Rate of sentinel lymph node identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital, Thailand

Abstract

Background:The sentinel lymph node (SLN) is the first lymph node to receive lymphatic drainage from a primary breast tumor. If the SLN contains no metastatic tumor, then it is unlikely other lymph nodes will contain breast cancer metastasis. When the SLN does contains metastasis, an axillary lymph node dissection (ALND) is recommended to further stage the axilla and to maintain locoregional control. SLNs can be identified by using a dye, radioisotope, or combined techniques. Objective: To determine the rate of SLN identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital, Thailand, and factors that affect it. Methods: This prospective study of 106 consecutive cases breast cancer enrolled 105 women (1 bilateral breast cancer case) between October 2011 and October 2013 at Charoenkrung Pracharak Hospital. Clinical and pathological features were analyzed for the effectiveness of SLN identification using isosulfan blue dye. Results: The rate of SLN identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital was 92%. The method was safe and well tolerated in early-stage breast cancer patients. Conclusion:The effectiveness of sentinel node identification using isosulfan blue dye in breast cancer patients at Charoenkrung Pracharak Hospital is consistent with that shown in studies from other countries.

Outcome of Sentinel Lymph Node Biopsy with Methylene Blue Dye in Early-stage Breast Cancer

“…A study was conducted in India by Asthurkar AV., [30] showed there was no relation between age and Tumor size. Georgette S. W., et al, [31] the greater the T stage, the higher the incidence of Level I and level II involvement (4.4% in T1 and 36.35% in T2) which is just similar to our study. In the maximum study there were no relation in between Tumor site, location and sentinel lymph node biopsy procedure.…”

“…The ACOSOG Z0011 study showed no difference in local or regional recurrence between patients with single positive sentinel lymph nodes who were randomized or either SLNB only or SLNB and ALND. Alberitini et al, [31] showed combined dye directed and probe directed mapping in 62 patients with primary early breast carcinoma, the detection rate was higher (92%) in combined group than dye (73%) only group. The current study showed in ALND sub group, wound infection rate was 5.5% and the seroma formation in axilla was only in 3 cases (16.7%) and paresthesia in arm found in 11.1% of cases.…”

Comparative Study on Intraoperative Localization of Sentinel Lymph Node in Breast Cancer Patients using Tc 99m Sulfur Colloid and Blue Dye

“…Reasons for failure of sentinel lymph node localization may be prior excision of the breast tumor or prior axillary node surgery or faulty techniques etc. [18]. In our study, we were not able to exactly identify the cause, but one of the reasons could be that not all the patients were administered with radiocolloid by same nuclear medicine physician which can be lead to varying results due to varying techniques.…”