Rate of re-infection by Opisthorchis viverrini in an endemic Northeast Thai community after chemotherapy

Upatham, E. S.; Viyanant, Vithoon; Brockelman, Warren Y.; Kurathong, S; Lee, P.; Kraengraeng, R.

doi:10.1016/0020-7519(88)90099-9

Cited by 72 publications

(22 citation statements)

References 17 publications

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“…These findings are in line with the study by Saengsawang et al (2013) who found that the odds of infection of those who had taken praziquantel were 2.31 times higher than those who had never taken the anthelmintic, and with Upatham et al (1988) who showed that about 86% of those treated for OV infection were reinfected within one year. However, the finding is opposite to that reported in the study by Forrer et al (2012), which found that prior treatment with praziquantel was a preventative factor for OV infection.…”

Section: Discussionsupporting

confidence: 82%

Risk factors for Opisthorchis viverrini Infection in Nong Khai Province, Thailand

Chudthaisong

Promthet²,

Bradshaw³

2015

Asian Pacific Journal of Cancer Prevention

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Background: Opisthorchis viverrini (OV) infection is the main risk factor for cholangiocarcinoma and is often found in Northeastern Thailand. The prevalence of OV infection and the incidence of cholangiocarcinoma are major public health problems in this region. Objectives: The objectives of this study were to identify factors associated with OV infection among people in Nong Khai Province in order to develop a prevention programme in the community. Materials and Methods: The data were collected in July 2013. Stool specimens were examined for intestinal parasites within hours after collection using a normal saline wet preparation and the modified KatoKatz technique. A case-control study was conducted to collect information about demographic data, the habit of eating unsafely prepared fish, the safe disposal of waste food, and the practice of defaecating in fields.

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Section: Discussionsupporting

confidence: 82%

Risk factors for Opisthorchis viverrini Infection in Nong Khai Province, Thailand

Chudthaisong

Promthet²,

Bradshaw³

2015

Asian Pacific Journal of Cancer Prevention

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“…The anthelmintic, praziquantel, has been more widely used than any other drug for treatment of OV infection because of its apparent effectiveness and the short time for the healing of damage done by OV following its eradication (Boonmars et al, 2007). However, while praziqantel seems effective against an existing infection with cure rates reported to be as high as 96% and 100% (Soukhathammavong et al, 2011), there is no evidence of any protective immunity against re-infection (Sirisinha et al, 1983;Upatham et al, 1988) and repeated dosing with the anthelmintic is necessary for those re-exposed to infection.…”

Section: Infection With Opisthorchis Viverrini and Use Of Praziquantementioning

confidence: 99%

Infection with Opisthorchis viverrini and Use of Praziquantel among a Working-age Population in Northeast Thailand

Saengsawang

Promthet²,

Bradshaw³

2013

Asian Pacific Journal of Cancer Prevention

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Infection with Opisthorchis viverrini (OV) due to eating certain traditional freshwater fish dishes is the principal risk factor for cholangiocarcinoma in Northeast Thailand where the infection is endemic and the incidence of this form of primary liver cancer has been the highest in the world. This paper is the second report of a prospective research project to monitor the impacts of a national liver fluke control programme in a rural community of Northeast Thailand. A sample of 684 villagers aged 20-65 years completed an interview questionnaire and were tested for infection using the Kato thick smear technique. The questionnaire was designed for the exploration of associations between OV infection, previous treatment with praziquantel, and knowledge and beliefs about the drug. The data were analysed using descriptive statistics and multiple logistic regression. The overall prevalence of OV infection was 37.2% and was highest in the 20-35 year age group, in those with a university degree and in those employed in the government sector. As many as 91.8% reported eating fish dishes known to place them at risk of infection. In the multiple regression analysis, previous use of praziquantel and lack of knowledge about whether or not the drug has a protective effect against re-infection were the only factors related to OV infection (OR adj = 2.31, 95%CI =1.40-3.79 and OR adj = 1.95, 95%CI= 1.24-3.05). The findings were discussed in terms of the possibly unwise dependency on praziquantel as a primary element in a control programme.

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“…24 Reinfections, however, are a common phenomenon in many endemic areas. 25,26 An integrated prevention and control program based on health education plus sanitary improvement has been recommended in the past, 3 and more recently, it was recommended in the work by Sithithaworn and others 27,28 that targeted school children. One means for potentially reducing infection rates is control of the intermediate hosts.…”

Section: Resultsmentioning

confidence: 99%

Exceptionally High Prevalence of Infection of Bithynia siamensis goniomphalos with Opisthorchis viverrini Cercariae in Different Wetlands in Thailand and Lao PDR

Kiatsopit

Sithithaworn²,

Saijuntha³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. The carcinogenic liver fluke, Opisthorchis viverrini, requires Bithynia snail intermediate hosts in its life cycle. However, the prevalence of O. viverrini in snail intermediate hosts is typically low ( 1%). Here, we examined B. siamensis goniomphalos from 48 localities in Thailand and The Lao People's Democratic Republic (Lao PDR) and reported highprevalence levels of O. viverrini. The highest-prevalence levels per locality were 6.93% (mean = 3.04%) in Thailand and 8.37% (mean = 2.01%) in Lao PDR; 4 of 13 localities examined showed prevalence higher than any prevalence previously recorded. The number of cercariae infecting snails and their prevalence were positively correlated with the size of the snails. High prevalence occurred in the Songkram River wetland (Thailand) and the Nam Ngum River wetland (Lao PDR). Our results show that transmission of O. viverrini from humans as well as animal reservoir hosts to snail intermediate hosts is ongoing and potentially increasing in endemic areas across Thailand and Lao PDR.

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Rate of re-infection by Opisthorchis viverrini in an endemic Northeast Thai community after chemotherapy

Cited by 72 publications

References 17 publications

Risk factors for Opisthorchis viverrini Infection in Nong Khai Province, Thailand

Risk factors for Opisthorchis viverrini Infection in Nong Khai Province, Thailand

Infection with Opisthorchis viverrini and Use of Praziquantel among a Working-age Population in Northeast Thailand

Exceptionally High Prevalence of Infection of Bithynia siamensis goniomphalos with Opisthorchis viverrini Cercariae in Different Wetlands in Thailand and Lao PDR

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