suggest that vitamin E supplements in excess of the RDA to adequately nourished women do not provide additional benefits.…”

Section: Consequences Of Low Vitamin E Statusmentioning

confidence: 99%

Vitamin E Inadequacy in Humans: Causes and Consequences

Traber

2014

Advances in Nutrition

220

177

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It is estimated that >90% of Americans do not consume sufficient dietary vitamin E, as α-tocopherol, to meet estimated average requirements. What are the adverse consequences of inadequate dietary α-tocopherol intakes? This review discusses health aspects where inadequate vitamin E status is detrimental and additional vitamin E has reversed the symptoms. In general, plasma α-tocopherol concentrations <12 μmol/L are associated with increased infection, anemia, stunting of growth, and poor outcomes during pregnancy for both the infant and the mother. When low dietary amounts of α-tocopherol are consumed, tissue α-tocopherol needs exceed amounts available, leading to increased damage to target tissues. Seemingly, adequacy of human vitamin E status cannot be assessed from circulating α-tocopherol concentrations, but inadequacy can be determined from “low” values. Circulating α-tocopherol concentrations are very difficult to interpret because, as a person ages, plasma lipid concentrations also increase and these elevations in lipids increase the plasma carriers for α-tocopherol, leading to higher circulating α-tocopherol concentrations. However, abnormal lipoprotein metabolism does not necessarily increase α-tocopherol delivery to tissues. Additional biomarkers of inadequate vitamin E status are needed. Urinary excretion of the vitamin E metabolite α-carboxy-ethyl-hydroxychromanol may fulfill this biomarker role, but it has not been widely studied with regard to vitamin E status in humans or with regard to health benefits. This review evaluated the information available on the adverse consequences of inadequate α-tocopherol status and provides suggestions for avenues for research.

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Section: Consequences Of Low Vitamin E Statusmentioning

confidence: 99%

Vitamin E Inadequacy in Humans: Causes and Consequences

Traber

2014

Advances in Nutrition

220

177

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“…The biological function of vitamin E is an antioxidant that protects tissues and cells from the damaging effect of reactive oxygen species [32]. It may prevent preterm birth by improving the health of the cervix and inhibiting premature cervical remodeling and provide beneficial effect for placenta function [30,33]. …”

Section: Discussionmentioning

confidence: 99%

Maternal Dietary Nutrient Intake and Its Association with Preterm Birth: A Case‐control Study in Beijing, China

et al. 2017

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This study aimed to evaluate dietary nutrient intake among Chinese pregnant women by comparison with Chinese Dietary Reference Intakes (DRIs) and to explore the association between dietary nutrients and preterm birth. A case-control design was conducted in Beijing with 130 preterm delivery mothers in case group and 381 term delivery mothers in control group. Information on mothers’ diet was collected using a food frequency questionnaire, and nutrients and energy intakes were subsequently calculated based on DRIs. Multivariate analysis of variance was used to compare the differences between term and preterm groups in relation to dietary nutrients. Dietary nutrient intakes were imbalanced in both groups compared with Chinese DRIs. Preterm delivery mothers had a lower level of fat and vitamin E intake than term delivery mothers (p < 0.05). Multivariate analysis showed lower vitamin E intake in preterm delivery mothers with a prepregnancy BMI < 18.5 kg/m2 (p < 0.05) and higher carbohydrate intake in preterm delivery mothers with prepregnancy BMI ≥ 24 kg/m2 (p < 0.05). An imbalanced diet in both groups and low level of dietary intakes of fat and vitamin E in preterm group suggest health education measures should be taken to improve the dietary quality of pregnant women, especially for those with an abnormal prepregnancy BMI.

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“…Finally, the most important result of our study is that we have shown that glutathione was able to inhibit all LPS‐induced labor‐associated features in the human myometrium, as well as to prevent inflammation‐induced preterm labor in mice. To date, only a few clinical trials have assessed the effect of antioxidant molecules on pregnancy‐related disorders, and only vitamin E and C have been tested but with disappointing results (61–63). We also tested the effect of vitamin E in our model and found that this vitamin, which does not cross biologic membranes (29), only blocked features related to MCs, while no protective effect was observed on macrophage activation, which may explain the poor clinical effects reported.…”

Section: Discussionmentioning

confidence: 99%

Glutathione prevents preterm parturition and fetal death by targeting macrophage‐induced reactive oxygen species production in the myometrium

et al. 2015

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Preterm birth is an inflammatory process resulting from the massive infiltration of innate immune cells and the production of proinflammatory cytokines in the myometrium. However, proinflammatory cytokines, which induce labor in vivo, fail to induce labor-associated features in human myometrial cells (MCs). We thus aimed to investigate if reactive oxygen species (ROS) production could be the missing step between immune cell activation and MC response. Indeed, we found that ROS production is increased in the human preterm laboring myometrium (27% ROS producing cells, respectively, versus 2% in nonlaboring controls), with 90% ROS production in macrophages. Using LPS-stimulated myometrial samples and cell coculture experiments, we demonstrated that ROS production is required for labor onset. Furthermore, we showed that ROS are required first in the NADPH oxidase (NADPHox)-2/NF-kB-dependent macrophage response to inflammatory stimuli but, more importantly, to trigger macrophage-induced MCs transactivation. Remarkably, in a murine model of LPS-induced preterm labor (inducing delivery within 17 hours, with no pup survival), cotreatment with glutathione delayed labor onset up to 94 hours and prevented in utero fetal distress, allowing 46% pups to survive. These results suggest that targeting ROS production with the macrophage-permeable antioxidant glutathione could constitute a promising strategy to prevent preterm birth.-Hadi, T., Bardou, M., Mace, G., Sicard, P., Wendremaire, M., Barrichon, M., Richaud, S., Demidov, O., Sagot, P., Garrido, C., Lirussi, F. Glutathione prevents preterm parturition and fetal death by targeting macrophage-induced reactive oxygen species production in the myometrium. FASEB J. 29, 2653-2666 (2015). www.fasebj.org

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Rate of preterm birth in pregnant women with vitamin E treatment: a population-based study

Abstract: The study showed nearly 30% reduction in preterm births of pregnant women with vitamin E treatment.

Cited by 11 publications

References 31 publications

Vitamin E Inadequacy in Humans: Causes and Consequences

Vitamin E Inadequacy in Humans: Causes and Consequences

Maternal Dietary Nutrient Intake and Its Association with Preterm Birth: A Case‐control Study in Beijing, China

Glutathione prevents preterm parturition and fetal death by targeting macrophage‐induced reactive oxygen species production in the myometrium

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